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- W1972666522 abstract "Pharmacotherapies to lower blood pressure and cholesterol are effective in the primary prevention of cardiovascular disease (CVD). The use of fixed-dose medication combinations has not been well studied. The authors created a Markov model to analyze the cost-effectiveness of 4 fixed-dose medications for primary CVD prevention in men. The initial decision node was to treat or not treat men older than 55 years, without CVD, hypertension, or dyslipidemia with a combination of simvastatin, captopril, hydrochlorothiazide, and atenolol. Probability, costs, and effectiveness were derived from the literature. The outcome variable was marginal cost per quality-adjusted life-year (QALY). Sensitivity analyses were performed. The average cost of treatment was $70,000 compared with $93,000 for non-treatment. Treatment resulted in 13.62 QALYs vs 12.96 QALYs without treatment. Primary prevention of CVD with fixed-dose medications dominated no-treatment. The use of a fixed-dose polypharmacy approach to CVD prevention in men older than 55 years may be cost-effective." @default.
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- W1972666522 date "2008-02-14" @default.
- W1972666522 modified "2023-10-18" @default.
- W1972666522 title "Combination Polypharmacy for Cardiovascular Disease Prevention in Men: A Decision Analysis and Cost-Effectiveness Model" @default.
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- W1972666522 doi "https://doi.org/10.1111/j.1520-037x.2007.06423.x" @default.
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