FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972649215> ?p ?o ?g. }

• W1972649215 endingPage "375" @default.
• W1972649215 startingPage "345" @default.
• W1972649215 abstract "Human data were searched to determine whether an association of metabolically or drug-induced maternal toxicity with congenital malformations and intrauterine death would be valid for the human species. Intrauterine death was found to occur in association with maternal homeostatic alterations resulting from phenylketonuria and diabetes, and with maternal toxicity from toxemia of pregnancy, leukemia, burns, alcohol, aminopterin, isotretinoin, and possibly trimethadione. A pattern of anomalies found similar (except for minor differences) and thus suggestive of a possible common cause, was observed among anomalies to phenylketonuria, diabetes mellitus, aminopterin, alcohol, warfarin, phenytoin, phenobarbital, trimethadione, valproic acid, and isotretinoin. The pattern usually consisted of deficiencies in pre- and postnatal development, mid-facial hypoplasia, cleft palate, atrial or ventricular septal defects, patent ductus arteriosus, hypospadias, hernias, and other less frequent anomalies. The pattern is tentatively associated with alterations in maternal physiology resulting from phenylketonuria and diabetes; maternal toxicity of aminopterin, alcohol, and diverse factors co-occurring with warfarin use; and therapeutic doses (generally toxic in adults) of phenytoin, phenobarbital, trimethadione, and valproic acid. Whether these fetal malformations and intrauterine deaths would occur at nonmaterno-toxic levels of the above teratogenic agents, and, consequently, the strength of the associations could not be estimated for lack of data. However, human data seem to provide some, though weak, support and not to contradict the previous assumption formulated from animal studies that maternal toxicity may be causally related to fetal malformations and embryo-fetal mortality." @default.
• W1972649215 created "2016-06-24" @default.
• W1972649215 creator A5030220416 @default.
• W1972649215 creator A5065184969 @default.
• W1972649215 date "1987-01-01" @default.
• W1972649215 modified "2023-10-14" @default.
• W1972649215 title "Maternal Toxicity of Drugs and Metabolic Disorders—A Possible Etiologic Factor in the Intrauterine Death and Congenital Malformation: A Critique on Human Data" @default.
• W1972649215 cites W121586751 @default.
• W1972649215 cites W1475762121 @default.
• W1972649215 cites W1483643622 @default.
• W1972649215 cites W1501114398 @default.
• W1972649215 cites W1544729098 @default.
• W1972649215 cites W1545686983 @default.
• W1972649215 cites W1564240897 @default.
• W1972649215 cites W1566582855 @default.
• W1972649215 cites W1572938782 @default.
• W1972649215 cites W1575907934 @default.
• W1972649215 cites W1580600892 @default.
• W1972649215 cites W1650844427 @default.
• W1972649215 cites W1697684369 @default.
• W1972649215 cites W1840860681 @default.
• W1972649215 cites W1868848109 @default.
• W1972649215 cites W1886391002 @default.
• W1972649215 cites W1912380029 @default.
• W1972649215 cites W1965087559 @default.
• W1972649215 cites W1965965368 @default.
• W1972649215 cites W1967025529 @default.
• W1972649215 cites W1970390304 @default.
• W1972649215 cites W1971939038 @default.
• W1972649215 cites W1975422380 @default.
• W1972649215 cites W1977228369 @default.
• W1972649215 cites W1978173138 @default.
• W1972649215 cites W1985479666 @default.
• W1972649215 cites W1988892144 @default.
• W1972649215 cites W1989146372 @default.
• W1972649215 cites W1999982652 @default.
• W1972649215 cites W2001468330 @default.
• W1972649215 cites W2001491327 @default.
• W1972649215 cites W2002055592 @default.
• W1972649215 cites W2002922732 @default.
• W1972649215 cites W2004284326 @default.
• W1972649215 cites W2005232998 @default.
• W1972649215 cites W2005290017 @default.
• W1972649215 cites W2007858816 @default.
• W1972649215 cites W2008211763 @default.
• W1972649215 cites W2010235639 @default.
• W1972649215 cites W2010352809 @default.
• W1972649215 cites W2014377627 @default.
• W1972649215 cites W2014854253 @default.
• W1972649215 cites W2014934119 @default.
• W1972649215 cites W2015824214 @default.
• W1972649215 cites W2019419498 @default.
• W1972649215 cites W2020137563 @default.
• W1972649215 cites W2023807978 @default.
• W1972649215 cites W2033028106 @default.
• W1972649215 cites W2035313599 @default.
• W1972649215 cites W2036064499 @default.
• W1972649215 cites W2039186333 @default.
• W1972649215 cites W2040728381 @default.
• W1972649215 cites W2042534617 @default.
• W1972649215 cites W2042842841 @default.
• W1972649215 cites W2043073344 @default.
• W1972649215 cites W2043110199 @default.
• W1972649215 cites W2043729346 @default.
• W1972649215 cites W2044057700 @default.
• W1972649215 cites W2044088991 @default.
• W1972649215 cites W2045327684 @default.
• W1972649215 cites W2050638741 @default.
• W1972649215 cites W2052101296 @default.
• W1972649215 cites W2053744213 @default.
• W1972649215 cites W2057414645 @default.
• W1972649215 cites W2060227584 @default.
• W1972649215 cites W2062403124 @default.
• W1972649215 cites W2065594609 @default.
• W1972649215 cites W2069063448 @default.
• W1972649215 cites W2069091414 @default.
• W1972649215 cites W2071591879 @default.
• W1972649215 cites W2074001949 @default.
• W1972649215 cites W2077852530 @default.
• W1972649215 cites W2082359575 @default.
• W1972649215 cites W2087583319 @default.
• W1972649215 cites W2088210995 @default.
• W1972649215 cites W2090814473 @default.
• W1972649215 cites W2091517837 @default.
• W1972649215 cites W2093021774 @default.
• W1972649215 cites W2093568993 @default.
• W1972649215 cites W2095218503 @default.
• W1972649215 cites W2099368520 @default.
• W1972649215 cites W2102848435 @default.
• W1972649215 cites W2104692465 @default.
• W1972649215 cites W2105962679 @default.
• W1972649215 cites W2119055048 @default.
• W1972649215 cites W2125629208 @default.
• W1972649215 cites W2132576272 @default.
• W1972649215 cites W2154000410 @default.
• W1972649215 cites W2167199949 @default.
• W1972649215 cites W2182943622 @default.
• W1972649215 cites W2184335511 @default.

• next