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- W1972624341 abstract "Insulin-like growth factor 1 receptor (IGF-1R) is a transmembrane receptor tyrosine kinase involved in the development and progression of cancer whose activation strongly promotes cell growth and survival. IGF-1R exerts its main actions through the activation of the mitogen-activated protein kinase and phosphoinositide 3-kinase pathways. In addition to their traditional roles, IGF-1R activation has been associated with increased radioresistance both in vitro and in vivo, although the molecular mechanisms behind this process are still unclear. Recently, IGF-1R has been associated to new partners as major vault proteins, BCL-2, BAX, or Ku70/80, related to radiochemotherapy resistance, regulation of apoptosis, and nonhomologous end-joining DNA repair. Here, we review these novel associations of IGF-1R trying to explain the resistance to radiotherapy mediated by IGF-1R. Finally, we revised the role of new therapies leading to block the receptor to enhance the efficacy of radiation." @default.
- W1972624341 created "2016-06-24" @default.
- W1972624341 creator A5002657236 @default.
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- W1972624341 creator A5078392631 @default.
- W1972624341 date "2012-02-01" @default.
- W1972624341 modified "2023-10-18" @default.
- W1972624341 title "Role of IGF-1 Receptor in Radiation Response" @default.
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- W1972624341 doi "https://doi.org/10.1593/tlo.11265" @default.
- W1972624341 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3281411" @default.
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- W1972624341 hasPublicationYear "2012" @default.
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