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- W1972520669 abstract "Methylprednisolone suleptanate was initially labeled with tritium in the A-ring of the steroid portion of the molecule, and with carbon-14 at both carboxylic carbons of the suberic acid portion of the side chain. However these labels proved to lack total metabolic stability after administration to rats. Subsequently a second pair of labeled methylprednisolone suleptanates was synthesized, with tritium at C-7 in the B-ring of the steroid and carbon-14 exclusively at the carboxamide carbon in the side chain. These labeled compounds showed excellent metabolic stability of both the tritium and carbon-14 labels, and should be well suited for conducting drug disposition studies." @default.
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- W1972520669 date "1990-05-01" @default.
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- W1972520669 title "Synthesis of carbon-14 and tritium labeled methylprednisolone suleptanate" @default.
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- W1972520669 doi "https://doi.org/10.1002/jlcr.2580280507" @default.
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