FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972506687> ?p ?o ?g. }

• W1972506687 endingPage "287" @default.
• W1972506687 startingPage "283" @default.
• W1972506687 abstract "In the present study, the effect of medroxyprogesterone (MPA) is evaluated for its effect on pentylenetetrazole (PTZ) kindling model of epileptogenesis in mice followed by evaluation on kindling-induced changes in cognitive and motor functions. To explore whether the effects are mediated via progesterone receptors, a selective antagonist of progesterone (mifepristone, MIF) was also taken. Kindling was induced by once every 2 days treatment with PTZ (25 mg/kg, i.p.) for 5 weeks. The seizure severity during induction of kindling and % incidence of animals kindled at the end of 5 weeks were recorded. The motor function was assessed using a grip strength meter, whereas spatial memory was assessed in a cross maze. MPA (5 and 10 mg/kg, i.p.) significantly reduced the seizure severity scores and produced a significant decrease in the incidence of animals kindled at the end of 5 weeks (P<0.01). A higher efficacy was observed against male mice as compared with females following MPA. MIF neither reduced nor delayed the development of PTZ-induced kindling in mice. Also, it couldn't reverse the antiepileptogenic effects of MPA. On grip strength test (GST) and spontaneous alternation behavior (SAB), a significant decline in GST and % alternation was observed in kindled mice which was reversed by pre-treatment with MPA. MIF, however, could reverse only the reduced % alternation and not grip strength (GS) in PTZ-kindled animals. The study shows that MPA has antiepileptogenic effects against development of PTZ-induced kindling in mice that may not be mediated via progesterone receptors." @default.
• W1972506687 created "2016-06-24" @default.
• W1972506687 creator A5019144480 @default.
• W1972506687 creator A5035937945 @default.
• W1972506687 creator A5041028410 @default.
• W1972506687 creator A5088609161 @default.
• W1972506687 date "2012-04-01" @default.
• W1972506687 modified "2023-10-02" @default.
• W1972506687 title "Effect of medroxyprogesterone on development of pentylenetetrazole-induced kindling in mice" @default.
• W1972506687 cites W1575237772 @default.
• W1972506687 cites W1969750257 @default.
• W1972506687 cites W1971000309 @default.
• W1972506687 cites W1979062320 @default.
• W1972506687 cites W1983034344 @default.
• W1972506687 cites W1984368514 @default.
• W1972506687 cites W1989754860 @default.
• W1972506687 cites W1993698157 @default.
• W1972506687 cites W1997011871 @default.
• W1972506687 cites W1997932302 @default.
• W1972506687 cites W2000127517 @default.
• W1972506687 cites W2005497343 @default.
• W1972506687 cites W2007328843 @default.
• W1972506687 cites W2009374844 @default.
• W1972506687 cites W2013777991 @default.
• W1972506687 cites W2023261925 @default.
• W1972506687 cites W2024247977 @default.
• W1972506687 cites W2026011062 @default.
• W1972506687 cites W2029183173 @default.
• W1972506687 cites W2031161633 @default.
• W1972506687 cites W2037451512 @default.
• W1972506687 cites W2046600920 @default.
• W1972506687 cites W2050736164 @default.
• W1972506687 cites W2056079117 @default.
• W1972506687 cites W2069327573 @default.
• W1972506687 cites W2071924525 @default.
• W1972506687 cites W2079850280 @default.
• W1972506687 cites W2081483657 @default.
• W1972506687 cites W2084038858 @default.
• W1972506687 cites W2093502520 @default.
• W1972506687 cites W2102858241 @default.
• W1972506687 cites W2113179569 @default.
• W1972506687 cites W2131651771 @default.
• W1972506687 cites W2143258558 @default.
• W1972506687 cites W2158204588 @default.
• W1972506687 doi "https://doi.org/10.1016/j.neuroscience.2012.01.031" @default.
• W1972506687 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22314318" @default.
• W1972506687 hasPublicationYear "2012" @default.
• W1972506687 type Work @default.
• W1972506687 sameAs 1972506687 @default.
• W1972506687 citedByCount "7" @default.
• W1972506687 countsByYear W19725066872013 @default.
• W1972506687 countsByYear W19725066872014 @default.
• W1972506687 countsByYear W19725066872015 @default.
• W1972506687 countsByYear W19725066872020 @default.
• W1972506687 countsByYear W19725066872021 @default.
• W1972506687 crossrefType "journal-article" @default.
• W1972506687 hasAuthorship W1972506687A5019144480 @default.
• W1972506687 hasAuthorship W1972506687A5035937945 @default.
• W1972506687 hasAuthorship W1972506687A5041028410 @default.
• W1972506687 hasAuthorship W1972506687A5088609161 @default.
• W1972506687 hasConcept C100691959 @default.
• W1972506687 hasConcept C126322002 @default.
• W1972506687 hasConcept C134018914 @default.
• W1972506687 hasConcept C185592680 @default.
• W1972506687 hasConcept C24998067 @default.
• W1972506687 hasConcept C2775934596 @default.
• W1972506687 hasConcept C2776306185 @default.
• W1972506687 hasConcept C2777164284 @default.
• W1972506687 hasConcept C2778302826 @default.
• W1972506687 hasConcept C2778826759 @default.
• W1972506687 hasConcept C2779234561 @default.
• W1972506687 hasConcept C2781161787 @default.
• W1972506687 hasConcept C54355233 @default.
• W1972506687 hasConcept C57236427 @default.
• W1972506687 hasConcept C71924100 @default.
• W1972506687 hasConcept C86803240 @default.
• W1972506687 hasConcept C98274493 @default.
• W1972506687 hasConceptScore W1972506687C100691959 @default.
• W1972506687 hasConceptScore W1972506687C126322002 @default.
• W1972506687 hasConceptScore W1972506687C134018914 @default.
• W1972506687 hasConceptScore W1972506687C185592680 @default.
• W1972506687 hasConceptScore W1972506687C24998067 @default.
• W1972506687 hasConceptScore W1972506687C2775934596 @default.
• W1972506687 hasConceptScore W1972506687C2776306185 @default.
• W1972506687 hasConceptScore W1972506687C2777164284 @default.
• W1972506687 hasConceptScore W1972506687C2778302826 @default.
• W1972506687 hasConceptScore W1972506687C2778826759 @default.
• W1972506687 hasConceptScore W1972506687C2779234561 @default.
• W1972506687 hasConceptScore W1972506687C2781161787 @default.
• W1972506687 hasConceptScore W1972506687C54355233 @default.
• W1972506687 hasConceptScore W1972506687C57236427 @default.
• W1972506687 hasConceptScore W1972506687C71924100 @default.
• W1972506687 hasConceptScore W1972506687C86803240 @default.
• W1972506687 hasConceptScore W1972506687C98274493 @default.
• W1972506687 hasLocation W19725066871 @default.
• W1972506687 hasLocation W19725066872 @default.
• W1972506687 hasOpenAccess W1972506687 @default.
• W1972506687 hasPrimaryLocation W19725066871 @default.

• next