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- W1972433850 abstract "SIRS, We read with interest the review article by Cunliffe and Scott,1 who propose a practical scheme for the monitoring of the main groups of drugs used in inflammatory bowel disease. However, although the authors considered the haematological, renal, hepatic and bone mineral side-effects of 5-aminosalicylates, thiopurines, methotrexate and corticosteroids, they did not consider pancreatic side-effects. The risk of pancreatic toxicity amongst patients taking thiopurines is not negligible. Drug-induced pancreatitis has been reported in 3.25% of a group of such patients, which occurred during the first 5 weeks of treatment in all but one case.2 Pancreatitis is also an absolute contraindication to continued therapy and recurs with the re-introduction of either azathioprine or mercaptopurine.3, 4 As pancreatic enzyme levels are high in 8–21% of patients with inflammatory bowel disease, and this increase is associated with more extensive and active disease,5 the monitoring of serum amylase and lipase may not be helpful in preventing pancreatic side-effects, but the possibility of drug-induced pancreatitis in the presence of acute abdominal pain during treatment should at least have been mentioned." @default.
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- W1972433850 date "2002-09-19" @default.
- W1972433850 modified "2023-10-14" @default.
- W1972433850 title "Drug side-effects in IBD" @default.
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- W1972433850 doi "https://doi.org/10.1046/j.1365-2036.2002.t01-1-01329_1.x" @default.
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