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- W1972372574 abstract "beta-Catenin, which is frequently overexpressed in a variety of human cancers including esophageal cancer, mediates cancer cell proliferation and tumor growth. In the present study, we used a human U6 promoter-driven DNA-template approach to induce short hairpin RNA (shRNA)-triggered RNA interference to silence beta-catenin gene expression in human esophageal squamous cell carcinoma cell line Eca-109, and then evaluated its effects on the proliferation and growth of tumor cells in vitro and in nude mice. beta-Catenin expression levels decreased markedly in Eca-109 cells transfected with a plasmid expressing shRNA for beta-catenin. Downregulation of beta-catenin was concomitantly accompanied by reduction of cyclin D1, colony formation, and growth inhibition of Eca-109 cells in vitro. The mechanism appears to be the G0/G1 phase arrest but not induction of apoptosis. In vivo, treatment of Eca-109 cells with beta-catenin shRNA greatly impeded tumor growth in nude mice. We conclude that plasmid vector-mediated beta-catenin RNA interference holds great promise as a novel treatment on human esophageal cancer with beta-catenin overexpression." @default.
- W1972372574 created "2016-06-24" @default.
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- W1972372574 date "2009-04-01" @default.
- W1972372574 modified "2023-09-27" @default.
- W1972372574 title "Gene silencing of ß-catenin by RNAi inhibits cell proliferation in human esophageal cancer cells<i>in vitro</i>and in nude mice" @default.
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- W1972372574 doi "https://doi.org/10.1111/j.1442-2050.2008.00875.x" @default.
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