Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972479491> ?p ?o ?g. }
- W1972479491 endingPage "12" @default.
- W1972479491 startingPage "9" @default.
- W1972479491 abstract "l-3,4-Dihydroxyphenylalanine (L-DOPA) is currently the most effective drug available to treat the symptoms of Parkinson's disease (PD). A limitation is that chronic administration of L-DOPA almost invariably, but not universally, leads to the development of abnormal involuntary movements, dyskinesia. Research suggests that striatal dopamine depletion is an important aetiological factor leading to dyskinesia development. However, in studies where L-DOPA was administered to normal animals and human subjects not afflicted by PD, abnormal involuntary movements were sometimes elicited. These studies are reviewed here and their potential significance for the pathophysiology of dyskinesia is discussed. It is concluded that, if striatal dopamine depletion may not be a requisite for the development of dyskinesia, it probably acts as a permissive factor, at least with the doses commonly employed in the clinic." @default.
- W1972479491 created "2016-06-24" @default.
- W1972479491 creator A5067369587 @default.
- W1972479491 date "2015-04-01" @default.
- W1972479491 modified "2023-09-30" @default.
- W1972479491 title "L-DOPA-induced dyskinesia, is striatal dopamine depletion a requisite?" @default.
- W1972479491 cites W191793173 @default.
- W1972479491 cites W1965738997 @default.
- W1972479491 cites W1965813108 @default.
- W1972479491 cites W1972361943 @default.
- W1972479491 cites W1973698406 @default.
- W1972479491 cites W1977777790 @default.
- W1972479491 cites W1978235854 @default.
- W1972479491 cites W1981379480 @default.
- W1972479491 cites W1984227696 @default.
- W1972479491 cites W1997434692 @default.
- W1972479491 cites W1999018495 @default.
- W1972479491 cites W2005232235 @default.
- W1972479491 cites W2008052775 @default.
- W1972479491 cites W2018008757 @default.
- W1972479491 cites W2020263939 @default.
- W1972479491 cites W2022520511 @default.
- W1972479491 cites W2024086397 @default.
- W1972479491 cites W2024299232 @default.
- W1972479491 cites W2025254813 @default.
- W1972479491 cites W2028861691 @default.
- W1972479491 cites W2031872837 @default.
- W1972479491 cites W2035286056 @default.
- W1972479491 cites W2040647981 @default.
- W1972479491 cites W2040922414 @default.
- W1972479491 cites W2042115553 @default.
- W1972479491 cites W2044590002 @default.
- W1972479491 cites W2047392446 @default.
- W1972479491 cites W2050385764 @default.
- W1972479491 cites W2057031112 @default.
- W1972479491 cites W2057061036 @default.
- W1972479491 cites W2061036786 @default.
- W1972479491 cites W2061632366 @default.
- W1972479491 cites W2065197060 @default.
- W1972479491 cites W2068497111 @default.
- W1972479491 cites W2070537156 @default.
- W1972479491 cites W2082578769 @default.
- W1972479491 cites W2084699300 @default.
- W1972479491 cites W2089085990 @default.
- W1972479491 cites W2090645860 @default.
- W1972479491 cites W2092926551 @default.
- W1972479491 cites W2095362051 @default.
- W1972479491 cites W2098486760 @default.
- W1972479491 cites W2106631077 @default.
- W1972479491 cites W2107758668 @default.
- W1972479491 cites W2121402157 @default.
- W1972479491 cites W2127586686 @default.
- W1972479491 cites W2131883222 @default.
- W1972479491 cites W2147841130 @default.
- W1972479491 cites W2243456881 @default.
- W1972479491 cites W2323997038 @default.
- W1972479491 cites W2329125042 @default.
- W1972479491 cites W2337142316 @default.
- W1972479491 cites W2343642992 @default.
- W1972479491 cites W2415550569 @default.
- W1972479491 cites W2415676562 @default.
- W1972479491 cites W2463012001 @default.
- W1972479491 cites W3161511225 @default.
- W1972479491 cites W81035475 @default.
- W1972479491 cites W83552848 @default.
- W1972479491 cites W85304509 @default.
- W1972479491 doi "https://doi.org/10.1016/j.jns.2015.02.041" @default.
- W1972479491 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25758471" @default.
- W1972479491 hasPublicationYear "2015" @default.
- W1972479491 type Work @default.
- W1972479491 sameAs 1972479491 @default.
- W1972479491 citedByCount "7" @default.
- W1972479491 countsByYear W19724794912016 @default.
- W1972479491 countsByYear W19724794912017 @default.
- W1972479491 countsByYear W19724794912018 @default.
- W1972479491 countsByYear W19724794912020 @default.
- W1972479491 countsByYear W19724794912021 @default.
- W1972479491 countsByYear W19724794912023 @default.
- W1972479491 crossrefType "journal-article" @default.
- W1972479491 hasAuthorship W1972479491A5067369587 @default.
- W1972479491 hasConcept C10162356 @default.
- W1972479491 hasConcept C126322002 @default.
- W1972479491 hasConcept C15224491 @default.
- W1972479491 hasConcept C15744967 @default.
- W1972479491 hasConcept C159047783 @default.
- W1972479491 hasConcept C169760540 @default.
- W1972479491 hasConcept C2776525014 @default.
- W1972479491 hasConcept C2779134260 @default.
- W1972479491 hasConcept C2779734285 @default.
- W1972479491 hasConcept C2780304432 @default.
- W1972479491 hasConcept C2780405171 @default.
- W1972479491 hasConcept C513476851 @default.
- W1972479491 hasConcept C71924100 @default.
- W1972479491 hasConcept C98274493 @default.
- W1972479491 hasConceptScore W1972479491C10162356 @default.
- W1972479491 hasConceptScore W1972479491C126322002 @default.
- W1972479491 hasConceptScore W1972479491C15224491 @default.
- W1972479491 hasConceptScore W1972479491C15744967 @default.