Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972593274> ?p ?o ?g. }
- W1972593274 endingPage "1037" @default.
- W1972593274 startingPage "1029" @default.
- W1972593274 abstract "Antigenic stimulation through the B-cell antigen receptor (BCR) is considered to promote the expansion of chronic lymphocytic leukemia (CLL) B cells. The spleen tyrosine kinase (Syk), a key component of BCR signaling, can be blocked by R406, a small-molecule Syk inhibitor, that displayed activity in CLL patients in a first clinical trial. In this study, we investigated the effects of BCR stimulation and R406 on CLL cell survival and migration. The prosurvival effects promoted by anti-IgM stimulation and nurselike cells were abrogated by R406. BCR triggering up-regulated adhesion molecules, and increased CLL cell migration toward the chemokines CXCL12 and CXCL13. BCR activation also enhanced CLL cell migration beneath marrow stromal cells. These responses were blocked by R406, which furthermore abrogated BCR-dependent secretion of T-cell chemokines (CCL3 and CCL4) by CLL cells. Finally, R406 inhibited constitutive and BCR-induced activation of Syk, extracellular signal-regulated kinases, and AKT, and blocked BCR-induced calcium mobilization. These findings suggest that BCR activation favors CLL cell homing, retention, and survival in tissue microenvironments. R406 effectively blocks these BCR-dependent responses in CLL cells, providing an explanation for the activity of R406 in patients with CLL." @default.
- W1972593274 created "2016-06-24" @default.
- W1972593274 creator A5009968872 @default.
- W1972593274 creator A5024454882 @default.
- W1972593274 creator A5027575595 @default.
- W1972593274 creator A5053546109 @default.
- W1972593274 creator A5057732543 @default.
- W1972593274 creator A5058755419 @default.
- W1972593274 creator A5083315699 @default.
- W1972593274 creator A5089428686 @default.
- W1972593274 date "2009-07-30" @default.
- W1972593274 modified "2023-09-30" @default.
- W1972593274 title "B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, R406" @default.
- W1972593274 cites W115619992 @default.
- W1972593274 cites W1243376384 @default.
- W1972593274 cites W1429374962 @default.
- W1972593274 cites W1489024087 @default.
- W1972593274 cites W1492263161 @default.
- W1972593274 cites W1531083786 @default.
- W1972593274 cites W1964899672 @default.
- W1972593274 cites W1970663543 @default.
- W1972593274 cites W1971163722 @default.
- W1972593274 cites W1971436806 @default.
- W1972593274 cites W1976174817 @default.
- W1972593274 cites W1976767301 @default.
- W1972593274 cites W1979059478 @default.
- W1972593274 cites W1987402443 @default.
- W1972593274 cites W1987558041 @default.
- W1972593274 cites W1989593746 @default.
- W1972593274 cites W1990159135 @default.
- W1972593274 cites W1990986028 @default.
- W1972593274 cites W1993986769 @default.
- W1972593274 cites W2003363521 @default.
- W1972593274 cites W2004264801 @default.
- W1972593274 cites W2013050167 @default.
- W1972593274 cites W2033315156 @default.
- W1972593274 cites W2035916624 @default.
- W1972593274 cites W2036758696 @default.
- W1972593274 cites W2040500795 @default.
- W1972593274 cites W2040570751 @default.
- W1972593274 cites W2043139965 @default.
- W1972593274 cites W2043741078 @default.
- W1972593274 cites W2061249695 @default.
- W1972593274 cites W2066027952 @default.
- W1972593274 cites W2066539129 @default.
- W1972593274 cites W2067447878 @default.
- W1972593274 cites W2068868786 @default.
- W1972593274 cites W2070014828 @default.
- W1972593274 cites W2070953824 @default.
- W1972593274 cites W2076542620 @default.
- W1972593274 cites W2076690627 @default.
- W1972593274 cites W2087947799 @default.
- W1972593274 cites W2090358449 @default.
- W1972593274 cites W2091961397 @default.
- W1972593274 cites W2095726706 @default.
- W1972593274 cites W2097370957 @default.
- W1972593274 cites W2099348990 @default.
- W1972593274 cites W2107821023 @default.
- W1972593274 cites W2118164972 @default.
- W1972593274 cites W2131993766 @default.
- W1972593274 cites W2134139148 @default.
- W1972593274 cites W2140384293 @default.
- W1972593274 cites W2142978323 @default.
- W1972593274 cites W2143758178 @default.
- W1972593274 cites W2143790526 @default.
- W1972593274 cites W2149303991 @default.
- W1972593274 cites W2158509187 @default.
- W1972593274 cites W2158982717 @default.
- W1972593274 cites W2166526425 @default.
- W1972593274 cites W2172393633 @default.
- W1972593274 cites W2555823125 @default.
- W1972593274 cites W2563685161 @default.
- W1972593274 cites W34261213 @default.
- W1972593274 cites W76370582 @default.
- W1972593274 doi "https://doi.org/10.1182/blood-2009-03-212837" @default.
- W1972593274 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4916941" @default.
- W1972593274 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19491390" @default.
- W1972593274 hasPublicationYear "2009" @default.
- W1972593274 type Work @default.
- W1972593274 sameAs 1972593274 @default.
- W1972593274 citedByCount "219" @default.
- W1972593274 countsByYear W19725932742012 @default.
- W1972593274 countsByYear W19725932742013 @default.
- W1972593274 countsByYear W19725932742014 @default.
- W1972593274 countsByYear W19725932742015 @default.
- W1972593274 countsByYear W19725932742016 @default.
- W1972593274 countsByYear W19725932742017 @default.
- W1972593274 countsByYear W19725932742018 @default.
- W1972593274 countsByYear W19725932742019 @default.
- W1972593274 countsByYear W19725932742020 @default.
- W1972593274 countsByYear W19725932742021 @default.
- W1972593274 countsByYear W19725932742022 @default.
- W1972593274 countsByYear W19725932742023 @default.
- W1972593274 crossrefType "journal-article" @default.
- W1972593274 hasAuthorship W1972593274A5009968872 @default.
- W1972593274 hasAuthorship W1972593274A5024454882 @default.
- W1972593274 hasAuthorship W1972593274A5027575595 @default.
- W1972593274 hasAuthorship W1972593274A5053546109 @default.