Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972407391> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W1972407391 abstract "A gas chromatographic/mass spectrometric (GC/MS) method for the rapid quantitation of atropine (AT) in blood is presented. A 2.0-mL blood specimen containing deuterated N-methyl-atropine as the internal standard was alkaline-hydrolyzed to convert atropine to tropine. The tropine was extracted by organic solvent which was evaporated to dryness. Tropine in the residue was derivatized with pentafluoropropionic anhydride (PFPA) to the PFPA-tropine ester which was chromatographed on a 25-m cross-linked methyl silicone capillary column with temperature programming at 100 degrees C initially and increased by 20 degrees C/min. The retention time of atropine was 1.7 min. The GC/MS was operated in the SIM mode and the mass fragments monitored were 124 and 287 for AT and 127 and 290 for the internal standard. The assay was linear from 10-300 ng/mL. Replicate analysis of blood specimens containing 200 ng/mL gave a CV = 6.5% (n = 10). Recovery of AT at 75 and 150 ng/mL was 69% (n = 10). The limit of quantitation of AT was 10 ng/mL. Scopolamine may be simultaneously extracted and identified; the retention time was 1.8 min with mass ions 81 and 138." @default.
- W1972407391 created "2016-06-24" @default.
- W1972407391 creator A5003027471 @default.
- W1972407391 creator A5008523124 @default.
- W1972407391 date "1989-09-01" @default.
- W1972407391 modified "2023-09-26" @default.
- W1972407391 title "Determination of Atropine in Blood by Gas Chromatography/Mass Spectrometry*" @default.
- W1972407391 cites W1995297574 @default.
- W1972407391 cites W2055551089 @default.
- W1972407391 cites W2078293327 @default.
- W1972407391 cites W2085328969 @default.
- W1972407391 cites W2285531919 @default.
- W1972407391 cites W3034487035 @default.
- W1972407391 doi "https://doi.org/10.1093/jat/13.5.296" @default.
- W1972407391 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2615340" @default.
- W1972407391 hasPublicationYear "1989" @default.
- W1972407391 type Work @default.
- W1972407391 sameAs 1972407391 @default.
- W1972407391 citedByCount "14" @default.
- W1972407391 countsByYear W19724073912013 @default.
- W1972407391 countsByYear W19724073912014 @default.
- W1972407391 countsByYear W19724073912021 @default.
- W1972407391 crossrefType "journal-article" @default.
- W1972407391 hasAuthorship W1972407391A5003027471 @default.
- W1972407391 hasAuthorship W1972407391A5008523124 @default.
- W1972407391 hasConcept C119128265 @default.
- W1972407391 hasConcept C123460561 @default.
- W1972407391 hasConcept C162356407 @default.
- W1972407391 hasConcept C179302884 @default.
- W1972407391 hasConcept C185592680 @default.
- W1972407391 hasConcept C205345274 @default.
- W1972407391 hasConcept C2775859210 @default.
- W1972407391 hasConcept C2776923573 @default.
- W1972407391 hasConcept C42219234 @default.
- W1972407391 hasConcept C43617362 @default.
- W1972407391 hasConcept C71924100 @default.
- W1972407391 hasConceptScore W1972407391C119128265 @default.
- W1972407391 hasConceptScore W1972407391C123460561 @default.
- W1972407391 hasConceptScore W1972407391C162356407 @default.
- W1972407391 hasConceptScore W1972407391C179302884 @default.
- W1972407391 hasConceptScore W1972407391C185592680 @default.
- W1972407391 hasConceptScore W1972407391C205345274 @default.
- W1972407391 hasConceptScore W1972407391C2775859210 @default.
- W1972407391 hasConceptScore W1972407391C2776923573 @default.
- W1972407391 hasConceptScore W1972407391C42219234 @default.
- W1972407391 hasConceptScore W1972407391C43617362 @default.
- W1972407391 hasConceptScore W1972407391C71924100 @default.
- W1972407391 hasLocation W19724073911 @default.
- W1972407391 hasLocation W19724073912 @default.
- W1972407391 hasOpenAccess W1972407391 @default.
- W1972407391 hasPrimaryLocation W19724073911 @default.
- W1972407391 hasRelatedWork W1964054088 @default.
- W1972407391 hasRelatedWork W1964424469 @default.
- W1972407391 hasRelatedWork W2007757232 @default.
- W1972407391 hasRelatedWork W2021585491 @default.
- W1972407391 hasRelatedWork W2051188305 @default.
- W1972407391 hasRelatedWork W2072942259 @default.
- W1972407391 hasRelatedWork W2081925920 @default.
- W1972407391 hasRelatedWork W2096652817 @default.
- W1972407391 hasRelatedWork W2118349567 @default.
- W1972407391 hasRelatedWork W2169905038 @default.
- W1972407391 isParatext "false" @default.
- W1972407391 isRetracted "false" @default.
- W1972407391 magId "1972407391" @default.
- W1972407391 workType "article" @default.