FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972629202> ?p ?o ?g. }

• W1972629202 endingPage "2599" @default.
• W1972629202 startingPage "2588" @default.
• W1972629202 abstract "Lead compounds exhibit a high degree of cytotoxicity and carcinogenicity. We evaluated the impact of lead acetate on the liver by skin exposure as well as the changes in protein profiles reflecting pathogenic processes. Functional proteomic tools showed that the most meaningful protein changes were involved in protein folding, ER stress, and apoptosis in the presence of an organic lead compound. Treatment with lead acetate also elicits intracellular ROS levels as well as carbonyl modification of chaperone proteins, suggesting that lead might trigger the unfolded protein response due to oxidative stress. Lead application induced ER stress, as indicated by the promotion of GRP78 and by increased expression of the transcription factors ATF6, IRE1α, and PERK. Moreover, upregulation of GRP75 may participate in lead-caused hepatic cytotoxicity while abrogation of GRP75 appears to attenuate the inhibition of cell growth. Our findings demonstrate that accumulation of organic lead in the liver can induce oxidative imbalance and protein impairment that may result in ER stress followed by liver injuries. Hepatic proteome profiles delineate a finer picture of protein networks and metabolic pathways primarily involved in lead-initiated hepatic toxicity via skin exposure." @default.
• W1972629202 created "2016-06-24" @default.
• W1972629202 creator A5005101214 @default.
• W1972629202 creator A5016720326 @default.
• W1972629202 creator A5022040282 @default.
• W1972629202 creator A5025830476 @default.
• W1972629202 creator A5034275684 @default.
• W1972629202 date "2014-10-21" @default.
• W1972629202 modified "2023-09-23" @default.
• W1972629202 title "Evaluation of the hepatotoxic risk caused by lead acetate via skin exposure using a proteomic approach" @default.
• W1972629202 cites W1923785651 @default.
• W1972629202 cites W1964770927 @default.
• W1972629202 cites W1966521314 @default.
• W1972629202 cites W1967382195 @default.
• W1972629202 cites W1968739470 @default.
• W1972629202 cites W1981438169 @default.
• W1972629202 cites W1981930915 @default.
• W1972629202 cites W1982584501 @default.
• W1972629202 cites W1991825280 @default.
• W1972629202 cites W1995182877 @default.
• W1972629202 cites W1999030622 @default.
• W1972629202 cites W2001259429 @default.
• W1972629202 cites W2001731652 @default.
• W1972629202 cites W2003604425 @default.
• W1972629202 cites W2008453452 @default.
• W1972629202 cites W2011735999 @default.
• W1972629202 cites W2018014346 @default.
• W1972629202 cites W2018404966 @default.
• W1972629202 cites W2022717812 @default.
• W1972629202 cites W2033900483 @default.
• W1972629202 cites W2050935157 @default.
• W1972629202 cites W2058706780 @default.
• W1972629202 cites W2059349976 @default.
• W1972629202 cites W2059586093 @default.
• W1972629202 cites W2059952390 @default.
• W1972629202 cites W2067240761 @default.
• W1972629202 cites W2068073585 @default.
• W1972629202 cites W2079149444 @default.
• W1972629202 cites W2080378383 @default.
• W1972629202 cites W2086561195 @default.
• W1972629202 cites W2087516011 @default.
• W1972629202 cites W2121836743 @default.
• W1972629202 cites W2129775789 @default.
• W1972629202 cites W2135213880 @default.
• W1972629202 cites W2136776712 @default.
• W1972629202 cites W2138992670 @default.
• W1972629202 cites W2141456619 @default.
• W1972629202 cites W2142795496 @default.
• W1972629202 cites W2164609484 @default.
• W1972629202 doi "https://doi.org/10.1002/pmic.201400068" @default.
• W1972629202 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25210813" @default.
• W1972629202 hasPublicationYear "2014" @default.
• W1972629202 type Work @default.
• W1972629202 sameAs 1972629202 @default.
• W1972629202 citedByCount "13" @default.
• W1972629202 countsByYear W19726292022015 @default.
• W1972629202 countsByYear W19726292022016 @default.
• W1972629202 countsByYear W19726292022017 @default.
• W1972629202 countsByYear W19726292022018 @default.
• W1972629202 countsByYear W19726292022019 @default.
• W1972629202 countsByYear W19726292022020 @default.
• W1972629202 countsByYear W19726292022021 @default.
• W1972629202 crossrefType "journal-article" @default.
• W1972629202 hasAuthorship W1972629202A5005101214 @default.
• W1972629202 hasAuthorship W1972629202A5016720326 @default.
• W1972629202 hasAuthorship W1972629202A5022040282 @default.
• W1972629202 hasAuthorship W1972629202A5025830476 @default.
• W1972629202 hasAuthorship W1972629202A5034275684 @default.
• W1972629202 hasConcept C104317684 @default.
• W1972629202 hasConcept C104397665 @default.
• W1972629202 hasConcept C109316439 @default.
• W1972629202 hasConcept C127561419 @default.
• W1972629202 hasConcept C139447449 @default.
• W1972629202 hasConcept C158617107 @default.
• W1972629202 hasConcept C178790620 @default.
• W1972629202 hasConcept C185592680 @default.
• W1972629202 hasConcept C190283241 @default.
• W1972629202 hasConcept C202751555 @default.
• W1972629202 hasConcept C2776151105 @default.
• W1972629202 hasConcept C2778997996 @default.
• W1972629202 hasConcept C2779224224 @default.
• W1972629202 hasConcept C29730261 @default.
• W1972629202 hasConcept C55493867 @default.
• W1972629202 hasConcept C79879829 @default.
• W1972629202 hasConcept C86803240 @default.
• W1972629202 hasConcept C95444343 @default.
• W1972629202 hasConceptScore W1972629202C104317684 @default.
• W1972629202 hasConceptScore W1972629202C104397665 @default.
• W1972629202 hasConceptScore W1972629202C109316439 @default.
• W1972629202 hasConceptScore W1972629202C127561419 @default.
• W1972629202 hasConceptScore W1972629202C139447449 @default.
• W1972629202 hasConceptScore W1972629202C158617107 @default.
• W1972629202 hasConceptScore W1972629202C178790620 @default.
• W1972629202 hasConceptScore W1972629202C185592680 @default.
• W1972629202 hasConceptScore W1972629202C190283241 @default.
• W1972629202 hasConceptScore W1972629202C202751555 @default.
• W1972629202 hasConceptScore W1972629202C2776151105 @default.
• W1972629202 hasConceptScore W1972629202C2778997996 @default.

• next