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- W1972511150 abstract "Abstract The effects of low (0.2) and high (20 μg ml−1) concentrations of (±)- and (+)-propranolol, (±)-, (+)- and (-)-sotalol and guanethidine were tested for their ability to reduce responses to sympathetic stimulation in the isolated vas deferens preparation from the guinea-pig. At 0.2 μf ml−1 all drugs produced a slowly developing reduction in the responses to sympathetic stimulation while responses to noradrenaline were largely unchanged. The blockade, which was similar in extent in all six compounds, was reversed by (+)-amphetamine but not by washing. With high concentrations of and (±)-propranolol and guanethidine, the block was rapid in onset and rate and responses to noradrenaline were potentiated. The block was reversed by washing and unaffected by (+)-***amphetamine. Sotalol and its isomers, which possess little non-specific depressant activity, had qualitatively similar actions at 0.2 and 20 μg ml−1. At the latter concentration responses to noradrenaline were potentiated. The results suggest that low concentrations of the β-adrenoceptor antagonists produce a blockade which is typical of guanethidine-like drugs. At high concentrations non-specific depressant (local anaesthetic) actions of propranolol and its isomers are largely responsible for the blockade. A similar mechanism may also operate when high concentrations of guanethidine are used." @default.
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- W1972511150 date "1973-03-01" @default.
- W1972511150 modified "2023-10-09" @default.
- W1972511150 title "Further studies on the adrenergic neuron blocking activity of some β-adrenoceptor antagonists and guanethidine" @default.
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- W1972511150 doi "https://doi.org/10.1111/j.2042-7158.1973.tb10627.x" @default.
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