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• W1972654719 startingPage "9150" @default.
• W1972654719 abstract "Coordination between separate pathways may be facilitated by the requirements for common protein factors, a finding congruent with the link between proteins regulating DNA replication with other important cellular processes. We report that the smallest of Drosophila origin recognition complex subunits, Orc6, was found in embryos and cell culture localized to the cell membrane and cleavage furrow during cell division as well as in the nucleus. A two-hybrid screen revealed that Orc6 interacts with the Drosophila peanut (pnut), a member of the septin family of proteins important for cell division. This interaction, mediated by a distinct C-terminal domain of Orc6, was substantiated in Drosophila cells by coimmunoprecipitation from extracts and cytological methods. Silencing of Orc6 expression with double-stranded RNA resulted in a formation of multinucleated cells and also reduced DNA replication. Deletion of the C-terminal Orc6-peanut interaction domain and subsequent overexpression of the Orc6 mutant protein resulted in the formation of multinucleated cells that had replicated DNA. This mutant protein does not localize to the membrane or cleavage furrows. These results suggest that Orc6 has evolved a domain critical mainly for cytokinesis." @default.
• W1972654719 created "2016-06-24" @default.
• W1972654719 creator A5019636239 @default.
• W1972654719 creator A5056295815 @default.
• W1972654719 creator A5072265713 @default.
• W1972654719 date "2003-07-23" @default.
• W1972654719 modified "2023-09-26" @default.
• W1972654719 title "A cytokinetic function of <i>Drosophila</i> ORC6 protein resides in a domain distinct from its replication activity" @default.
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• W1972654719 doi "https://doi.org/10.1073/pnas.1633580100" @default.
• W1972654719 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/170887" @default.
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• W1972654719 hasPublicationYear "2003" @default.
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