FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972600527> ?p ?o ?g. }

• W1972600527 endingPage "62" @default.
• W1972600527 startingPage "55" @default.
• W1972600527 abstract "Cryptosporidium parvum is an intracellular protozoan parasite causing intestinal malabsorption and diarrhea in humans. The infection is usually self-limiting, although persistent cryptosporidosis is observed in immunocompromised and malnourished individuals. As with other Apicomplexa, the life cycle of Cryptosporidium is thought to comprise a sexual phase, during which a motile microgamont fuses with a sessile macrogamont. The four sporozoites found within each oocyst (the infectious form excreted in the feces) are thought to be the product of a meiotic division taking place immediately following fertilization, but the existence of a meiotic cycle in this genus has not been tested experimentally. To substantiate the occurrence of meiotic recombination in this species, we performed a genetic cross between two distinct isolates of C. parvum co-infected in INF-gamma knockout mice. We found that mixed infections produced recombinant progeny characterized by multilocus genotypes comprising alleles inherited from each parental line. This observation represents the first demonstration of sexual recombination in this pathogen. Together with the occurrence of genetically heterogeneous infections, this finding suggests that outcrossing between genotypes may occur in nature. Experimental crosses among Cryptosporidium populations will facilitate mapping of clinically relevant genes, the delineation of Cryptosporidium species, and defining the taxonomical status of C. parvum subtypes and host-specific genotypes." @default.
• W1972600527 created "2016-06-24" @default.
• W1972600527 creator A5010846884 @default.
• W1972600527 creator A5039421474 @default.
• W1972600527 creator A5061102263 @default.
• W1972600527 creator A5083825192 @default.
• W1972600527 date "2002-01-01" @default.
• W1972600527 modified "2023-10-15" @default.
• W1972600527 title "Experimental evidence for genetic recombination in the opportunistic pathogen Cryptosporidium parvum" @default.
• W1972600527 cites W1503822965 @default.
• W1972600527 cites W1778825775 @default.
• W1972600527 cites W1900762003 @default.
• W1972600527 cites W1930282251 @default.
• W1972600527 cites W1964729655 @default.
• W1972600527 cites W1979496167 @default.
• W1972600527 cites W1980752431 @default.
• W1972600527 cites W1986707605 @default.
• W1972600527 cites W2004593749 @default.
• W1972600527 cites W2020474278 @default.
• W1972600527 cites W2033653481 @default.
• W1972600527 cites W2035054548 @default.
• W1972600527 cites W2035079649 @default.
• W1972600527 cites W2070282290 @default.
• W1972600527 cites W2070514315 @default.
• W1972600527 cites W2089262366 @default.
• W1972600527 cites W2093236649 @default.
• W1972600527 cites W2096672760 @default.
• W1972600527 cites W2103059292 @default.
• W1972600527 cites W2115474893 @default.
• W1972600527 cites W2122899420 @default.
• W1972600527 cites W2129801755 @default.
• W1972600527 cites W2131667721 @default.
• W1972600527 cites W2135163002 @default.
• W1972600527 cites W2137304651 @default.
• W1972600527 cites W2146771667 @default.
• W1972600527 cites W2166367662 @default.
• W1972600527 cites W2171800021 @default.
• W1972600527 cites W2331163013 @default.
• W1972600527 cites W4236246518 @default.
• W1972600527 cites W4241170372 @default.
• W1972600527 cites W60879456 @default.
• W1972600527 doi "https://doi.org/10.1016/s0166-6851(01)00393-0" @default.
• W1972600527 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11755186" @default.
• W1972600527 hasPublicationYear "2002" @default.
• W1972600527 type Work @default.
• W1972600527 sameAs 1972600527 @default.
• W1972600527 citedByCount "62" @default.
• W1972600527 countsByYear W19726005272012 @default.
• W1972600527 countsByYear W19726005272013 @default.
• W1972600527 countsByYear W19726005272014 @default.
• W1972600527 countsByYear W19726005272015 @default.
• W1972600527 countsByYear W19726005272016 @default.
• W1972600527 countsByYear W19726005272017 @default.
• W1972600527 countsByYear W19726005272018 @default.
• W1972600527 countsByYear W19726005272019 @default.
• W1972600527 countsByYear W19726005272020 @default.
• W1972600527 countsByYear W19726005272021 @default.
• W1972600527 countsByYear W19726005272022 @default.
• W1972600527 countsByYear W19726005272023 @default.
• W1972600527 crossrefType "journal-article" @default.
• W1972600527 hasAuthorship W1972600527A5010846884 @default.
• W1972600527 hasAuthorship W1972600527A5039421474 @default.
• W1972600527 hasAuthorship W1972600527A5061102263 @default.
• W1972600527 hasAuthorship W1972600527A5083825192 @default.
• W1972600527 hasConcept C101434241 @default.
• W1972600527 hasConcept C102744134 @default.
• W1972600527 hasConcept C104317684 @default.
• W1972600527 hasConcept C135763542 @default.
• W1972600527 hasConcept C148196450 @default.
• W1972600527 hasConcept C156695909 @default.
• W1972600527 hasConcept C203014093 @default.
• W1972600527 hasConcept C2776460866 @default.
• W1972600527 hasConcept C2777795018 @default.
• W1972600527 hasConcept C2778048844 @default.
• W1972600527 hasConcept C2778371730 @default.
• W1972600527 hasConcept C2778877831 @default.
• W1972600527 hasConcept C2781023229 @default.
• W1972600527 hasConcept C54355233 @default.
• W1972600527 hasConcept C61716771 @default.
• W1972600527 hasConcept C86803240 @default.
• W1972600527 hasConcept C89423630 @default.
• W1972600527 hasConceptScore W1972600527C101434241 @default.
• W1972600527 hasConceptScore W1972600527C102744134 @default.
• W1972600527 hasConceptScore W1972600527C104317684 @default.
• W1972600527 hasConceptScore W1972600527C135763542 @default.
• W1972600527 hasConceptScore W1972600527C148196450 @default.
• W1972600527 hasConceptScore W1972600527C156695909 @default.
• W1972600527 hasConceptScore W1972600527C203014093 @default.
• W1972600527 hasConceptScore W1972600527C2776460866 @default.
• W1972600527 hasConceptScore W1972600527C2777795018 @default.
• W1972600527 hasConceptScore W1972600527C2778048844 @default.
• W1972600527 hasConceptScore W1972600527C2778371730 @default.
• W1972600527 hasConceptScore W1972600527C2778877831 @default.
• W1972600527 hasConceptScore W1972600527C2781023229 @default.
• W1972600527 hasConceptScore W1972600527C54355233 @default.
• W1972600527 hasConceptScore W1972600527C61716771 @default.
• W1972600527 hasConceptScore W1972600527C86803240 @default.
• W1972600527 hasConceptScore W1972600527C89423630 @default.

• next