Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972638997> ?p ?o ?g. }
- W1972638997 endingPage "e17483" @default.
- W1972638997 startingPage "e17483" @default.
- W1972638997 abstract "It is well acknowledged from observations in humans that iron deficiency during pregnancy can be associated with a number of developmental problems in the newborn and developing child. Due to the obvious limitations of human studies, the stage during gestation at which maternal iron deficiency causes an apparent impairment in the offspring remains elusive. In order to begin to understand the time window(s) during pregnancy that is/are especially susceptible to suboptimal iron levels, which may result in negative effects on the development of the fetus, we developed a rat model in which we were able to manipulate and monitor the dietary iron intake during specific stages of pregnancy and analyzed the developing fetuses. We established four different dietary-feeding protocols that were designed to render the fetuses iron deficient at different gestational stages. Based on a functional analysis that employed Auditory Brainstem Response measurements, we found that maternal iron restriction initiated prior to conception and during the first trimester were associated with profound changes in the developing fetus compared to iron restriction initiated later in pregnancy. We also showed that the presence of iron deficiency anemia, low body weight, and changes in core body temperature were not defining factors in the establishment of neural impairment in the rodent offspring.Our data may have significant relevance for understanding the impact of suboptimal iron levels during pregnancy not only on the mother but also on the developing fetus and hence might lead to a more informed timing of iron supplementation during pregnancy." @default.
- W1972638997 created "2016-06-24" @default.
- W1972638997 creator A5016893297 @default.
- W1972638997 creator A5037535687 @default.
- W1972638997 creator A5045811158 @default.
- W1972638997 creator A5046708795 @default.
- W1972638997 creator A5049766834 @default.
- W1972638997 creator A5062293003 @default.
- W1972638997 creator A5085038387 @default.
- W1972638997 date "2011-03-15" @default.
- W1972638997 modified "2023-10-01" @default.
- W1972638997 title "Identifying a Window of Vulnerability during Fetal Development in a Maternal Iron Restriction Model" @default.
- W1972638997 cites W1486025779 @default.
- W1972638997 cites W1547233342 @default.
- W1972638997 cites W1780031418 @default.
- W1972638997 cites W1897061261 @default.
- W1972638997 cites W1903173503 @default.
- W1972638997 cites W1931479270 @default.
- W1972638997 cites W1945987068 @default.
- W1972638997 cites W1951863625 @default.
- W1972638997 cites W1961040664 @default.
- W1972638997 cites W1965250226 @default.
- W1972638997 cites W1965575986 @default.
- W1972638997 cites W1966539245 @default.
- W1972638997 cites W1966549062 @default.
- W1972638997 cites W1968022727 @default.
- W1972638997 cites W1976364521 @default.
- W1972638997 cites W1979917165 @default.
- W1972638997 cites W1980882008 @default.
- W1972638997 cites W1982147309 @default.
- W1972638997 cites W1983268706 @default.
- W1972638997 cites W1984845481 @default.
- W1972638997 cites W1989633554 @default.
- W1972638997 cites W1993086223 @default.
- W1972638997 cites W1994986370 @default.
- W1972638997 cites W1997748912 @default.
- W1972638997 cites W1998083685 @default.
- W1972638997 cites W1998863402 @default.
- W1972638997 cites W1998891136 @default.
- W1972638997 cites W2003530379 @default.
- W1972638997 cites W2005535963 @default.
- W1972638997 cites W2007341928 @default.
- W1972638997 cites W2007670277 @default.
- W1972638997 cites W2014684895 @default.
- W1972638997 cites W2016731476 @default.
- W1972638997 cites W2018495539 @default.
- W1972638997 cites W2021315518 @default.
- W1972638997 cites W2023199566 @default.
- W1972638997 cites W2030956785 @default.
- W1972638997 cites W2033301706 @default.
- W1972638997 cites W2034630699 @default.
- W1972638997 cites W2034759459 @default.
- W1972638997 cites W2035058309 @default.
- W1972638997 cites W2035124006 @default.
- W1972638997 cites W2039269520 @default.
- W1972638997 cites W2042040204 @default.
- W1972638997 cites W2051275859 @default.
- W1972638997 cites W2064612203 @default.
- W1972638997 cites W2065329445 @default.
- W1972638997 cites W2069382797 @default.
- W1972638997 cites W2070592454 @default.
- W1972638997 cites W2073557360 @default.
- W1972638997 cites W2076922706 @default.
- W1972638997 cites W2078085048 @default.
- W1972638997 cites W2080534262 @default.
- W1972638997 cites W2086082591 @default.
- W1972638997 cites W2086621773 @default.
- W1972638997 cites W2088469352 @default.
- W1972638997 cites W2088987050 @default.
- W1972638997 cites W2089479951 @default.
- W1972638997 cites W2091672223 @default.
- W1972638997 cites W2093068417 @default.
- W1972638997 cites W2096249966 @default.
- W1972638997 cites W2096438171 @default.
- W1972638997 cites W2100112473 @default.
- W1972638997 cites W2101347270 @default.
- W1972638997 cites W2101767156 @default.
- W1972638997 cites W2101791099 @default.
- W1972638997 cites W2105594557 @default.
- W1972638997 cites W2107280662 @default.
- W1972638997 cites W2116909901 @default.
- W1972638997 cites W2118722138 @default.
- W1972638997 cites W2123648055 @default.
- W1972638997 cites W2124539304 @default.
- W1972638997 cites W2131386802 @default.
- W1972638997 cites W2131814649 @default.
- W1972638997 cites W2132087610 @default.
- W1972638997 cites W2134451945 @default.
- W1972638997 cites W2134462026 @default.
- W1972638997 cites W2136459252 @default.
- W1972638997 cites W2142321401 @default.
- W1972638997 cites W2148012914 @default.
- W1972638997 cites W2148948489 @default.
- W1972638997 cites W2151068858 @default.
- W1972638997 cites W2155005455 @default.
- W1972638997 cites W2159297940 @default.
- W1972638997 cites W2162527851 @default.
- W1972638997 cites W2168799144 @default.