FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972387355> ?p ?o ?g. }

• W1972387355 endingPage "683" @default.
• W1972387355 startingPage "677" @default.
• W1972387355 abstract "Cys=: cysteine; GABA=: γ-aminobutyric acid; GlyR=: glycine receptor; KCC2=: K+, Cl− cotransporter 2; NKH=: nonketotic hyperglycinemia; NMDAR=: NMDA receptor; VGAT=: vesicular GABA transporter; VIAAT=: vesicular inhibitory amino acid transporter.Glycine is a major neurotransmitter of inhibitory neurons in the spinal cord and brainstem. In many of these neurons, glycine coexists with γ-aminobutyric acid (GABA). The synaptic availability of glycine is controlled by 2 different transporters, and its postsynaptic effects are mediated by a specific chloride (Cl−) channel receptor. In the adult nervous system, glycine exerts fast postsynaptic inhibition that is important for control of excitability of motor neurons, auditory processing, pain transmission in the dorsal horn, and other functions. Corelease of GABA may affect the temporal profile of the postsynaptic effects of glycine. Glycine is also a coagonist of glutamate on NMDA receptors (NMDARs). Studies in vitro and in knockout mouse models have provided insight on the complex synaptic interactions among glycine, GABA, and glutamate, and on the consequences of impaired regulation of glycinergic transmission in the nervous system. Excessive synaptic levels of glycine may explain the manifestations of nonketotic hyperglycinemia, whereas loss-of-function mutations impairing glycinergic signaling have been linked to familial hyperekplexia. Autoimmune disorders affecting the glycine receptor (GlyR) complex may also result in excessive motoneuron excitability. Pharmacologic blockade of a glycine transporter may constitute a novel approach to increase NMDAR activity in schizophrenia. Many of these topics have been recently reviewed.1,–,9### Synthesis and storage.Glycine is the primary neurotransmitter of many inhibitory interneurons in the spinal cord and brainstem, including the ventral horn and motor cranial nerve nuclei, dorsal horn and trigeminal nuclei, and auditory and vestibular systems; it also mediates inhibitory effects of some amacrine cells and Golgi cells of the cerebellum.1 Glycine also has an essential role in intermediate metabolism; for example, it is the precursor to the one-carbon pool of folic acid intermediates that are fundamental to many synthetic reactions. Glycine is catabolized via the glycine cleavage system, a group …" @default.
• W1972387355 created "2016-06-24" @default.
• W1972387355 creator A5069111019 @default.
• W1972387355 date "2011-08-15" @default.
• W1972387355 modified "2023-10-16" @default.
• W1972387355 title "Glycine and its synaptic interactions: Functional and clinical implications" @default.
• W1972387355 cites W1580316067 @default.
• W1972387355 cites W1580630655 @default.
• W1972387355 cites W1597054100 @default.
• W1972387355 cites W1788084167 @default.
• W1972387355 cites W1862870409 @default.
• W1972387355 cites W1866618643 @default.
• W1972387355 cites W1978023994 @default.
• W1972387355 cites W1978269241 @default.
• W1972387355 cites W1981111905 @default.
• W1972387355 cites W1983636710 @default.
• W1972387355 cites W1987514282 @default.
• W1972387355 cites W1989524951 @default.
• W1972387355 cites W201532556 @default.
• W1972387355 cites W2019130280 @default.
• W1972387355 cites W2024217354 @default.
• W1972387355 cites W2025066952 @default.
• W1972387355 cites W2026455366 @default.
• W1972387355 cites W2026594181 @default.
• W1972387355 cites W2033843602 @default.
• W1972387355 cites W2035792622 @default.
• W1972387355 cites W2037458202 @default.
• W1972387355 cites W2038750337 @default.
• W1972387355 cites W2047137871 @default.
• W1972387355 cites W2049702005 @default.
• W1972387355 cites W2049879893 @default.
• W1972387355 cites W2049978992 @default.
• W1972387355 cites W2054650420 @default.
• W1972387355 cites W2063856776 @default.
• W1972387355 cites W2064194615 @default.
• W1972387355 cites W2065371727 @default.
• W1972387355 cites W2066835162 @default.
• W1972387355 cites W2072179794 @default.
• W1972387355 cites W2072465203 @default.
• W1972387355 cites W2074634273 @default.
• W1972387355 cites W2078563366 @default.
• W1972387355 cites W2081678712 @default.
• W1972387355 cites W2084414231 @default.
• W1972387355 cites W2089244845 @default.
• W1972387355 cites W2094772612 @default.
• W1972387355 cites W2099450092 @default.
• W1972387355 cites W2101630258 @default.
• W1972387355 cites W2108265031 @default.
• W1972387355 cites W2110655603 @default.
• W1972387355 cites W2117445820 @default.
• W1972387355 cites W2123804450 @default.
• W1972387355 cites W2125269329 @default.
• W1972387355 cites W2134765462 @default.
• W1972387355 cites W2138830401 @default.
• W1972387355 cites W2148467321 @default.
• W1972387355 cites W2151758903 @default.
• W1972387355 cites W2151875814 @default.
• W1972387355 cites W2156405486 @default.
• W1972387355 cites W2158404383 @default.
• W1972387355 cites W2167840964 @default.
• W1972387355 cites W2170099066 @default.
• W1972387355 cites W24437571 @default.
• W1972387355 doi "https://doi.org/10.1212/wnl.0b013e31822a2791" @default.
• W1972387355 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21844524" @default.
• W1972387355 hasPublicationYear "2011" @default.
• W1972387355 type Work @default.
• W1972387355 sameAs 1972387355 @default.
• W1972387355 citedByCount "12" @default.
• W1972387355 countsByYear W19723873552012 @default.
• W1972387355 countsByYear W19723873552015 @default.
• W1972387355 countsByYear W19723873552017 @default.
• W1972387355 countsByYear W19723873552018 @default.
• W1972387355 countsByYear W19723873552019 @default.
• W1972387355 countsByYear W19723873552021 @default.
• W1972387355 countsByYear W19723873552022 @default.
• W1972387355 countsByYear W19723873552023 @default.
• W1972387355 crossrefType "journal-article" @default.
• W1972387355 hasAuthorship W1972387355A5069111019 @default.
• W1972387355 hasConcept C15744967 @default.
• W1972387355 hasConcept C169760540 @default.
• W1972387355 hasConcept C185592680 @default.
• W1972387355 hasConcept C2777756961 @default.
• W1972387355 hasConcept C515207424 @default.
• W1972387355 hasConcept C55493867 @default.
• W1972387355 hasConceptScore W1972387355C15744967 @default.
• W1972387355 hasConceptScore W1972387355C169760540 @default.
• W1972387355 hasConceptScore W1972387355C185592680 @default.
• W1972387355 hasConceptScore W1972387355C2777756961 @default.
• W1972387355 hasConceptScore W1972387355C515207424 @default.
• W1972387355 hasConceptScore W1972387355C55493867 @default.
• W1972387355 hasIssue "7" @default.
• W1972387355 hasLocation W19723873551 @default.
• W1972387355 hasLocation W19723873552 @default.
• W1972387355 hasOpenAccess W1972387355 @default.
• W1972387355 hasPrimaryLocation W19723873551 @default.
• W1972387355 hasRelatedWork W2014815667 @default.
• W1972387355 hasRelatedWork W2082324743 @default.
• W1972387355 hasRelatedWork W2748952813 @default.

• next