Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972545796> ?p ?o ?g. }
- W1972545796 endingPage "e32705" @default.
- W1972545796 startingPage "e32705" @default.
- W1972545796 abstract "Transforming growth factor-β1 (TGF-β1) is an important anti-inflammatory cytokine that modulates and resolves inflammatory responses. Recent studies have demonstrated that inflammation enhances neoplastic risk and potentiates tumor progression. In the evolution of cancer, pro-inflammatory cytokines such as IL-1β must overcome the anti-inflammatory effects of TGF-β to boost pro-inflammatory responses in epithelial cells. Here we show that IL-1β or Lipopolysaccharide (LPS) suppresses TGF-β-induced anti-inflammatory signaling in a NF-κB-independent manner. TRAF6, a key molecule in IL-1β signaling, mediates this suppressive effect through interaction with the type III TGF-β receptor (TβRIII), which is TGF-β-dependent and requires type I TGF-β receptor (TβRI) kinase activity. TβRI phosphorylates TβRIII at residue S829, which promotes the TRAF6/TβRIII interaction and consequent sequestration of TβRIII from the TβRII/TβRI complex. Our data indicate that IL-1β enhances the pro-inflammatory response by suppressing TGF-βsignaling through TRAF6-mediated sequestration of TβRIII, which may be an important contributor to the early stages of tumor progression." @default.
- W1972545796 created "2016-06-24" @default.
- W1972545796 creator A5000114099 @default.
- W1972545796 creator A5002922209 @default.
- W1972545796 creator A5006159095 @default.
- W1972545796 creator A5007471022 @default.
- W1972545796 creator A5017162863 @default.
- W1972545796 creator A5032308371 @default.
- W1972545796 creator A5035073181 @default.
- W1972545796 creator A5053465447 @default.
- W1972545796 creator A5054489042 @default.
- W1972545796 creator A5056628655 @default.
- W1972545796 creator A5063899172 @default.
- W1972545796 creator A5064711713 @default.
- W1972545796 creator A5086811942 @default.
- W1972545796 creator A5091034692 @default.
- W1972545796 date "2012-03-12" @default.
- W1972545796 modified "2023-10-16" @default.
- W1972545796 title "TRAF6 Mediates IL-1β/LPS-Induced Suppression of TGF-β Signaling through Its Interaction with the Type III TGF-β Receptor" @default.
- W1972545796 cites W1965037168 @default.
- W1972545796 cites W1967582330 @default.
- W1972545796 cites W1978146894 @default.
- W1972545796 cites W1992496728 @default.
- W1972545796 cites W1992945893 @default.
- W1972545796 cites W1994560336 @default.
- W1972545796 cites W2006486411 @default.
- W1972545796 cites W2007456673 @default.
- W1972545796 cites W2008869198 @default.
- W1972545796 cites W2019166246 @default.
- W1972545796 cites W2030615446 @default.
- W1972545796 cites W2046412303 @default.
- W1972545796 cites W2050516456 @default.
- W1972545796 cites W2051762584 @default.
- W1972545796 cites W2056402897 @default.
- W1972545796 cites W2060652817 @default.
- W1972545796 cites W2066594663 @default.
- W1972545796 cites W2067875575 @default.
- W1972545796 cites W2080458188 @default.
- W1972545796 cites W2092404030 @default.
- W1972545796 cites W2092956762 @default.
- W1972545796 cites W2111949892 @default.
- W1972545796 cites W2114650700 @default.
- W1972545796 cites W2118986158 @default.
- W1972545796 cites W2135299943 @default.
- W1972545796 cites W2144648254 @default.
- W1972545796 cites W2148392040 @default.
- W1972545796 cites W2151268204 @default.
- W1972545796 cites W2152876200 @default.
- W1972545796 cites W2165243809 @default.
- W1972545796 cites W2315613727 @default.
- W1972545796 cites W2316067769 @default.
- W1972545796 cites W4297022993 @default.
- W1972545796 doi "https://doi.org/10.1371/journal.pone.0032705" @default.
- W1972545796 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3299683" @default.
- W1972545796 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22427868" @default.
- W1972545796 hasPublicationYear "2012" @default.
- W1972545796 type Work @default.
- W1972545796 sameAs 1972545796 @default.
- W1972545796 citedByCount "18" @default.
- W1972545796 countsByYear W19725457962013 @default.
- W1972545796 countsByYear W19725457962014 @default.
- W1972545796 countsByYear W19725457962015 @default.
- W1972545796 countsByYear W19725457962016 @default.
- W1972545796 countsByYear W19725457962017 @default.
- W1972545796 countsByYear W19725457962018 @default.
- W1972545796 countsByYear W19725457962019 @default.
- W1972545796 countsByYear W19725457962021 @default.
- W1972545796 countsByYear W19725457962022 @default.
- W1972545796 crossrefType "journal-article" @default.
- W1972545796 hasAuthorship W1972545796A5000114099 @default.
- W1972545796 hasAuthorship W1972545796A5002922209 @default.
- W1972545796 hasAuthorship W1972545796A5006159095 @default.
- W1972545796 hasAuthorship W1972545796A5007471022 @default.
- W1972545796 hasAuthorship W1972545796A5017162863 @default.
- W1972545796 hasAuthorship W1972545796A5032308371 @default.
- W1972545796 hasAuthorship W1972545796A5035073181 @default.
- W1972545796 hasAuthorship W1972545796A5053465447 @default.
- W1972545796 hasAuthorship W1972545796A5054489042 @default.
- W1972545796 hasAuthorship W1972545796A5056628655 @default.
- W1972545796 hasAuthorship W1972545796A5063899172 @default.
- W1972545796 hasAuthorship W1972545796A5064711713 @default.
- W1972545796 hasAuthorship W1972545796A5086811942 @default.
- W1972545796 hasAuthorship W1972545796A5091034692 @default.
- W1972545796 hasBestOaLocation W19725457961 @default.
- W1972545796 hasConcept C118131993 @default.
- W1972545796 hasConcept C170493617 @default.
- W1972545796 hasConcept C17991360 @default.
- W1972545796 hasConcept C185592680 @default.
- W1972545796 hasConcept C203014093 @default.
- W1972545796 hasConcept C2776914184 @default.
- W1972545796 hasConcept C2778690821 @default.
- W1972545796 hasConcept C2778754761 @default.
- W1972545796 hasConcept C502942594 @default.
- W1972545796 hasConcept C55493867 @default.
- W1972545796 hasConcept C62478195 @default.
- W1972545796 hasConcept C86803240 @default.
- W1972545796 hasConcept C95444343 @default.
- W1972545796 hasConceptScore W1972545796C118131993 @default.