Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972506667> ?p ?o ?g. }
- W1972506667 endingPage "26" @default.
- W1972506667 startingPage "17" @default.
- W1972506667 abstract "We have recently shown that staurosporine (ST) can trigger apoptosis of CaSki and HeLa cervical tumor cells from G2/M checkpoint, though the mechanism remains elusive. In this study, we reported that ST induced the inhibition of E6 and E7 viral oncogene and MDM2 expression, while it led to increased levels of p53, which was transiently located to mitochondria. Additionally, the proteins of the p53-regulated genes, p21(WAF1) and Bax, were increased with a similar time, while Bcl-2 and Bcl-X(L) expression was lowered. Upon ST treatment, the cytochrome c was released into the cytosol and, then, activation of caspases-9 and -3 led to Poly(ADP)RibosePolymerase (PARP) cleavage. Finally, characteristic morphological signs confirmed the apoptosis execution. Thus, taken together, all these observations suggest that apoptosis can be reactivated in HPV-positive human carcinoma cells and highlight that ST could be used as a potently chemotherapy agent to enhance the sensitivity of tumor cells to apoptosis." @default.
- W1972506667 created "2016-06-24" @default.
- W1972506667 creator A5020514183 @default.
- W1972506667 creator A5041710269 @default.
- W1972506667 creator A5042231020 @default.
- W1972506667 creator A5082923343 @default.
- W1972506667 date "2003-01-01" @default.
- W1972506667 modified "2023-09-26" @default.
- W1972506667 title "Human papillomaviruses type 16+ and 18+ cervical carcinoma cells are sensitive to staurosporine-mediated apoptosis" @default.
- W1972506667 cites W1506642042 @default.
- W1972506667 cites W1525939857 @default.
- W1972506667 cites W1527712367 @default.
- W1972506667 cites W1557998194 @default.
- W1972506667 cites W1596165940 @default.
- W1972506667 cites W163167244 @default.
- W1972506667 cites W1745634660 @default.
- W1972506667 cites W182888219 @default.
- W1972506667 cites W1886614022 @default.
- W1972506667 cites W1949487930 @default.
- W1972506667 cites W1964617786 @default.
- W1972506667 cites W1965041925 @default.
- W1972506667 cites W196685199 @default.
- W1972506667 cites W1969290507 @default.
- W1972506667 cites W1972054148 @default.
- W1972506667 cites W1977039418 @default.
- W1972506667 cites W1977933482 @default.
- W1972506667 cites W1978810719 @default.
- W1972506667 cites W1979388308 @default.
- W1972506667 cites W1980462656 @default.
- W1972506667 cites W1981793256 @default.
- W1972506667 cites W1982687089 @default.
- W1972506667 cites W1983009674 @default.
- W1972506667 cites W1983751803 @default.
- W1972506667 cites W1984188658 @default.
- W1972506667 cites W1985111376 @default.
- W1972506667 cites W1985840237 @default.
- W1972506667 cites W1987350137 @default.
- W1972506667 cites W1987922405 @default.
- W1972506667 cites W1989589242 @default.
- W1972506667 cites W1990789249 @default.
- W1972506667 cites W1994526892 @default.
- W1972506667 cites W1997161295 @default.
- W1972506667 cites W2004706142 @default.
- W1972506667 cites W2008301561 @default.
- W1972506667 cites W2009424100 @default.
- W1972506667 cites W2011359957 @default.
- W1972506667 cites W2012307825 @default.
- W1972506667 cites W2015026645 @default.
- W1972506667 cites W2015066175 @default.
- W1972506667 cites W2016319937 @default.
- W1972506667 cites W2017293140 @default.
- W1972506667 cites W2026367694 @default.
- W1972506667 cites W2028210102 @default.
- W1972506667 cites W2034797361 @default.
- W1972506667 cites W2038753750 @default.
- W1972506667 cites W2039382131 @default.
- W1972506667 cites W2039934202 @default.
- W1972506667 cites W2040094987 @default.
- W1972506667 cites W2044079387 @default.
- W1972506667 cites W2049721676 @default.
- W1972506667 cites W2051295463 @default.
- W1972506667 cites W2052412673 @default.
- W1972506667 cites W2056530510 @default.
- W1972506667 cites W2058377017 @default.
- W1972506667 cites W2063221399 @default.
- W1972506667 cites W2066201797 @default.
- W1972506667 cites W2067336793 @default.
- W1972506667 cites W2068829557 @default.
- W1972506667 cites W2076104235 @default.
- W1972506667 cites W2082979850 @default.
- W1972506667 cites W2085593164 @default.
- W1972506667 cites W2094126824 @default.
- W1972506667 cites W2095014345 @default.
- W1972506667 cites W2097447643 @default.
- W1972506667 cites W2098316409 @default.
- W1972506667 cites W2099907467 @default.
- W1972506667 cites W2100047578 @default.
- W1972506667 cites W2108398180 @default.
- W1972506667 cites W2113895705 @default.
- W1972506667 cites W2113999599 @default.
- W1972506667 cites W2117401730 @default.
- W1972506667 cites W2119512929 @default.
- W1972506667 cites W2120939161 @default.
- W1972506667 cites W2121619780 @default.
- W1972506667 cites W2131677957 @default.
- W1972506667 cites W2135535670 @default.
- W1972506667 cites W2136306650 @default.
- W1972506667 cites W2138102966 @default.
- W1972506667 cites W2143103843 @default.
- W1972506667 cites W2145224950 @default.
- W1972506667 cites W2149703879 @default.
- W1972506667 cites W2150668123 @default.
- W1972506667 cites W2150710841 @default.
- W1972506667 cites W2152160266 @default.
- W1972506667 cites W2170431739 @default.
- W1972506667 cites W2277772680 @default.
- W1972506667 cites W2318683859 @default.
- W1972506667 cites W2324975577 @default.