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• W1972617786 abstract "Fast cyclic voltammetry (FCV) was used to measure electrically stimulated monoamine efflux in the rat ventral lateral geniculate nucleus (vLGN). The electrochemical characteristics of the released species resembled 5-HT but not dopamine or noradrenaline. Amine efflux was abolished by the sodium channel blocker tetrodotoxin (0.1 μM), Ro 4-1284 (1.0 μM), the fast-acting reserpine analogue, and removal of Ca2+ from the superfusate. Amine efflux was unaffected by the monoamine oxidase inhibitor clorgyline (0.1 μM). Of paroxetine (0.1 μM), desipramine (50 nM) and vanoxerine (0.5 μM), selective blockers of 5-HT, noradrenaline and dopamine uptake respectively, only paroxetine increased monoamine efflux (to 194±25%, mean±SEM) and prolonged the removal half-life (to 638±105%). The non-specific 5-HT1 antagonist methiothepin (0.2 μM) increased 5-HT efflux on long (20 pulses at 20 Hz) but not short trains (20 pulses at 100 Hz). When tested on pseudo-one-pulse stimulations (5 pulses, 100 Hz), the selective 5-HT1A agonist 8-OHDPAT (1.0 μM) had no effect. CP 93129 (0.3 μM), the selective 5-HT1B agonist, decreased 5-HT efflux to 37±4% of control and was antagonised by the 5-HT1B blocker isamoltane (0.5 μM) and by the 5-HT1D/B antagonist GR 127935 (50 nM). The preferential 5-HT1D agonist sumatriptan (0.5 μM) also decreased 5-HT efflux, to 55±6% and was antagonised by GR 127935 (50 nM) but not isamoltane (0.5 μM). These results suggest that 5-HT released in the vLGN can be measured by FCV. Furthermore, released 5-HT is taken up by the 5-HT transporter and may be under the influence of 5-HT1B and 5-HT1D autoreceptors." @default.
• W1972617786 created "2016-06-24" @default.
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• W1972617786 date "1996-01-01" @default.
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• W1972617786 title "Serotonin efflux in the rat ventral lateral geniculate nucleus assessed by fast cyclic voltammetry is modulated by 5-HT1B and 5-HT1D autoreceptors" @default.
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• W1972617786 doi "https://doi.org/10.1016/s0028-3908(96)00081-0" @default.
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