FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972661330> ?p ?o ?g. }

• W1972661330 endingPage "310" @default.
• W1972661330 startingPage "303" @default.
• W1972661330 abstract "1. The interactions between herbal dietary supplements and therapeutic drugs have emerged as an important issue and P-glycoprotein (P-gp) has been reported as one of the significant factors of these interactions. 2. The objective of this article is to examine the effects of single and repeated administrations of silymarin on pharmacokinetics of a P-gp substrate, risperidone, and its major metabolite, 9-hydroxyrisperidone, in rats. 3. To determine the plasma levels of risperidone and 9-hydroxyrisperidone in rats, a HPLC method was developed using a liquid-liquid acid back extraction. When risperidone (6 mg/kg) was co-administered with silymarin (40 mg/kg) to rats orally, the C(max) of 9-hydroxyrisperidone was significantly increased to1.3-fold (p < 0.05), while the other pharmacokinetic parameters did not show any significant differences. Expanding the experiment where rats were repeatedly administered with silymarin for 5 days prior to giving risperidone, the C(max) of risperidone and 9-hydroxyrisperidone were significantly increased to 2.4-fold (p < 0.001) and 1.7-fold (p < 0.001), respectively, and the AUC(0-t), as well to 1.7-fold (p < 0.05) and 2.1-fold (p < 0.01), respectively. 4. The repeated exposures of silymarin, compared to single administration of silymarin, increased oral bioavailability and affected the pharmacokinetics of risperidone and 9-hydroxyrisperidone, by inhibiting P-gp." @default.
• W1972661330 created "2016-06-24" @default.
• W1972661330 creator A5004277197 @default.
• W1972661330 creator A5013532359 @default.
• W1972661330 creator A5025153310 @default.
• W1972661330 creator A5030102087 @default.
• W1972661330 creator A5047445678 @default.
• W1972661330 creator A5050730588 @default.
• W1972661330 creator A5075893557 @default.
• W1972661330 date "2012-12-04" @default.
• W1972661330 modified "2023-09-25" @default.
• W1972661330 title "Effects of single or repeated silymarin administration on pharmacokinetics of risperidone and its major metabolite, 9-hydroxyrisperidone in rats" @default.
• W1972661330 cites W1505525797 @default.
• W1972661330 cites W171460375 @default.
• W1972661330 cites W1969738024 @default.
• W1972661330 cites W1982708063 @default.
• W1972661330 cites W2017577682 @default.
• W1972661330 cites W2020245539 @default.
• W1972661330 cites W2025663121 @default.
• W1972661330 cites W2029684586 @default.
• W1972661330 cites W2034400329 @default.
• W1972661330 cites W2036657821 @default.
• W1972661330 cites W2036889312 @default.
• W1972661330 cites W2053545020 @default.
• W1972661330 cites W2058726694 @default.
• W1972661330 cites W2058928933 @default.
• W1972661330 cites W2063528348 @default.
• W1972661330 cites W2065817940 @default.
• W1972661330 cites W2068442128 @default.
• W1972661330 cites W2070829073 @default.
• W1972661330 cites W2076778120 @default.
• W1972661330 cites W2080185803 @default.
• W1972661330 cites W2090632754 @default.
• W1972661330 cites W2092118786 @default.
• W1972661330 cites W2100780314 @default.
• W1972661330 cites W2100966423 @default.
• W1972661330 cites W2104806386 @default.
• W1972661330 cites W2114098531 @default.
• W1972661330 cites W2124465755 @default.
• W1972661330 cites W2127645257 @default.
• W1972661330 cites W2132806259 @default.
• W1972661330 cites W2151680183 @default.
• W1972661330 cites W2154105843 @default.
• W1972661330 cites W2159398836 @default.
• W1972661330 cites W2168807338 @default.
• W1972661330 doi "https://doi.org/10.3109/00498254.2012.731092" @default.
• W1972661330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23205514" @default.
• W1972661330 hasPublicationYear "2012" @default.
• W1972661330 type Work @default.
• W1972661330 sameAs 1972661330 @default.
• W1972661330 citedByCount "9" @default.
• W1972661330 countsByYear W19726613302013 @default.
• W1972661330 countsByYear W19726613302017 @default.
• W1972661330 countsByYear W19726613302019 @default.
• W1972661330 countsByYear W19726613302021 @default.
• W1972661330 countsByYear W19726613302023 @default.
• W1972661330 crossrefType "journal-article" @default.
• W1972661330 hasAuthorship W1972661330A5004277197 @default.
• W1972661330 hasAuthorship W1972661330A5013532359 @default.
• W1972661330 hasAuthorship W1972661330A5025153310 @default.
• W1972661330 hasAuthorship W1972661330A5030102087 @default.
• W1972661330 hasAuthorship W1972661330A5047445678 @default.
• W1972661330 hasAuthorship W1972661330A5050730588 @default.
• W1972661330 hasAuthorship W1972661330A5075893557 @default.
• W1972661330 hasConcept C112705442 @default.
• W1972661330 hasConcept C118552586 @default.
• W1972661330 hasConcept C126322002 @default.
• W1972661330 hasConcept C149151106 @default.
• W1972661330 hasConcept C181389837 @default.
• W1972661330 hasConcept C185592680 @default.
• W1972661330 hasConcept C2776412080 @default.
• W1972661330 hasConcept C2777056448 @default.
• W1972661330 hasConcept C2777477808 @default.
• W1972661330 hasConcept C2780057945 @default.
• W1972661330 hasConcept C71924100 @default.
• W1972661330 hasConcept C98274493 @default.
• W1972661330 hasConceptScore W1972661330C112705442 @default.
• W1972661330 hasConceptScore W1972661330C118552586 @default.
• W1972661330 hasConceptScore W1972661330C126322002 @default.
• W1972661330 hasConceptScore W1972661330C149151106 @default.
• W1972661330 hasConceptScore W1972661330C181389837 @default.
• W1972661330 hasConceptScore W1972661330C185592680 @default.
• W1972661330 hasConceptScore W1972661330C2776412080 @default.
• W1972661330 hasConceptScore W1972661330C2777056448 @default.
• W1972661330 hasConceptScore W1972661330C2777477808 @default.
• W1972661330 hasConceptScore W1972661330C2780057945 @default.
• W1972661330 hasConceptScore W1972661330C71924100 @default.
• W1972661330 hasConceptScore W1972661330C98274493 @default.
• W1972661330 hasIssue "3" @default.
• W1972661330 hasLocation W19726613301 @default.
• W1972661330 hasLocation W19726613302 @default.
• W1972661330 hasOpenAccess W1972661330 @default.
• W1972661330 hasPrimaryLocation W19726613301 @default.
• W1972661330 hasRelatedWork W1970331292 @default.
• W1972661330 hasRelatedWork W1998356222 @default.
• W1972661330 hasRelatedWork W2001333918 @default.
• W1972661330 hasRelatedWork W2030336508 @default.
• W1972661330 hasRelatedWork W2040155790 @default.

• next