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- W1972372336 abstract "Six different monoclonal antibodies (MAbs) to human chorionic gonadotropin (hCG) were evaluated for radioimmunodetection in Golden Syrian Hamsters bearing a human choriocarcinoma in the cheek pouch (188-516 mIU of hCG/g). The affinity of three antibodies when determined were high and five of the antibodies were of IgG1 subclass. After i.v. injection of Staphylococcus Protein A (SPA) affinity purified radioiodinated antibodies, tissue distribution studies demonstrated that antibody 061 had higher target-to-nontarget ratios than the other five antibodies. The mean tumor:muscle ratio of 131I-MAb 061 was 27.5 in four animals, where the mean tumor:muscle ratio of four animals injected with 131I-labeled control monoclonal IgG1 Kappa from MOPC-21 murine myeloma (MOPC-21) was only 2.2. Sharp images of the cheek pouch tumor were obtained at five days following a tracer dose of 131I-061 MAb, but not with the same dose of a 131I-MOPC-21." @default.
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- W1972372336 date "1984-01-01" @default.
- W1972372336 modified "2023-09-25" @default.
- W1972372336 title "Selection of Monoclonal Antibody to hCG which Localizes in Human Choriocarcinoma Growing in the Syrian Hamster Cheek Pouch" @default.
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- W1972372336 doi "https://doi.org/10.1089/hyb.1984.3.41" @default.
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