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- W1972436174 abstract "Alzheimer's disease (AD) is a neurodegenerative disorder that results in cognitive impairment. It has been proposed that deposits of beta-amyloid (Aβ) form the cores of the plaque and, subsequently, induce the activation of GSK-3β and the hyperphosphorylation of tau, resulting in cognitive impairment. Oxidative stress has been proposed to be an important factor in the pathogenesis of AD. Cyanidin 3-O-glucoside (Cy3G) is a neuroprotective antioxidant. However, the effects of Cy3G on cognition are unclear. In this paper, we show that Cy3G is protective against the Aβ-induced impairment of learning and memory, but has no effect on normal learning and memory. Moreover, we found that Gy3G attenuated the Aβ-induced tau hyperphosphorylation and GSK-3β hyperactivation observed in AD. Taken together, these results demonstrated that Cy3G can rescue the cognitive impairments that are induced by Aβ via the modulation of GSK-3β/tau, suggesting a potential therapeutic role of Cy3G in AD." @default.
- W1972436174 created "2016-06-24" @default.
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- W1972436174 date "2013-02-01" @default.
- W1972436174 modified "2023-10-03" @default.
- W1972436174 title "Protective effect of cyanidin 3-O-glucoside on beta-amyloid peptide-induced cognitive impairment in rats" @default.
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- W1972436174 doi "https://doi.org/10.1016/j.neulet.2012.12.023" @default.
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