Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972644823> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W1972644823 endingPage "155" @default.
- W1972644823 startingPage "155" @default.
- W1972644823 abstract "Hypermethylation of tumor-suppressor genes has been implicated in the pathogenesis of human cancers. This study was designed to examine the methylation profiles of a selected group of p53 target genes (APAF-1, CASP-8, DAPK-1, IGFBP-3) and to correlate the findings with the histopathological characterization of testicular germ cell tumors (TGCT).Promoter methylation status was analysed by highly sensitive real-time methylation-specific PCR in 46 primary TGCTs (26 seminomas and 20 nonseminomas) and 15 normal testicular tissue samples. APAF-1 methylation was detected in all of the seminomatous and nonseminomatous TGCTs as well as in 60% of normal testicular tissue. Methylation of DAPK-1 was frequent in seminomas (50%) and nonseminomas (20%), but not in normal testicular tissue (6%). The degree of DAPK-1 methylation correlated with the clinical stage of the disease (P=0.05) and was useful in differentiating seminomatous from nonseminomatous, and malignant from nonmalignant testicular tissue (P=0.04 and 0.02, respectively). The APAF-1 methylation index achieved a highly significant differentiation between seminomatous or nonseminomatous tissue and nonmalignant testicular tissue (P=0.0001). In testicular tumorigenesis, promoter methylation of specific p53 target genes occurs at early stage but to varying degrees. Methylation also occurs in normal testicular tissue, which is in contrast to findings in other urogenital malignancies. Further studies will be necessary to determine whether the methylation level may be used as marker for risk estimation, especially in clinical stage I disease." @default.
- W1972644823 created "2016-06-24" @default.
- W1972644823 creator A5006106305 @default.
- W1972644823 creator A5012476826 @default.
- W1972644823 creator A5013239910 @default.
- W1972644823 creator A5017015998 @default.
- W1972644823 creator A5048386880 @default.
- W1972644823 creator A5075627853 @default.
- W1972644823 creator A5076852126 @default.
- W1972644823 creator A5079462263 @default.
- W1972644823 creator A5083327004 @default.
- W1972644823 date "2007-03-01" @default.
- W1972644823 modified "2023-09-23" @default.
- W1972644823 title "531 THE EQUILIBRIUM OF XIAP AND SMAC/DIABLO IS GRADUALLY DERANGED DURING THE DEVELOPMENT AND PROGRESSION OF TESTICULAR GERM CELL TUMORS" @default.
- W1972644823 doi "https://doi.org/10.1016/s1569-9056(07)60529-6" @default.
- W1972644823 hasPublicationYear "2007" @default.
- W1972644823 type Work @default.
- W1972644823 sameAs 1972644823 @default.
- W1972644823 citedByCount "0" @default.
- W1972644823 crossrefType "journal-article" @default.
- W1972644823 hasAuthorship W1972644823A5006106305 @default.
- W1972644823 hasAuthorship W1972644823A5012476826 @default.
- W1972644823 hasAuthorship W1972644823A5013239910 @default.
- W1972644823 hasAuthorship W1972644823A5017015998 @default.
- W1972644823 hasAuthorship W1972644823A5048386880 @default.
- W1972644823 hasAuthorship W1972644823A5075627853 @default.
- W1972644823 hasAuthorship W1972644823A5076852126 @default.
- W1972644823 hasAuthorship W1972644823A5079462263 @default.
- W1972644823 hasAuthorship W1972644823A5083327004 @default.
- W1972644823 hasConcept C104317684 @default.
- W1972644823 hasConcept C121608353 @default.
- W1972644823 hasConcept C126322002 @default.
- W1972644823 hasConcept C142724271 @default.
- W1972644823 hasConcept C146357865 @default.
- W1972644823 hasConcept C150194340 @default.
- W1972644823 hasConcept C151730666 @default.
- W1972644823 hasConcept C16685009 @default.
- W1972644823 hasConcept C190727270 @default.
- W1972644823 hasConcept C2776212926 @default.
- W1972644823 hasConcept C2776694085 @default.
- W1972644823 hasConcept C2778074268 @default.
- W1972644823 hasConcept C2911180711 @default.
- W1972644823 hasConcept C33288867 @default.
- W1972644823 hasConcept C41091548 @default.
- W1972644823 hasConcept C502942594 @default.
- W1972644823 hasConcept C54355233 @default.
- W1972644823 hasConcept C555283112 @default.
- W1972644823 hasConcept C71924100 @default.
- W1972644823 hasConcept C86803240 @default.
- W1972644823 hasConceptScore W1972644823C104317684 @default.
- W1972644823 hasConceptScore W1972644823C121608353 @default.
- W1972644823 hasConceptScore W1972644823C126322002 @default.
- W1972644823 hasConceptScore W1972644823C142724271 @default.
- W1972644823 hasConceptScore W1972644823C146357865 @default.
- W1972644823 hasConceptScore W1972644823C150194340 @default.
- W1972644823 hasConceptScore W1972644823C151730666 @default.
- W1972644823 hasConceptScore W1972644823C16685009 @default.
- W1972644823 hasConceptScore W1972644823C190727270 @default.
- W1972644823 hasConceptScore W1972644823C2776212926 @default.
- W1972644823 hasConceptScore W1972644823C2776694085 @default.
- W1972644823 hasConceptScore W1972644823C2778074268 @default.
- W1972644823 hasConceptScore W1972644823C2911180711 @default.
- W1972644823 hasConceptScore W1972644823C33288867 @default.
- W1972644823 hasConceptScore W1972644823C41091548 @default.
- W1972644823 hasConceptScore W1972644823C502942594 @default.
- W1972644823 hasConceptScore W1972644823C54355233 @default.
- W1972644823 hasConceptScore W1972644823C555283112 @default.
- W1972644823 hasConceptScore W1972644823C71924100 @default.
- W1972644823 hasConceptScore W1972644823C86803240 @default.
- W1972644823 hasIssue "2" @default.
- W1972644823 hasLocation W19726448231 @default.
- W1972644823 hasOpenAccess W1972644823 @default.
- W1972644823 hasPrimaryLocation W19726448231 @default.
- W1972644823 hasRelatedWork W2157069906 @default.
- W1972644823 hasRelatedWork W2167145211 @default.
- W1972644823 hasRelatedWork W2304569214 @default.
- W1972644823 hasRelatedWork W2364742912 @default.
- W1972644823 hasRelatedWork W2414449891 @default.
- W1972644823 hasRelatedWork W2419052824 @default.
- W1972644823 hasRelatedWork W2588398605 @default.
- W1972644823 hasRelatedWork W2745115887 @default.
- W1972644823 hasRelatedWork W3210274727 @default.
- W1972644823 hasRelatedWork W4205403772 @default.
- W1972644823 hasVolume "6" @default.
- W1972644823 isParatext "false" @default.
- W1972644823 isRetracted "false" @default.
- W1972644823 magId "1972644823" @default.
- W1972644823 workType "article" @default.