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• W1972661569 abstract "The incidence and mortality of prostate cancer (PCa) vary greatly in different geographic regions, for which lifestyle factors, such as dietary fat intake, have been implicated. Human 15-lipoxygenase-1 (h15-LO-1), which metabolizes polyunsaturated fatty acids, is a highly regulated, tissue-specific, lipid-peroxidating enzyme that functions in physiological membrane remodeling and in the pathogenesis of atherosclerosis, inflammation, and carcinogenesis. We have shown that aberrant overexpression of 15-LO-1 occurs in human PCa, particularly high-grade PCa, and in high-grade prostatic intraepithelial neoplasia (HGPIN), and that the murine orthologue is increased in SV40-based genetically engineered mouse (GEM) models of PCa, such as LADY and TRansgenic Adenocarcinoma of Mouse Prostate. To further define the role of 15-LO-1 in prostate carcinogenesis, we established a novel GEM model with targeted overexpression of h15-LO-1 in the prostate [human fifteen lipoxygenase-1 in mouse prostate (FLiMP)]. We used a Cre- mediated and a loxP-mediated recombination strategy to target h15-LO-1 specifically to the prostate of C57BL/6 mice. Wild-type (wt), FLiMP+/-, and FLiMP+/+ mice aged 7 to 21, 24 to 28, and 35 weeks were characterized by histopathology, immunohistochemistry (IHC), and DNA/RNA and enzyme analyses. Compared to wt mice, h15-LO-1 enzyme activity was increased similarly in both homozygous FLiMP+/+ and hemizygous FLiMP+/- prostates. Dorsolateral and ventral prostates of FLiMP mice showed focal and progressive epithelial hyperplasia with nuclear atypia, indicative of the definition of mouse prostatic intraepithelial neoplasia (mPIN) according to the National Cancer Institute. These foci showed increased proliferation by Ki-67 IHC. No progression to invasive PCa was noted up to 35 weeks. By IHC, h15-LO-1 expression was limited to luminal epithelial cells, with increased expression in mPIN foci (similar to human HGPIN). In summary, targeted overexpression of h15-LO-1 (a gene overexpressed in human PCa and HGPIN) to mouse prostate is sufficient to promote epithelial proliferation and mPIN development. These results support 15-LO-1 as having a role in prostate tumor initiation and as an early target for dietary or other prevention strategies. The FLiMP mouse model should also be useful in crosses with other GEM models to further define the combinations of molecular alterations necessary for PCa progression." @default.
• W1972661569 created "2016-06-24" @default.
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• W1972661569 date "2006-06-01" @default.
• W1972661569 modified "2023-10-10" @default.
• W1972661569 title "Conditional Expression of Human 15-Lipoxygenase-1 in Mouse Prostate Induces Prostatic Intraepithelial Neoplasia: The FLiMP Mouse Model" @default.
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• W1972661569 cites W1492551494 @default.
• W1972661569 cites W1502422706 @default.
• W1972661569 cites W1516153085 @default.
• W1972661569 cites W1522682756 @default.
• W1972661569 cites W1559110433 @default.
• W1972661569 cites W1565006713 @default.
• W1972661569 cites W1598990750 @default.
• W1972661569 cites W1601657151 @default.
• W1972661569 cites W1634801112 @default.
• W1972661569 cites W1781630742 @default.
• W1972661569 cites W1964130844 @default.
• W1972661569 cites W1965551017 @default.
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• W1972661569 cites W1969390245 @default.
• W1972661569 cites W1972160020 @default.
• W1972661569 cites W1973820835 @default.
• W1972661569 cites W1985841114 @default.
• W1972661569 cites W1986462334 @default.
• W1972661569 cites W1991560250 @default.
• W1972661569 cites W1994772304 @default.
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• W1972661569 cites W2024842895 @default.
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• W1972661569 cites W2115314035 @default.
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• W1972661569 cites W2130584498 @default.
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• W1972661569 cites W2133383938 @default.
• W1972661569 cites W2136611420 @default.
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• W1972661569 doi "https://doi.org/10.1593/neo.06202" @default.
• W1972661569 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1601466" @default.
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