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- W1972499790 abstract "Allergen-specific immunotherapy (AIT) was described as a therapeutic option for the treatment of allergies > 100 years ago. It is based on administration of allergen extracts and leads to the development of clinical allergen tolerance in selected patients. According to current knowledge, AIT results in the restoration of immune tolerance toward the allergen of interest. It is mainly accompanied by the induction of regulatory and suppressive subsets of T and B cells, the production of IgG4 isotype allergen-specific blocking antibodies, and decreased inflammatory responses to allergens by effector cells in inflamed tissues. Currently, AIT is mainly applied subcutaneously or sublingually and is suitable for both children and adults for pollen, pet dander, house dust mite, and venom allergies. It not only affects rhinoconjunctival symptoms but also has documented short- and long-term benefits in asthma treatment. Clinically, a fast onset of tolerance is achieved during desensitization, with a tolerable amount of side effects. The disease modification effect leads to decreased disease severity, less drug usage, prevention of future allergen sensitizations, and a long-term curative effect. Increasing safety while maintaining or even augmenting efficiency is the main goal of research for novel vaccine development and improvement of treatment schemes in AIT. This article reviews the principles of allergen-specific immune tolerance development and the effects of AIT in the clinical context." @default.
- W1972499790 created "2016-06-24" @default.
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- W1972499790 date "2014-11-01" @default.
- W1972499790 modified "2023-09-28" @default.
- W1972499790 title "Scientific Foundations of Allergen-Specific Immunotherapy for Allergic Disease" @default.
- W1972499790 cites W1512556672 @default.
- W1972499790 cites W1548314620 @default.
- W1972499790 cites W1567449627 @default.
- W1972499790 cites W1577022278 @default.
- W1972499790 cites W1608960808 @default.
- W1972499790 cites W1658282642 @default.
- W1972499790 cites W1751105845 @default.
- W1972499790 cites W1757562214 @default.
- W1972499790 cites W1904116533 @default.
- W1972499790 cites W1963619764 @default.
- W1972499790 cites W1963778872 @default.
- W1972499790 cites W1965632450 @default.
- W1972499790 cites W1968234331 @default.
- W1972499790 cites W1976602395 @default.
- W1972499790 cites W1977919951 @default.
- W1972499790 cites W1978596588 @default.
- W1972499790 cites W1979042983 @default.
- W1972499790 cites W1979629195 @default.
- W1972499790 cites W1980806499 @default.
- W1972499790 cites W1981066263 @default.
- W1972499790 cites W1985662851 @default.
- W1972499790 cites W1985785290 @default.
- W1972499790 cites W1986864699 @default.
- W1972499790 cites W1987602227 @default.
- W1972499790 cites W1992011455 @default.
- W1972499790 cites W1992396801 @default.
- W1972499790 cites W1997120806 @default.
- W1972499790 cites W1997354360 @default.
- W1972499790 cites W1998970638 @default.
- W1972499790 cites W1999302610 @default.
- W1972499790 cites W2000665823 @default.
- W1972499790 cites W2002614529 @default.
- W1972499790 cites W2003355468 @default.
- W1972499790 cites W2007741297 @default.
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- W1972499790 cites W2014513314 @default.
- W1972499790 cites W2016063789 @default.
- W1972499790 cites W2017199648 @default.
- W1972499790 cites W2018887114 @default.
- W1972499790 cites W2028803867 @default.
- W1972499790 cites W2035023446 @default.
- W1972499790 cites W2035140755 @default.
- W1972499790 cites W2039042674 @default.
- W1972499790 cites W2041302559 @default.
- W1972499790 cites W2042015803 @default.
- W1972499790 cites W2043837854 @default.
- W1972499790 cites W2047684738 @default.
- W1972499790 cites W2050656150 @default.
- W1972499790 cites W2053991986 @default.
- W1972499790 cites W2057868114 @default.
- W1972499790 cites W2064502016 @default.
- W1972499790 cites W2065619967 @default.
- W1972499790 cites W2067324660 @default.
- W1972499790 cites W2068471769 @default.
- W1972499790 cites W2074276951 @default.
- W1972499790 cites W2075875408 @default.
- W1972499790 cites W2075942739 @default.
- W1972499790 cites W2075951089 @default.
- W1972499790 cites W2078129223 @default.
- W1972499790 cites W2079088504 @default.
- W1972499790 cites W2092836519 @default.
- W1972499790 cites W2108578856 @default.
- W1972499790 cites W2111740348 @default.
- W1972499790 cites W2117748999 @default.
- W1972499790 cites W2120764424 @default.
- W1972499790 cites W2130913584 @default.
- W1972499790 cites W2132138828 @default.
- W1972499790 cites W2142388937 @default.
- W1972499790 cites W2142537541 @default.
- W1972499790 cites W2144153485 @default.
- W1972499790 cites W2147770922 @default.
- W1972499790 cites W2149352584 @default.
- W1972499790 cites W2151458131 @default.
- W1972499790 cites W2156787187 @default.
- W1972499790 cites W2158341249 @default.
- W1972499790 cites W2166685437 @default.
- W1972499790 cites W2167319398 @default.
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- W1972499790 doi "https://doi.org/10.1378/chest.14-0049" @default.
- W1972499790 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25367471" @default.
- W1972499790 hasPublicationYear "2014" @default.
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