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• W1972646164 abstract "It is generally accepted that activation of voltage sensors in the T-tubular membranes is a critical step of excitation-contraction coupling in skeletal muscle. The purpose of this study was to evaluate further whether the Qgamma component (delayed 'hump' component) of the intramembranous charge movement current (I(cm)) results from movement of these voltage sensors. Ca2+ release and I(cm) were measured in voltage-clamped frog cut fibres mounted in a double Vaseline-gap chamber. In order to reduce effects of Ca2+ feedback mechanisms, the calcium content of the sarcoplasmic reticulum (SR) during rest was reduced to < 250 microM (referred to volume of myoplasm) and maintained approximately constant. The early (Qbeta) and Qgamma components of charge movement were estimated by fitting the sum of two Boltzmann functions to the total steady-state intramembranous charge vs. voltage data. The average voltage steepness factor (k) and half-maximal voltage (V-) for Qgamma were 4.3 and -57.4 mV (n = 6), respectively. The SR membrane permeability for Ca2+ release was assessed when a constant amount of calcium remained in the SR (usually about 60 microM). A single Boltzmann function fitted to these data gave values on average for k and V- of 4.7 and -45.3 mV, respectively. The similarity of the values of k for Qgamma and Ca2+ release supports the idea that Qgamma reflects movement of voltage sensors for Ca2+ release. The greater value of V- for Ca2+ release compared to Qgamma is consistent with multi-state models of the voltage sensor involving movement of Qgamma charge during non-activating transitions." @default.
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• W1972646164 date "2002-02-01" @default.
• W1972646164 modified "2023-10-18" @default.
• W1972646164 title "Calcium release and intramembranous charge movement in frog skeletal muscle fibres with reduced (< 250 μM) calcium content" @default.
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• W1972646164 doi "https://doi.org/10.1113/jphysiol.2001.012728" @default.
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