FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972405065> ?p ?o ?g. }

• W1972405065 endingPage "3577" @default.
• W1972405065 startingPage "3570" @default.
• W1972405065 abstract "Coregulators have been suggested to act as a bridging apparatus between nuclear receptors and the transcriptional machinery. The orphan receptor SF-1 plays a role in controlling the basal and cAMP-stimulated expression of the human steroidogenic acute regulatory protein gene. DAX-1 is the gene responsible for X-linked adrenal hypoplasia congenita and blocks steroid biosynthesis by impairing the expression of steroidogenic acute regulatory protein. In the present study we examined the role of coregulators in the actions of SF-1 and DAX-1 on the human steroidogenic acute regulatory protein promoter. We found that the coregulator RIP 140 interacts with SF-1 in the yeast two-hybrid system. Glutathione-S-transferase pull-down assays and coimmunoprecipitations confirmed the interaction between RIP 140 and SF-1. RIP 140 was also shown to interact with DAX-1. When an RIP 140 expression vector was introduced into Y-1 cells, basal and cAMP-stimulated human steroidogenic acute regulatory protein promoter activities decreased. The inhibitory effect of RIP 140 on human steroidogenic acute regulatory protein promoter activity was dependent upon the presence of SF-1. The cAMP response of an SF-1 response element was inhibited by both RIP 140 and DAX-1 expression vectors at low concentrations of plasmids. We conclude that RIP 140 binds to the orphan nuclear receptor SF-1 and DAX-1 and modulates their actions on the human steroidogenic acute regulatory protein promoter." @default.
• W1972405065 created "2016-06-24" @default.
• W1972405065 creator A5009010132 @default.
• W1972405065 creator A5026442801 @default.
• W1972405065 creator A5059422840 @default.
• W1972405065 creator A5059757984 @default.
• W1972405065 creator A5078485928 @default.
• W1972405065 creator A5079410680 @default.
• W1972405065 creator A5090201638 @default.
• W1972405065 creator A5091277409 @default.
• W1972405065 date "2001-08-01" @default.
• W1972405065 modified "2023-10-02" @default.
• W1972405065 title "RIP 140 Modulates Transcription of the Steroidogenic Acute Regulatory Protein Gene through Interactions with Both SF-1 and DAX-1" @default.
• W1972405065 cites W15176748 @default.
• W1972405065 cites W1602722523 @default.
• W1972405065 cites W1660177314 @default.
• W1972405065 cites W1798563091 @default.
• W1972405065 cites W1863838411 @default.
• W1972405065 cites W1864394606 @default.
• W1972405065 cites W1968489550 @default.
• W1972405065 cites W1972732345 @default.
• W1972405065 cites W1988978443 @default.
• W1972405065 cites W1991167271 @default.
• W1972405065 cites W1999343359 @default.
• W1972405065 cites W2009443375 @default.
• W1972405065 cites W2010885000 @default.
• W1972405065 cites W2011935366 @default.
• W1972405065 cites W2013378362 @default.
• W1972405065 cites W2019771407 @default.
• W1972405065 cites W2032911088 @default.
• W1972405065 cites W2035338941 @default.
• W1972405065 cites W2039490460 @default.
• W1972405065 cites W2042901562 @default.
• W1972405065 cites W2068058799 @default.
• W1972405065 cites W2071521217 @default.
• W1972405065 cites W2072386144 @default.
• W1972405065 cites W2076143895 @default.
• W1972405065 cites W2076762200 @default.
• W1972405065 cites W2100859941 @default.
• W1972405065 cites W2101073935 @default.
• W1972405065 cites W2106876536 @default.
• W1972405065 cites W2138346779 @default.
• W1972405065 cites W2139723733 @default.
• W1972405065 cites W2148941073 @default.
• W1972405065 cites W2149865992 @default.
• W1972405065 cites W2171226274 @default.
• W1972405065 doi "https://doi.org/10.1210/endo.142.8.8309" @default.
• W1972405065 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11459805" @default.
• W1972405065 hasPublicationYear "2001" @default.
• W1972405065 type Work @default.
• W1972405065 sameAs 1972405065 @default.
• W1972405065 citedByCount "34" @default.
• W1972405065 countsByYear W19724050652012 @default.
• W1972405065 countsByYear W19724050652014 @default.
• W1972405065 countsByYear W19724050652015 @default.
• W1972405065 crossrefType "journal-article" @default.
• W1972405065 hasAuthorship W1972405065A5009010132 @default.
• W1972405065 hasAuthorship W1972405065A5026442801 @default.
• W1972405065 hasAuthorship W1972405065A5059422840 @default.
• W1972405065 hasAuthorship W1972405065A5059757984 @default.
• W1972405065 hasAuthorship W1972405065A5078485928 @default.
• W1972405065 hasAuthorship W1972405065A5079410680 @default.
• W1972405065 hasAuthorship W1972405065A5090201638 @default.
• W1972405065 hasAuthorship W1972405065A5091277409 @default.
• W1972405065 hasBestOaLocation W19724050651 @default.
• W1972405065 hasConcept C101762097 @default.
• W1972405065 hasConcept C104317684 @default.
• W1972405065 hasConcept C126322002 @default.
• W1972405065 hasConcept C134018914 @default.
• W1972405065 hasConcept C137365298 @default.
• W1972405065 hasConcept C150194340 @default.
• W1972405065 hasConcept C153911025 @default.
• W1972405065 hasConcept C165864922 @default.
• W1972405065 hasConcept C170493617 @default.
• W1972405065 hasConcept C185592680 @default.
• W1972405065 hasConcept C27153228 @default.
• W1972405065 hasConcept C2777703421 @default.
• W1972405065 hasConcept C2779670467 @default.
• W1972405065 hasConcept C55493867 @default.
• W1972405065 hasConcept C63932345 @default.
• W1972405065 hasConcept C71924100 @default.
• W1972405065 hasConcept C86339819 @default.
• W1972405065 hasConcept C86803240 @default.
• W1972405065 hasConcept C95444343 @default.
• W1972405065 hasConceptScore W1972405065C101762097 @default.
• W1972405065 hasConceptScore W1972405065C104317684 @default.
• W1972405065 hasConceptScore W1972405065C126322002 @default.
• W1972405065 hasConceptScore W1972405065C134018914 @default.
• W1972405065 hasConceptScore W1972405065C137365298 @default.
• W1972405065 hasConceptScore W1972405065C150194340 @default.
• W1972405065 hasConceptScore W1972405065C153911025 @default.
• W1972405065 hasConceptScore W1972405065C165864922 @default.
• W1972405065 hasConceptScore W1972405065C170493617 @default.
• W1972405065 hasConceptScore W1972405065C185592680 @default.
• W1972405065 hasConceptScore W1972405065C27153228 @default.
• W1972405065 hasConceptScore W1972405065C2777703421 @default.
• W1972405065 hasConceptScore W1972405065C2779670467 @default.
• W1972405065 hasConceptScore W1972405065C55493867 @default.

• next