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- W1972419174 endingPage "1906" @default.
- W1972419174 startingPage "1894" @default.
- W1972419174 abstract "In addition to nigrostriatal pathology and corresponding motor disturbances, Parkinson's disease (PD) is often characterized by co-morbid neuropsychiatric symptoms, most notably anxiety and depression. Separate lines of evidence indicate that inflammatory processes associated with microglial activation and cytokine release may be fundamental to the progression of both PD and its co-morbid psychiatric pathology. Accordingly, we assessed the contribution of the pro-inflammatory cytokine, interferon-gamma (IFN-γ), to a range of PD-like pathology provoked by the ecologically relevant herbicide and dopamine (DA) toxin, paraquat. To this end, paraquat provoked overt motor impairment (reduced home-cage activity and impaired vertical climbing) and signs of anxiety-like behavior (reduced open field exploration) in wild-type but not IFN-γ-deficient mice. Correspondingly, paraquat promoted somewhat divergent variations in neurochemical activity among wild-type and IFN-γ null mice at brain sites important for both motor (striatum) and co-morbid affective pathologies (dorsal hippocampus, medial prefrontal cortex, and locus coeruleus). Specifically, the herbicide provoked a dosing regimen-dependent reduction in striatal DA levels that was prevented by IFN-γ deficiency. In addition, the herbicide influenced serotonergic and noradrenergic activity within the dorsal hippocampus and medial prefrontal cortex; and elevated noradrenergic activity within the locus coeruleus. Although genetic ablation of IFN-γ had relatively few effects on monoamine variations within the locus coeruleus and prefrontal cortex, loss of the pro-inflammatory cytokine did normalize the paraquat-induced noradrenergic alterations within the hippocampus. These findings further elucidate the functional implications of paraquat intoxication and suggest an important role for IFN-γ in the striatal and motor pathology, as well as the co-morbid behavioral and hippocampal changes induced by paraquat." @default.
- W1972419174 created "2016-06-24" @default.
- W1972419174 creator A5016683463 @default.
- W1972419174 creator A5045874808 @default.
- W1972419174 creator A5046662193 @default.
- W1972419174 creator A5060205460 @default.
- W1972419174 date "2009-12-01" @default.
- W1972419174 modified "2023-10-08" @default.
- W1972419174 title "Interferon-γ deficiency modifies the motor and co-morbid behavioral pathology and neurochemical changes provoked by the pesticide paraquat" @default.
- W1972419174 cites W1237068170 @default.
- W1972419174 cites W1483007279 @default.
- W1972419174 cites W1484568938 @default.
- W1972419174 cites W1500418512 @default.
- W1972419174 cites W1504584187 @default.
- W1972419174 cites W1506563231 @default.
- W1972419174 cites W1542681400 @default.
- W1972419174 cites W1577637371 @default.
- W1972419174 cites W1584829548 @default.
- W1972419174 cites W1591724033 @default.
- W1972419174 cites W1906930390 @default.
- W1972419174 cites W1960588499 @default.
- W1972419174 cites W1966037459 @default.
- W1972419174 cites W1967617319 @default.
- W1972419174 cites W1968507832 @default.
- W1972419174 cites W1968726432 @default.
- W1972419174 cites W1971701992 @default.
- W1972419174 cites W1972912204 @default.
- W1972419174 cites W1973114962 @default.
- W1972419174 cites W1974138151 @default.
- W1972419174 cites W1974939140 @default.
- W1972419174 cites W1975331070 @default.
- W1972419174 cites W1977118330 @default.
- W1972419174 cites W1977679734 @default.
- W1972419174 cites W1977886577 @default.
- W1972419174 cites W1978200350 @default.
- W1972419174 cites W1980020952 @default.
- W1972419174 cites W1985670077 @default.
- W1972419174 cites W1987656015 @default.
- W1972419174 cites W1988814315 @default.
- W1972419174 cites W1990872391 @default.
- W1972419174 cites W1991246155 @default.
- W1972419174 cites W1993737224 @default.
- W1972419174 cites W1995303792 @default.
- W1972419174 cites W1995826981 @default.
- W1972419174 cites W1998689099 @default.
- W1972419174 cites W1999388182 @default.
- W1972419174 cites W2001176185 @default.
- W1972419174 cites W2001666803 @default.
- W1972419174 cites W2002177353 @default.
- W1972419174 cites W2003241128 @default.
- W1972419174 cites W2005408399 @default.
- W1972419174 cites W2006642289 @default.
- W1972419174 cites W2011112456 @default.
- W1972419174 cites W2011398794 @default.
- W1972419174 cites W2012769830 @default.
- W1972419174 cites W2016336099 @default.
- W1972419174 cites W2018896573 @default.
- W1972419174 cites W2019010892 @default.
- W1972419174 cites W2019817056 @default.
- W1972419174 cites W2020290141 @default.
- W1972419174 cites W2020327484 @default.
- W1972419174 cites W2020457210 @default.
- W1972419174 cites W2021620432 @default.
- W1972419174 cites W2022333195 @default.
- W1972419174 cites W2022533807 @default.
- W1972419174 cites W2024506496 @default.
- W1972419174 cites W2025842100 @default.
- W1972419174 cites W2027021803 @default.
- W1972419174 cites W2029107495 @default.
- W1972419174 cites W2030542338 @default.
- W1972419174 cites W2037152904 @default.
- W1972419174 cites W2041831342 @default.
- W1972419174 cites W2045281478 @default.
- W1972419174 cites W2046088592 @default.
- W1972419174 cites W2048570076 @default.
- W1972419174 cites W2050731687 @default.
- W1972419174 cites W2052384228 @default.
- W1972419174 cites W2052770514 @default.
- W1972419174 cites W2054028494 @default.
- W1972419174 cites W2056189993 @default.
- W1972419174 cites W2056196016 @default.
- W1972419174 cites W2056546282 @default.
- W1972419174 cites W2062605045 @default.
- W1972419174 cites W2063032404 @default.
- W1972419174 cites W2063165012 @default.
- W1972419174 cites W2064496574 @default.
- W1972419174 cites W2065665245 @default.
- W1972419174 cites W2066419788 @default.
- W1972419174 cites W2066452883 @default.
- W1972419174 cites W2066762007 @default.
- W1972419174 cites W2072092010 @default.
- W1972419174 cites W2072647996 @default.
- W1972419174 cites W2073524128 @default.
- W1972419174 cites W2074785311 @default.
- W1972419174 cites W2077360634 @default.
- W1972419174 cites W2079536916 @default.
- W1972419174 cites W2080049988 @default.
- W1972419174 cites W2080633286 @default.