FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972509721> ?p ?o ?g. }

• W1972509721 endingPage "112" @default.
• W1972509721 startingPage "102" @default.
• W1972509721 abstract "The resolution of an intracerebral hemorrhage can be measured by the occurrence of hemosiderin. Extravasation of blood elicits a cellular reaction in the adjacent surviving tissue where the lesion activates resident microglia and attracts many more phagocytes from the blood stream. The signals for this migration into the perifocal reactive zone are not fully understood but it is likely that proteins in the coagulated blood contribute to cellular activation. In order to study the role of plasma proteins in the pathogenesis of the perifocal reactive zone, intracerebral injections of either autologous whole blood (0.1 ml) or an equal volume of washed autologous red blood cells (RBC) in lactated Ringer's solution were made in adult rabbits. The amount of total iron was the same (30 μg). The cellular responses to the injections were studied by iron histochemistry and immunocytochemistry for ferritin, the ferritin repressor protein (FRP), the glial fibrillary acidic protein (GFAP), and the complement receptor CR3. Experimental hematomas resolved much more slowly after the injection of whole blood than after the injection of RBC. Qualitative microglial and astrocytic responses were quite similar. However, at 48 h, iron- and ferritin-reactive microglia were more numerous following the injection of whole blood. After injections of either type, ferritin-immunoreactive cells were more abundant than iron-positive cells. This observation implied that the biosynthesis of holoferritin protein and iron incorporation proceeded independently. Expression of CR3 on the surface of microglia was much more prominent after whole blood, suggesting a role of inactivated complement 3b in the attraction of additional phagocytes. Conversion to hemosiderin began at 5 days after the injection of either blood or RBC. The lesions caused initial destruction of astrocytes in the perifocal zone as judged by GFAP- and FRP-immunoreactivity. However, at 5 days, astrocytic processes reentered the perifocal zone and intermingled with microglia and macrophages. It is proposed that this contact between astrocytes and microglia reversed the uncoupling of ferritin biosynthesis and iron incorporation and initiated the storage of iron and formation of hemosiderin." @default.
• W1972509721 created "2016-06-24" @default.
• W1972509721 creator A5055416018 @default.
• W1972509721 creator A5062004674 @default.
• W1972509721 creator A5088009058 @default.
• W1972509721 date "1995-12-01" @default.
• W1972509721 modified "2023-10-11" @default.
• W1972509721 title "The cellular reactions to experimental intracerebral hemorrhage" @default.
• W1972509721 cites W1510412284 @default.
• W1972509721 cites W1511180136 @default.
• W1972509721 cites W1513908444 @default.
• W1972509721 cites W1568329054 @default.
• W1972509721 cites W1578612512 @default.
• W1972509721 cites W1964643843 @default.
• W1972509721 cites W1969467371 @default.
• W1972509721 cites W1978966935 @default.
• W1972509721 cites W1980551429 @default.
• W1972509721 cites W2009512469 @default.
• W1972509721 cites W2012066718 @default.
• W1972509721 cites W2015945020 @default.
• W1972509721 cites W2017164910 @default.
• W1972509721 cites W2025503583 @default.
• W1972509721 cites W2029231027 @default.
• W1972509721 cites W2041224079 @default.
• W1972509721 cites W2054286408 @default.
• W1972509721 cites W2058229963 @default.
• W1972509721 cites W2060056050 @default.
• W1972509721 cites W2065964744 @default.
• W1972509721 cites W2070954380 @default.
• W1972509721 cites W2071394393 @default.
• W1972509721 cites W2075584689 @default.
• W1972509721 cites W2079424517 @default.
• W1972509721 cites W2089676648 @default.
• W1972509721 cites W2096428903 @default.
• W1972509721 cites W2099446928 @default.
• W1972509721 cites W2122400789 @default.
• W1972509721 cites W2124077054 @default.
• W1972509721 cites W2124433916 @default.
• W1972509721 cites W2134333028 @default.
• W1972509721 cites W2145394664 @default.
• W1972509721 cites W2315182483 @default.
• W1972509721 cites W2516306668 @default.
• W1972509721 doi "https://doi.org/10.1016/0022-510x(95)00215-n" @default.
• W1972509721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8847540" @default.
• W1972509721 hasPublicationYear "1995" @default.
• W1972509721 type Work @default.
• W1972509721 sameAs 1972509721 @default.
• W1972509721 citedByCount "95" @default.
• W1972509721 countsByYear W19725097212012 @default.
• W1972509721 countsByYear W19725097212013 @default.
• W1972509721 countsByYear W19725097212014 @default.
• W1972509721 countsByYear W19725097212016 @default.
• W1972509721 countsByYear W19725097212017 @default.
• W1972509721 countsByYear W19725097212019 @default.
• W1972509721 countsByYear W19725097212020 @default.
• W1972509721 countsByYear W19725097212021 @default.
• W1972509721 countsByYear W19725097212022 @default.
• W1972509721 countsByYear W19725097212023 @default.
• W1972509721 crossrefType "journal-article" @default.
• W1972509721 hasAuthorship W1972509721A5055416018 @default.
• W1972509721 hasAuthorship W1972509721A5062004674 @default.
• W1972509721 hasAuthorship W1972509721A5088009058 @default.
• W1972509721 hasConcept C126322002 @default.
• W1972509721 hasConcept C142724271 @default.
• W1972509721 hasConcept C1621761 @default.
• W1972509721 hasConcept C185592680 @default.
• W1972509721 hasConcept C203014093 @default.
• W1972509721 hasConcept C204232928 @default.
• W1972509721 hasConcept C2776914184 @default.
• W1972509721 hasConcept C2777094939 @default.
• W1972509721 hasConcept C2777478355 @default.
• W1972509721 hasConcept C2777736543 @default.
• W1972509721 hasConcept C2778319317 @default.
• W1972509721 hasConcept C2779540182 @default.
• W1972509721 hasConcept C2779830541 @default.
• W1972509721 hasConcept C2780495277 @default.
• W1972509721 hasConcept C2780942790 @default.
• W1972509721 hasConcept C71924100 @default.
• W1972509721 hasConcept C86803240 @default.
• W1972509721 hasConceptScore W1972509721C126322002 @default.
• W1972509721 hasConceptScore W1972509721C142724271 @default.
• W1972509721 hasConceptScore W1972509721C1621761 @default.
• W1972509721 hasConceptScore W1972509721C185592680 @default.
• W1972509721 hasConceptScore W1972509721C203014093 @default.
• W1972509721 hasConceptScore W1972509721C204232928 @default.
• W1972509721 hasConceptScore W1972509721C2776914184 @default.
• W1972509721 hasConceptScore W1972509721C2777094939 @default.
• W1972509721 hasConceptScore W1972509721C2777478355 @default.
• W1972509721 hasConceptScore W1972509721C2777736543 @default.
• W1972509721 hasConceptScore W1972509721C2778319317 @default.
• W1972509721 hasConceptScore W1972509721C2779540182 @default.
• W1972509721 hasConceptScore W1972509721C2779830541 @default.
• W1972509721 hasConceptScore W1972509721C2780495277 @default.
• W1972509721 hasConceptScore W1972509721C2780942790 @default.
• W1972509721 hasConceptScore W1972509721C71924100 @default.
• W1972509721 hasConceptScore W1972509721C86803240 @default.
• W1972509721 hasLocation W19725097211 @default.
• W1972509721 hasLocation W19725097212 @default.

• next