Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972502465> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W1972502465 endingPage "583" @default.
- W1972502465 startingPage "575" @default.
- W1972502465 abstract "Objectives: To estimate the effect of hepatitis C (HCV) coinfection on time to first occurrence of either discontinuation or modification of initial HAART among previously antiretroviral therapy-naive HIV-infected patients. Methods: The analysis included antiretroviral therapy-naive patients who initiated HAART prior to November 2003 and were participating in the University of North Carolina Center for AIDS Research, HIV/AIDS observational clinical cohort. The effect of HCV status on time to first occurrence of either HAART discontinuation or modification was assessed using Kaplan–Meier survival estimates and multivariable proportional hazards regression was used to estimate hazard ratios. Results: Of 296 patients initiating HAART, 22% were coinfected with HCV. During a median follow-up of 473 days [interquartile range (IQR), 167–940] from HAART initiation, 104 (35%) patients discontinued and 91 (31%) modified their first regimen. Reasons for discontinuation and modification were comparable by HCV serostatus and included treatment failure (12%), toxicity (41%), and barriers to adherence (47%). The median time to first occurrence of either discontinuation or modification among HCV-infected patients was 401 days (IQR, 128–821), and among HCV-uninfected patients was 493 days (IQR, 204–952) (P = 0.22). After adjustment for baseline demographic and clinical characteristics, the hazard ratio contrasting HCV-infected with HCV-uninfected patients was 1.39 (95% confidence interval, 0.95–2.03; P = 0.09). Conclusion: HCV coinfection was only marginally associated with a shorter duration of an initial HAART regimen, suggesting optimization of a first HAART regimen may not appreciably depend on HCV serostatus." @default.
- W1972502465 created "2016-06-24" @default.
- W1972502465 creator A5013525109 @default.
- W1972502465 creator A5024560316 @default.
- W1972502465 creator A5058493304 @default.
- W1972502465 creator A5067326691 @default.
- W1972502465 date "2006-02-28" @default.
- W1972502465 modified "2023-09-24" @default.
- W1972502465 title "Effect of hepatitis C coinfection on discontinuation and modification of initial HAART in primary HIV care" @default.
- W1972502465 cites W1550196875 @default.
- W1972502465 cites W1976494632 @default.
- W1972502465 cites W1985646480 @default.
- W1972502465 cites W1986859702 @default.
- W1972502465 cites W2017960775 @default.
- W1972502465 cites W2044274797 @default.
- W1972502465 cites W2047735545 @default.
- W1972502465 cites W2053452241 @default.
- W1972502465 cites W2063329141 @default.
- W1972502465 cites W2074115135 @default.
- W1972502465 cites W2075139859 @default.
- W1972502465 cites W2088613968 @default.
- W1972502465 cites W2090829051 @default.
- W1972502465 cites W2099847630 @default.
- W1972502465 cites W2100235072 @default.
- W1972502465 cites W2119222528 @default.
- W1972502465 cites W2156380404 @default.
- W1972502465 cites W2160132227 @default.
- W1972502465 cites W2327498456 @default.
- W1972502465 cites W4238075955 @default.
- W1972502465 doi "https://doi.org/10.1097/01.aids.0000210612.37589.12" @default.
- W1972502465 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16470122" @default.
- W1972502465 hasPublicationYear "2006" @default.
- W1972502465 type Work @default.
- W1972502465 sameAs 1972502465 @default.
- W1972502465 citedByCount "10" @default.
- W1972502465 countsByYear W19725024652013 @default.
- W1972502465 countsByYear W19725024652016 @default.
- W1972502465 crossrefType "journal-article" @default.
- W1972502465 hasAuthorship W1972502465A5013525109 @default.
- W1972502465 hasAuthorship W1972502465A5024560316 @default.
- W1972502465 hasAuthorship W1972502465A5058493304 @default.
- W1972502465 hasAuthorship W1972502465A5067326691 @default.
- W1972502465 hasBestOaLocation W19725024651 @default.
- W1972502465 hasConcept C119060515 @default.
- W1972502465 hasConcept C126322002 @default.
- W1972502465 hasConcept C142462285 @default.
- W1972502465 hasConcept C201903717 @default.
- W1972502465 hasConcept C203014093 @default.
- W1972502465 hasConcept C207103383 @default.
- W1972502465 hasConcept C2776455275 @default.
- W1972502465 hasConcept C2776535787 @default.
- W1972502465 hasConcept C2777813720 @default.
- W1972502465 hasConcept C2778715236 @default.
- W1972502465 hasConcept C2781413609 @default.
- W1972502465 hasConcept C3013748606 @default.
- W1972502465 hasConcept C44249647 @default.
- W1972502465 hasConcept C71924100 @default.
- W1972502465 hasConceptScore W1972502465C119060515 @default.
- W1972502465 hasConceptScore W1972502465C126322002 @default.
- W1972502465 hasConceptScore W1972502465C142462285 @default.
- W1972502465 hasConceptScore W1972502465C201903717 @default.
- W1972502465 hasConceptScore W1972502465C203014093 @default.
- W1972502465 hasConceptScore W1972502465C207103383 @default.
- W1972502465 hasConceptScore W1972502465C2776455275 @default.
- W1972502465 hasConceptScore W1972502465C2776535787 @default.
- W1972502465 hasConceptScore W1972502465C2777813720 @default.
- W1972502465 hasConceptScore W1972502465C2778715236 @default.
- W1972502465 hasConceptScore W1972502465C2781413609 @default.
- W1972502465 hasConceptScore W1972502465C3013748606 @default.
- W1972502465 hasConceptScore W1972502465C44249647 @default.
- W1972502465 hasConceptScore W1972502465C71924100 @default.
- W1972502465 hasIssue "4" @default.
- W1972502465 hasLocation W19725024651 @default.
- W1972502465 hasLocation W19725024652 @default.
- W1972502465 hasLocation W19725024653 @default.
- W1972502465 hasOpenAccess W1972502465 @default.
- W1972502465 hasPrimaryLocation W19725024651 @default.
- W1972502465 hasRelatedWork W1514920117 @default.
- W1972502465 hasRelatedWork W1519965017 @default.
- W1972502465 hasRelatedWork W2024084134 @default.
- W1972502465 hasRelatedWork W2036713093 @default.
- W1972502465 hasRelatedWork W2127785206 @default.
- W1972502465 hasRelatedWork W2129522191 @default.
- W1972502465 hasRelatedWork W2157235762 @default.
- W1972502465 hasRelatedWork W2319531643 @default.
- W1972502465 hasRelatedWork W2947523721 @default.
- W1972502465 hasRelatedWork W3037194828 @default.
- W1972502465 hasVolume "20" @default.
- W1972502465 isParatext "false" @default.
- W1972502465 isRetracted "false" @default.
- W1972502465 magId "1972502465" @default.
- W1972502465 workType "article" @default.