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• W1972568275 abstract "A novel helper-free defective retrovirus containing the v-Ha-ras oncogene has been constructed and used to introduce the gene into primary mouse mammary epithelial cells already containing the v-myc oncogene. Transplantation of such doubly altered cells into cleared mammary fat pads led to the formation of mammary tumors within 6 to 8 weeks of transplantation. In a separate experiment, both oncogenes were simultaneously introduced to normal epithelium and once again tumours were formed. Neither oncogene alone gave a significant rate of tumour formation, although myc alone gave a reproducible hyperplasia as previously reported and ras alone gave occasional dysplastic or alveolar lesions. The results presented here demonstrate the progression of a normal cell through a hyperplastic intermediate to a tumour-forming cell in a versatile in vivo transplantation model." @default.
• W1972568275 created "2016-06-24" @default.
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• W1972568275 date "1991-07-30" @default.
• W1972568275 modified "2023-10-11" @default.
• W1972568275 title "Induction of mouse mammary tumours in a transplantation system by the sequential introduction of themyc andras oncogenes" @default.
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• W1972568275 doi "https://doi.org/10.1002/ijc.2910480619" @default.
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