Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972372292> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W1972372292 abstract "Indoleamine 2,3-dioxygenase-1 (IDO1) mediates oxidative cleavage of tryptophan, an amino acid essential for cell proliferation and survival. The depletion of tryptophan and the generation of tryptophan metabolites have been demonstrated to be an important regulator of immune function. IDO1 is induced by interferons and TLR agonists and is expressed in a wide variety of human cancers as well as in the tumor-draining lymph nodes. High IDO1 expression is significantly associated with more rapid disease progression and poor prognosis in multiple cancer types. Numerous studies have shown that IDO1 negatively regulates immune functions via several potential cellular mechanisms, which in turn allows tumor escape from host immune surveillance. Therefore, inhibition of IDO1 may have therapeutic potential in cancer and IDO1 expression may serve as a selective marker of a responsive population. INCB024360, a novel IDO1-selective inhibitor, is currently being evaluated in clinical trials of cancer patients. To support the clinical development of INCB024360, we have developed and validated an immunohistochemistry (IHC)-based method using rabbit polyclonal antisera that specifically detects IDO1 protein expression. The method has been used to determine IDO1 expression in primary biopsies from patients studied in INCB024360 clinical trials. The method can be used to determine the prevalence of IDO1 expression in a variety of human cancers, identify histologic subtypes that might be associated with IDO1 expression and examine IDO1 coexpression with other immune modifying pathways.Citation Information: Mol Cancer Ther 2013;12(11 Suppl):C42.Citation Format: Xiangdong Liu, Gengjie Yang, Alexander Margulis, Rich Wynn, Peggy Scherle, Robert Newton. Development and validation of an IHC-based detection method for studying indoleamine 2,3-dioxygenase 1 (IDO1) expression in human cancers. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2013 Oct 19-23; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2013;12(11 Suppl):Abstract nr C42." @default.
- W1972372292 created "2016-06-24" @default.
- W1972372292 creator A5003951879 @default.
- W1972372292 creator A5018193992 @default.
- W1972372292 creator A5018886805 @default.
- W1972372292 creator A5068506060 @default.
- W1972372292 creator A5072723850 @default.
- W1972372292 creator A5086931916 @default.
- W1972372292 date "2013-11-01" @default.
- W1972372292 modified "2023-09-25" @default.
- W1972372292 title "Abstract C42: Development and validation of an IHC-based detection method for studying indoleamine 2,3-dioxygenase 1 (IDO1) expression in human cancers." @default.
- W1972372292 doi "https://doi.org/10.1158/1535-7163.targ-13-c42" @default.
- W1972372292 hasPublicationYear "2013" @default.
- W1972372292 type Work @default.
- W1972372292 sameAs 1972372292 @default.
- W1972372292 citedByCount "0" @default.
- W1972372292 crossrefType "proceedings-article" @default.
- W1972372292 hasAuthorship W1972372292A5003951879 @default.
- W1972372292 hasAuthorship W1972372292A5018193992 @default.
- W1972372292 hasAuthorship W1972372292A5018886805 @default.
- W1972372292 hasAuthorship W1972372292A5068506060 @default.
- W1972372292 hasAuthorship W1972372292A5072723850 @default.
- W1972372292 hasAuthorship W1972372292A5086931916 @default.
- W1972372292 hasConcept C121608353 @default.
- W1972372292 hasConcept C126322002 @default.
- W1972372292 hasConcept C203014093 @default.
- W1972372292 hasConcept C204232928 @default.
- W1972372292 hasConcept C2776706248 @default.
- W1972372292 hasConcept C502942594 @default.
- W1972372292 hasConcept C515207424 @default.
- W1972372292 hasConcept C55493867 @default.
- W1972372292 hasConcept C71924100 @default.
- W1972372292 hasConcept C83478079 @default.
- W1972372292 hasConcept C86803240 @default.
- W1972372292 hasConcept C8891405 @default.
- W1972372292 hasConceptScore W1972372292C121608353 @default.
- W1972372292 hasConceptScore W1972372292C126322002 @default.
- W1972372292 hasConceptScore W1972372292C203014093 @default.
- W1972372292 hasConceptScore W1972372292C204232928 @default.
- W1972372292 hasConceptScore W1972372292C2776706248 @default.
- W1972372292 hasConceptScore W1972372292C502942594 @default.
- W1972372292 hasConceptScore W1972372292C515207424 @default.
- W1972372292 hasConceptScore W1972372292C55493867 @default.
- W1972372292 hasConceptScore W1972372292C71924100 @default.
- W1972372292 hasConceptScore W1972372292C83478079 @default.
- W1972372292 hasConceptScore W1972372292C86803240 @default.
- W1972372292 hasConceptScore W1972372292C8891405 @default.
- W1972372292 hasLocation W19723722921 @default.
- W1972372292 hasOpenAccess W1972372292 @default.
- W1972372292 hasPrimaryLocation W19723722921 @default.
- W1972372292 hasRelatedWork W2194115454 @default.
- W1972372292 hasRelatedWork W2218426117 @default.
- W1972372292 hasRelatedWork W2338984480 @default.
- W1972372292 hasRelatedWork W2475502170 @default.
- W1972372292 hasRelatedWork W2587947559 @default.
- W1972372292 hasRelatedWork W2739812295 @default.
- W1972372292 hasRelatedWork W2886227039 @default.
- W1972372292 hasRelatedWork W2886901452 @default.
- W1972372292 hasRelatedWork W2893814357 @default.
- W1972372292 hasRelatedWork W2911584347 @default.
- W1972372292 hasRelatedWork W2980333317 @default.
- W1972372292 hasRelatedWork W3014990254 @default.
- W1972372292 hasRelatedWork W3022795538 @default.
- W1972372292 hasRelatedWork W3096231745 @default.
- W1972372292 hasRelatedWork W3160431196 @default.
- W1972372292 hasRelatedWork W3164178299 @default.
- W1972372292 hasRelatedWork W3174249227 @default.
- W1972372292 hasRelatedWork W3184022759 @default.
- W1972372292 hasRelatedWork W3198002070 @default.
- W1972372292 hasRelatedWork W3199257705 @default.
- W1972372292 isParatext "false" @default.
- W1972372292 isRetracted "false" @default.
- W1972372292 magId "1972372292" @default.
- W1972372292 workType "article" @default.