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• W1972478083 abstract "Dense particles ranging in size between 70 and 300 Å were observed in the hepatic cell nucleoli of normal rats when the tissue was fixed in s-collidine buffered osmium tetroxide. The particles appeared in clusters of varying numbers and were embedded in the confined areas of amorphous matrix adjacent to the fibrillar component of nucleolonema. When tissue was fixed in phosphate-buffered osmium tetroxide or s-collidine-buffered glutaraldehyde the appearance of these particles was not consistent. However, the nucleoli showed distinct spherical areas of amorphous matrix which appeared to correspond to the areas of particle deposition in s-collidine-buffered osmium-fixed tissue. Dense particles of an identical nature were also found in the simplified forms of the nucleoli which were seen during the phase of adenine-induced or spontaneous recovery after ethionine injury. The identification of these particles was much easier in these latter nucleoli than in controls because of the simplicity of their configuration. Particles and areas of particle deposition appear to be distinct components of the nucleoli of rat hepatic cells, though the chemical nature and the functional significance of these particles remains unclear." @default.
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• W1972478083 date "1970-09-01" @default.
• W1972478083 modified "2023-10-17" @default.
• W1972478083 title "Intranucleolar dense particles in rat hepatic cell nucleoli" @default.
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• W1972478083 doi "https://doi.org/10.1016/s0022-5320(70)80020-x" @default.
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