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• W1972373816 abstract "Genetic evidence suggests that inhibition of amyloid fibril formation by small molecules should be effective against amyloid diseases. Known amyloid inhibitors appear to function by shifting the aggregation equilibrium away from the amyloid state. Here, we describe a series of transthyretin amyloidosis inhibitors that functioned by increasing the kinetic barrier associated with misfolding, preventing amyloidogenesis by stabilizing the native state. The trans-suppressor mutation, threonine 119 --> methionine 119, which is known to ameliorate familial amyloid disease, also functioned through kinetic stabilization, implying that this small-molecule strategy should be effective in treating amyloid diseases." @default.
• W1972373816 created "2016-06-24" @default.
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• W1972373816 date "2003-01-31" @default.
• W1972373816 modified "2023-10-11" @default.
• W1972373816 title "Prevention of Transthyretin Amyloid Disease by Changing Protein Misfolding Energetics" @default.
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• W1972373816 doi "https://doi.org/10.1126/science.1079589" @default.
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