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- W1972376799 abstract "The syntheses of 6-ethyl 2c, 6-n-propyl 2d, 6-n-hexyl 2c, 6-phenethyl 2f, 6-neopentyl 2g and 7-neopentyl 2h 5,6,7,8-tetrahydropterins are described. The oxidation of these gave the corresponding quinonoid species 3c—3h all of which were good substrates for dihydropteridine reductase from human brain when compared with the natural cofactor quinonoid dihydrobiopterin 3i, the quinonoid 6- and 7-methyl dihydropterins 3a and 3b, and quinonoid dihydrofolic acid 3j. In contrast, 5-2′-propylimino and 5-2′-octylimino 2,4-diaminopyrimidin-6 (1H)-ones 7a and 7b were devoid of substrate or inhibitor activities. The potential use of these lipophilic pterins in the therapy of diseases where there is a deficiency of tetrahydrobiopterin is discussed.Ce travail décrit les synthèses des éthyl-6 2c, n-propyl-6 2d, n-hexyl-6 2e, phénéthyl-6 2f, néopentyl-6 2g et néopentyl-7 2h tétrahydro-5,6,7,8 ptérines. L'oxydation de ces ptérines donne les analogues quinonoïdiques 3c—3h qui sont de bons substrats de la dihydroptéridine réductase, d'origine humaine, comparés au cofacteur naturel quinonoïdique dihydrobioptérine 3i, aux méthyl-6 (et-7)dihydroptéridines quinonoïdiques 3a et 3b, et la forme quinonoïdique de l'acide dihydrofolique 3j. Au contraire les propylimino-5-2′ et octylimino-5-2′ diamino-2,4 pyrimidin(1H-ones-6 7a et 7b ne conviennent pas comme substrat et n'inhibent pas cet enzyme. On discute la possibilité d'utiliser ces ptérines lipophiles dans les cas de carence de tétrahydrobioptérine." @default.
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- W1972376799 date "1990-01-01" @default.
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- W1972376799 title "Protection of cultured lens epithelial cells from H2O2 insult by sod mimics" @default.
- W1972376799 doi "https://doi.org/10.1016/0891-5849(90)90240-j" @default.
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