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• W1972565370 endingPage "2057" @default.
• W1972565370 startingPage "2050" @default.
• W1972565370 abstract "[Gd@C82(OH)22]n particles (22 nm in a saline solution) of a dose level as low as 10-7 mol/kg exhibit a very high antineoplastic efficiency (∼60%) in mice. A dose increment of 1 × 10-7 mol/kg increases the tumor inhibition rate 26%. [Gd@C82(OH)22]n particles have a strong capacity to improve immunity and interfere with tumor invasion in normal muscle cells, nearly without toxicity in vivo and in vitro. Unlike conventional antineoplastic chemicals, the high antitumor efficiency of nanoparticles is not due to toxic effects to cells because they do not kill the tumor cells directly and only about 0.05% of the used dose is found in the tumor tissues. Results suggest that fullerene derivatives with proper surface modifications and sizes may help realize the dream of tumor chemotherapeutics of high-efficacy and low-toxicity." @default.
• W1972565370 created "2016-06-24" @default.
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• W1972565370 date "2005-09-27" @default.
• W1972565370 modified "2023-10-09" @default.
• W1972565370 title "Multihydroxylated [Gd@C₈₂(OH)₂₂]<i>_n</i> Nanoparticles: Antineoplastic Activity of High Efficiency and Low Toxicity" @default.
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• W1972565370 doi "https://doi.org/10.1021/nl051624b" @default.
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