Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972380512> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W1972380512 abstract "It has been reported that vasodilatory prostaglandins have cytoprotective effects against various types of liver damage. We investigated the effects OP 2507, a stable analogue of prostaglandin I2, on carbon tetrachloride-induced liver damage in starved rats. Intraperitoneal administration of OP 2507 at 1,500 micrograms/kg lessened both an increase in serum alanine aminotransferase activity and an inhibition of starvation ketosis, both of which were induced by carbon tetrachloride. At lower doses, however, OP 2507 not only failed to ameliorate the carbon tetrachloride-induced changes, but it actually exaggerated them. Although the deterioration of carbon tetrachloride-induced liver damage by lower doses of OP 2507 was not statistically significant, it seems possible that OP 2507 has dual effects on carbon tetrachloride-induced liver damage. While none of the three agents cimetidine, reduced glutathione and deferoxamine, prevented increase in serum alanine aminotransferase activity induced with lower dose OP 2507, allopurinol had a tendency to prevent the increase, indicating that lower doses of OP 2507 may promote a reaction catalyzed by xanthine oxidase. We propose that both the co-administration of prostaglandins and other potentially hepatotoxic drugs, and the administration of prostaglandins to patients with drug-induced liver damage should be done carefully." @default.
- W1972380512 created "2016-06-24" @default.
- W1972380512 creator A5003588013 @default.
- W1972380512 creator A5016075655 @default.
- W1972380512 creator A5032712912 @default.
- W1972380512 creator A5071656611 @default.
- W1972380512 creator A5074022310 @default.
- W1972380512 creator A5082846066 @default.
- W1972380512 date "1996-01-01" @default.
- W1972380512 modified "2023-09-26" @default.
- W1972380512 title "Effects of OP 2507, a Stable Analogue of Prostaglandin I2, on Carbon Tetrachloride-Induced Liver Damage in Starved Rats." @default.
- W1972380512 cites W1572362848 @default.
- W1972380512 cites W1965938315 @default.
- W1972380512 cites W1966048978 @default.
- W1972380512 cites W1968521617 @default.
- W1972380512 cites W1992716884 @default.
- W1972380512 cites W2010728008 @default.
- W1972380512 cites W2037893952 @default.
- W1972380512 cites W2049183888 @default.
- W1972380512 cites W2049285581 @default.
- W1972380512 cites W2052919943 @default.
- W1972380512 cites W2398516278 @default.
- W1972380512 cites W2419225991 @default.
- W1972380512 cites W2424342172 @default.
- W1972380512 doi "https://doi.org/10.1620/tjem.178.279" @default.
- W1972380512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8727710" @default.
- W1972380512 hasPublicationYear "1996" @default.
- W1972380512 type Work @default.
- W1972380512 sameAs 1972380512 @default.
- W1972380512 citedByCount "2" @default.
- W1972380512 crossrefType "journal-article" @default.
- W1972380512 hasAuthorship W1972380512A5003588013 @default.
- W1972380512 hasAuthorship W1972380512A5016075655 @default.
- W1972380512 hasAuthorship W1972380512A5032712912 @default.
- W1972380512 hasAuthorship W1972380512A5071656611 @default.
- W1972380512 hasAuthorship W1972380512A5074022310 @default.
- W1972380512 hasAuthorship W1972380512A5082846066 @default.
- W1972380512 hasBestOaLocation W19723805121 @default.
- W1972380512 hasConcept C126322002 @default.
- W1972380512 hasConcept C134018914 @default.
- W1972380512 hasConcept C178790620 @default.
- W1972380512 hasConcept C185592680 @default.
- W1972380512 hasConcept C2777359374 @default.
- W1972380512 hasConcept C2780261098 @default.
- W1972380512 hasConcept C2780664492 @default.
- W1972380512 hasConcept C71924100 @default.
- W1972380512 hasConcept C98274493 @default.
- W1972380512 hasConceptScore W1972380512C126322002 @default.
- W1972380512 hasConceptScore W1972380512C134018914 @default.
- W1972380512 hasConceptScore W1972380512C178790620 @default.
- W1972380512 hasConceptScore W1972380512C185592680 @default.
- W1972380512 hasConceptScore W1972380512C2777359374 @default.
- W1972380512 hasConceptScore W1972380512C2780261098 @default.
- W1972380512 hasConceptScore W1972380512C2780664492 @default.
- W1972380512 hasConceptScore W1972380512C71924100 @default.
- W1972380512 hasConceptScore W1972380512C98274493 @default.
- W1972380512 hasLocation W19723805121 @default.
- W1972380512 hasLocation W19723805122 @default.
- W1972380512 hasOpenAccess W1972380512 @default.
- W1972380512 hasPrimaryLocation W19723805121 @default.
- W1972380512 hasRelatedWork W1987081056 @default.
- W1972380512 hasRelatedWork W1988343102 @default.
- W1972380512 hasRelatedWork W2002498542 @default.
- W1972380512 hasRelatedWork W2016034363 @default.
- W1972380512 hasRelatedWork W2025421388 @default.
- W1972380512 hasRelatedWork W2042132178 @default.
- W1972380512 hasRelatedWork W2054950830 @default.
- W1972380512 hasRelatedWork W2437916108 @default.
- W1972380512 hasRelatedWork W2899084033 @default.
- W1972380512 hasRelatedWork W77065326 @default.
- W1972380512 isParatext "false" @default.
- W1972380512 isRetracted "false" @default.
- W1972380512 magId "1972380512" @default.
- W1972380512 workType "article" @default.