FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972405808> ?p ?o ?g. }

• W1972405808 abstract "Background: Proinflammatory cytokines may modulate insulin signaling and contribute to systemic insulin resistance (IR). Galectin-3 (Gal-3) is a marker of myocardial fibrosis. Purpose: To investigate the relation between serum Gal-3 levels (sGal3), THF-alpha(TNFa), Nt-proBNP, HOMA index and insulin in patients with heart failure with preserved left ventricular ejection fraction (HFpEF), IR and type 2 diabetes mellitus (T2DM). Methods: Seventy four patients (40 males and 34 females; mean age 62.2768.7 years) with HFpEF with and without concomitant T2DM were examined. The sGal3, Nt-proBNP, TNF-alpha and insulin were measured in serum by ELISA, according to manufacturer’s instructions. HOmeostasis Model Assessment (HOMA) index was calculated as a measure of IR at fasting state (IR5fasting glucose fasting insulin/ 22.5), after what patients were divided into three groups: 30 patients with HFpEF and IR, 31 patients with HFpEF and T2DM and 11 patients with HFpEF and without T2DM and IR. Spearman’s correlation analysis and Kruskal-Wallis test were used. All statistical tests were 2-tailed, and p!0.05 was considered statistically significant. Results: IR was diagnosed in 31 (43.6%) patients without a history of diabetes. In the group with HFpEF and IR the level of sGal3, TNF-alpha and insulin were significantly higher compared to the HFpEF patients with T2DM and HFpEF patients without IR and T2DM (p!0.05, p!0.05 and p!0.0001 respectively) (Table 1). Therewith analyses detected that increasing of sGal3 levels associated with increasing TNFa levels (r50.610; p ! 0.001), insulin levels (r 5 0.33; p !0.01) and HOMA index (r 5 0.29; p !0.05). In addition, our data showed that the strength of relation of sGal3 and TNFa levels increased from HFpEF patients with IR (r 5 0.520) to HFpEF patients with T2DM (r 5 0.709) (p !0.05). Multiple linear regression analysis suggested a significant dependence between sGal3 and TNFa (HFpEF patients with IR and without T2DM group: r 5 0.23, p ! 0.01, HFpEF patients with T2DM group: r 5 0.76, p ! 0.0001), but the dependences between TNF and Nt-proBNP (r 5 0.37, p ! 0.01), and between sGal3 and Nt-proBNP (r 5 0.82, p ! 0.0001) was significant only in patients with IR and without T2DM. Conclusions: Our results clearly show that sGal3, TNF-alpha and insulin are significantly increased in HFpEF patients with IR and without T2DM. Our findings show the association between sGal3 levels and TNFa levels in the presence of impaired glucose tolerance in HFpEF patients. This dependence increases with the progression of IR." @default.
• W1972405808 created "2016-06-24" @default.
• W1972405808 creator A5011319488 @default.
• W1972405808 creator A5057241591 @default.
• W1972405808 date "2014-08-01" @default.
• W1972405808 modified "2023-09-27" @default.
• W1972405808 title "TNFa and Serum Galectin-3 in Patients with Heart Failure with Preserved Left Ventricular Ejection Fraction, Insulin Resistance and Type 2 Diabetes Mellitus" @default.
• W1972405808 doi "https://doi.org/10.1016/j.cardfail.2014.06.071" @default.
• W1972405808 hasPublicationYear "2014" @default.
• W1972405808 type Work @default.
• W1972405808 sameAs 1972405808 @default.
• W1972405808 citedByCount "1" @default.
• W1972405808 countsByYear W19724058082022 @default.
• W1972405808 crossrefType "journal-article" @default.
• W1972405808 hasAuthorship W1972405808A5011319488 @default.
• W1972405808 hasAuthorship W1972405808A5057241591 @default.
• W1972405808 hasConcept C126322002 @default.
• W1972405808 hasConcept C134018914 @default.
• W1972405808 hasConcept C164027704 @default.
• W1972405808 hasConcept C164705383 @default.
• W1972405808 hasConcept C2776914184 @default.
• W1972405808 hasConcept C2777099384 @default.
• W1972405808 hasConcept C2777180221 @default.
• W1972405808 hasConcept C2777391703 @default.
• W1972405808 hasConcept C2778198053 @default.
• W1972405808 hasConcept C2779306644 @default.
• W1972405808 hasConcept C2910068830 @default.
• W1972405808 hasConcept C555293320 @default.
• W1972405808 hasConcept C71924100 @default.
• W1972405808 hasConcept C78085059 @default.
• W1972405808 hasConceptScore W1972405808C126322002 @default.
• W1972405808 hasConceptScore W1972405808C134018914 @default.
• W1972405808 hasConceptScore W1972405808C164027704 @default.
• W1972405808 hasConceptScore W1972405808C164705383 @default.
• W1972405808 hasConceptScore W1972405808C2776914184 @default.
• W1972405808 hasConceptScore W1972405808C2777099384 @default.
• W1972405808 hasConceptScore W1972405808C2777180221 @default.
• W1972405808 hasConceptScore W1972405808C2777391703 @default.
• W1972405808 hasConceptScore W1972405808C2778198053 @default.
• W1972405808 hasConceptScore W1972405808C2779306644 @default.
• W1972405808 hasConceptScore W1972405808C2910068830 @default.
• W1972405808 hasConceptScore W1972405808C555293320 @default.
• W1972405808 hasConceptScore W1972405808C71924100 @default.
• W1972405808 hasConceptScore W1972405808C78085059 @default.
• W1972405808 hasLocation W19724058081 @default.
• W1972405808 hasOpenAccess W1972405808 @default.
• W1972405808 hasPrimaryLocation W19724058081 @default.
• W1972405808 hasRelatedWork W1985389284 @default.
• W1972405808 hasRelatedWork W2006878048 @default.
• W1972405808 hasRelatedWork W2062350239 @default.
• W1972405808 hasRelatedWork W2089620117 @default.
• W1972405808 hasRelatedWork W2100013046 @default.
• W1972405808 hasRelatedWork W2186722165 @default.
• W1972405808 hasRelatedWork W2315078730 @default.
• W1972405808 hasRelatedWork W2348392917 @default.
• W1972405808 hasRelatedWork W2348750352 @default.
• W1972405808 hasRelatedWork W2358130863 @default.
• W1972405808 hasRelatedWork W2372190182 @default.
• W1972405808 hasRelatedWork W2376583312 @default.
• W1972405808 hasRelatedWork W2404135105 @default.
• W1972405808 hasRelatedWork W3004564967 @default.
• W1972405808 hasRelatedWork W3029463423 @default.
• W1972405808 hasRelatedWork W3032207864 @default.
• W1972405808 hasRelatedWork W3032230744 @default.
• W1972405808 hasRelatedWork W3103138412 @default.
• W1972405808 hasRelatedWork W3194601580 @default.
• W1972405808 hasRelatedWork W848310988 @default.
• W1972405808 isParatext "false" @default.
• W1972405808 isRetracted "false" @default.
• W1972405808 magId "1972405808" @default.
• W1972405808 workType "article" @default.