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• W1972529713 abstract "The apolipoprotein E (APOE) gene plays a pivotal role in cholesterol metabolism. Since the discovery of the APOE*2 and APOE*4 as the major susceptibility alleles for several diseases including dyslipidemia, atherosclerosis, coronary heart disease, late-onset and early Alzheimer's disease, the APOE genotype might be considered as a potential predictive factor for both epidemiological research and diagnosis.The aim of this study is to report on the polymorphism of the APOE gene in the Paisa population from northwest Colombia (Antioquia) to obtain a population baseline of the existing variation in this locus.One thousand and one healthy voluntaries were genotyped for the APOE polymorphism using polymerase chain reaction-restriction fragment length polymorphism technique.The APOE*3/*3 genotype presented the highest frequency (66.33%) and the APOE*4/*4 had the lowest frequency (1.89%). Genotype frequencies comply with Hardy-Weinberg expectations. Allele frequencies obtained for APOE*2, APOE*3 and APOE*4 were 0.075 ± 0.005 (95% CI = 0.063-0.086), 0.814 ± 0.009 (0.797-0.831) and 0.111 ± 0.007 (0.098-0.125), respectively.Although globally the high-to-low APOE frequency follows the E*3 > E*4 > E*2 trend, the present APOE frequency data is in disagreement with some reports from South-American countries." @default.
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• W1972529713 date "2014-07-15" @default.
• W1972529713 modified "2023-10-14" @default.
• W1972529713 title "Distribution ofAPOEpolymorphism in the “Paisa” population from northwest Colombia (Antioquia)" @default.
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• W1972529713 doi "https://doi.org/10.3109/03014460.2014.932846" @default.
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