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• W1972384657 endingPage "116" @default.
• W1972384657 startingPage "104" @default.
• W1972384657 abstract "A recent focus of addiction research has been on the effect of drug exposure on the neural processes that mediate the acquisition and performance of goal-directed instrumental actions. Deficits in goal-directed control and a consequent dysregulation of habit learning processes have been described as resulting in compulsive drug seeking. Similarly, considerable research has focussed on the motivational and emotional changes that drugs produce and that result in changes in the incentive processes that modulate goal-directed performance. Although these areas have developed independently, we argue that the effects they described are likely not independent. Here we hypothesize that these changes result from a core deficit in the way the learning and performance factors that support goal-directed action are integrated at a neural level to maintain behavioural control. A dorsal basal ganglia stream mediating goal-directed learning and a ventral stream mediating various performance factors find several points of integration in the cortical basal ganglia system, most notably in the thalamocortical network linking basal ganglia output to a variety of cortical control centres. Recent research in humans and other animals is reviewed suggesting that learning and performance factors are integrated in a network centred on the mediodorsal thalamus and that disintegration in this network may provide the basis for a ‘switch’ from recreational to dysregulated drug seeking resulting in the well documented changes associated with addiction. This article is part of a Special Issue entitled SI:Addiction circuits." @default.
• W1972384657 created "2016-06-24" @default.
• W1972384657 creator A5071349221 @default.
• W1972384657 creator A5081430078 @default.
• W1972384657 creator A5087840723 @default.
• W1972384657 date "2015-12-01" @default.
• W1972384657 modified "2023-10-18" @default.
• W1972384657 title "Thalamocortical integration of instrumental learning and performance and their disintegration in addiction" @default.
• W1972384657 cites W1522746369 @default.
• W1972384657 cites W1601908226 @default.
• W1972384657 cites W1694031258 @default.
• W1972384657 cites W1903440721 @default.
• W1972384657 cites W1967123776 @default.
• W1972384657 cites W1968365796 @default.
• W1972384657 cites W1971014321 @default.
• W1972384657 cites W1971037745 @default.
• W1972384657 cites W1975401347 @default.
• W1972384657 cites W1975617742 @default.
• W1972384657 cites W1976208812 @default.
• W1972384657 cites W1978122571 @default.
• W1972384657 cites W1978686840 @default.
• W1972384657 cites W1978906168 @default.
• W1972384657 cites W1980505353 @default.
• W1972384657 cites W1982150127 @default.
• W1972384657 cites W1983183519 @default.
• W1972384657 cites W1990042350 @default.
• W1972384657 cites W1994488136 @default.
• W1972384657 cites W1997413052 @default.
• W1972384657 cites W1998501022 @default.
• W1972384657 cites W2000214310 @default.
• W1972384657 cites W2001301867 @default.
• W1972384657 cites W2002169578 @default.
• W1972384657 cites W2003412240 @default.
• W1972384657 cites W2005962945 @default.
• W1972384657 cites W2008145253 @default.
• W1972384657 cites W2010040903 @default.
• W1972384657 cites W2010156528 @default.
• W1972384657 cites W2010382717 @default.
• W1972384657 cites W2011629807 @default.
• W1972384657 cites W2018885421 @default.
• W1972384657 cites W2020415214 @default.
• W1972384657 cites W2022045734 @default.
• W1972384657 cites W2023732657 @default.
• W1972384657 cites W2024365408 @default.
• W1972384657 cites W2025466447 @default.
• W1972384657 cites W2026522685 @default.
• W1972384657 cites W2029874896 @default.
• W1972384657 cites W2034389479 @default.
• W1972384657 cites W2037304999 @default.
• W1972384657 cites W2038241672 @default.
• W1972384657 cites W2040774694 @default.
• W1972384657 cites W2040903782 @default.
• W1972384657 cites W2041027326 @default.
• W1972384657 cites W2041457323 @default.
• W1972384657 cites W2047831967 @default.
• W1972384657 cites W2048546928 @default.
• W1972384657 cites W2048661364 @default.
• W1972384657 cites W2049375392 @default.
• W1972384657 cites W2054749214 @default.
• W1972384657 cites W2055404231 @default.
• W1972384657 cites W2055523610 @default.
• W1972384657 cites W2055608364 @default.
• W1972384657 cites W2057001461 @default.
• W1972384657 cites W2058318822 @default.
• W1972384657 cites W2058362897 @default.
• W1972384657 cites W2058623567 @default.
• W1972384657 cites W2061863046 @default.
• W1972384657 cites W2063384087 @default.
• W1972384657 cites W2066848874 @default.
• W1972384657 cites W2067690062 @default.
• W1972384657 cites W2069640850 @default.
• W1972384657 cites W2071154532 @default.
• W1972384657 cites W2072371006 @default.
• W1972384657 cites W2073346596 @default.
• W1972384657 cites W2076432816 @default.
• W1972384657 cites W2078045231 @default.
• W1972384657 cites W2082648681 @default.
• W1972384657 cites W2084035844 @default.
• W1972384657 cites W2084351912 @default.
• W1972384657 cites W2085553767 @default.
• W1972384657 cites W2086146798 @default.
• W1972384657 cites W2086615576 @default.
• W1972384657 cites W2088135927 @default.
• W1972384657 cites W2090931660 @default.
• W1972384657 cites W2092659452 @default.
• W1972384657 cites W2094933282 @default.
• W1972384657 cites W2096050184 @default.
• W1972384657 cites W2098342476 @default.
• W1972384657 cites W2102726432 @default.
• W1972384657 cites W2102914547 @default.
• W1972384657 cites W2107755617 @default.
• W1972384657 cites W2112337921 @default.
• W1972384657 cites W2113679854 @default.
• W1972384657 cites W2115998792 @default.
• W1972384657 cites W2116283675 @default.
• W1972384657 cites W2117137709 @default.
• W1972384657 cites W2118830830 @default.
• W1972384657 cites W2119102767 @default.

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