Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972507060> ?p ?o ?g. }
- W1972507060 endingPage "7" @default.
- W1972507060 startingPage "1" @default.
- W1972507060 abstract "The urokinase-type plasminogen activator receptor (uPAR) has been implicated in several processes in tumor progression including cell migration and invasion in addition to initiation of signal transduction. Since uPAR lacks a transmembrane domain, it uses the interaction with other proteins to modulate intracellular signal transduction. We have previously identified hSpry1 as a partner protein of uPAR, suggesting a physiological role for hSpry1 in the regulation of uPAR signal transduction. In this study, hSpry1 was found to colocalize with uPAR upon stimulation with epidermal growth factor (EGF), urokinase (uPA), or its amino terminal fragment (uPA-ATF), implicating a physiological role of hSpry1 in regulation of uPAR signalling pathway. Moreover, hSpry1 was able to inhibit uPAR-stimulated cell migration in HEK293/uPAR, breast carcinoma, and colorectal carcinoma cells. In addition, hSpry1 was found to inhibit uPAR-stimulated cell invasion in breast carcinoma and osteosarcoma cell lines. Increasing our understanding of how hSpry1 negatively regulates uPAR-stimulated cellular functions may determine a distinctive role for hSpry1 in tumour suppression." @default.
- W1972507060 created "2016-06-24" @default.
- W1972507060 creator A5039574489 @default.
- W1972507060 creator A5091058607 @default.
- W1972507060 date "2013-09-12" @default.
- W1972507060 modified "2023-10-18" @default.
- W1972507060 title "Human Sprouty1 Suppresses Urokinase Receptor-Stimulated Cell Migration and Invasion" @default.
- W1972507060 cites W1591097516 @default.
- W1972507060 cites W1974509830 @default.
- W1972507060 cites W1977745176 @default.
- W1972507060 cites W1977942359 @default.
- W1972507060 cites W1978266089 @default.
- W1972507060 cites W1986241068 @default.
- W1972507060 cites W2003593894 @default.
- W1972507060 cites W2013523876 @default.
- W1972507060 cites W2014649878 @default.
- W1972507060 cites W2015314629 @default.
- W1972507060 cites W2018557043 @default.
- W1972507060 cites W2020292268 @default.
- W1972507060 cites W2029167088 @default.
- W1972507060 cites W2036537825 @default.
- W1972507060 cites W2039445887 @default.
- W1972507060 cites W2042155824 @default.
- W1972507060 cites W2049404258 @default.
- W1972507060 cites W2050668663 @default.
- W1972507060 cites W2063352803 @default.
- W1972507060 cites W2076861604 @default.
- W1972507060 cites W2076894266 @default.
- W1972507060 cites W2082773871 @default.
- W1972507060 cites W2088921555 @default.
- W1972507060 cites W2093150302 @default.
- W1972507060 cites W2095871387 @default.
- W1972507060 cites W2103721358 @default.
- W1972507060 cites W2107633226 @default.
- W1972507060 cites W2115657003 @default.
- W1972507060 cites W2123978931 @default.
- W1972507060 cites W2125190135 @default.
- W1972507060 cites W2129628999 @default.
- W1972507060 cites W2133183478 @default.
- W1972507060 cites W2136449652 @default.
- W1972507060 cites W2143415621 @default.
- W1972507060 cites W2150102277 @default.
- W1972507060 cites W2150168131 @default.
- W1972507060 cites W2152391708 @default.
- W1972507060 cites W2170462527 @default.
- W1972507060 cites W4241478096 @default.
- W1972507060 cites W532652695 @default.
- W1972507060 doi "https://doi.org/10.1155/2013/598251" @default.
- W1972507060 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4393002" @default.
- W1972507060 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25937961" @default.
- W1972507060 hasPublicationYear "2013" @default.
- W1972507060 type Work @default.
- W1972507060 sameAs 1972507060 @default.
- W1972507060 citedByCount "6" @default.
- W1972507060 countsByYear W19725070602014 @default.
- W1972507060 countsByYear W19725070602015 @default.
- W1972507060 countsByYear W19725070602018 @default.
- W1972507060 countsByYear W19725070602022 @default.
- W1972507060 crossrefType "journal-article" @default.
- W1972507060 hasAuthorship W1972507060A5039574489 @default.
- W1972507060 hasAuthorship W1972507060A5091058607 @default.
- W1972507060 hasBestOaLocation W19725070601 @default.
- W1972507060 hasConcept C137738243 @default.
- W1972507060 hasConcept C1491633281 @default.
- W1972507060 hasConcept C170493617 @default.
- W1972507060 hasConcept C185592680 @default.
- W1972507060 hasConcept C502942594 @default.
- W1972507060 hasConcept C55493867 @default.
- W1972507060 hasConcept C56219504 @default.
- W1972507060 hasConcept C62478195 @default.
- W1972507060 hasConcept C86803240 @default.
- W1972507060 hasConcept C95444343 @default.
- W1972507060 hasConceptScore W1972507060C137738243 @default.
- W1972507060 hasConceptScore W1972507060C1491633281 @default.
- W1972507060 hasConceptScore W1972507060C170493617 @default.
- W1972507060 hasConceptScore W1972507060C185592680 @default.
- W1972507060 hasConceptScore W1972507060C502942594 @default.
- W1972507060 hasConceptScore W1972507060C55493867 @default.
- W1972507060 hasConceptScore W1972507060C56219504 @default.
- W1972507060 hasConceptScore W1972507060C62478195 @default.
- W1972507060 hasConceptScore W1972507060C86803240 @default.
- W1972507060 hasConceptScore W1972507060C95444343 @default.
- W1972507060 hasLocation W19725070601 @default.
- W1972507060 hasLocation W19725070602 @default.
- W1972507060 hasLocation W19725070603 @default.
- W1972507060 hasLocation W19725070604 @default.
- W1972507060 hasOpenAccess W1972507060 @default.
- W1972507060 hasPrimaryLocation W19725070601 @default.
- W1972507060 hasRelatedWork W1911369697 @default.
- W1972507060 hasRelatedWork W1984207930 @default.
- W1972507060 hasRelatedWork W1999270569 @default.
- W1972507060 hasRelatedWork W2031229219 @default.
- W1972507060 hasRelatedWork W2034527578 @default.
- W1972507060 hasRelatedWork W2105398191 @default.
- W1972507060 hasRelatedWork W2169823449 @default.
- W1972507060 hasRelatedWork W2367184548 @default.
- W1972507060 hasRelatedWork W2590816770 @default.
- W1972507060 hasRelatedWork W3023126620 @default.