Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972667727> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W1972667727 abstract "The aim of our study was to evaluate the effects of two different statins and a statin/ezetimibe combination on high sensitive C-reactive protein (hsCRP) values, which were given at high doses in the early period of acute coronary syndromes.A total of 150 patients with non-ST elevation myocardial infarction and unstable angina pectoris were enrolled to our prospective, randomized, single-blind study. Patients were divided into three groups by block randomization method. One group received 20 mg/day atorvastatin, one group received 10 mg/day rosuvastatin and the other group received 10 mg/day ezetimibe/simvastatin combination therapy, which was initiated within the first 24 hours of admission. Follow-up duration was 2 months . Biochemical investigations and hsCRP levels (by nephelometric method) were performed with 138 patients evaluated at baseline, 10th and 60th days of therapy. Decreases of hsCRP levels were analyzed with one-way MANOVA and repeated measures of ANOVA methods. Post-hoc Tukey HSD test was performed for finding the different group, when the difference was detected between the groups.Tenth day hsCRP levels in ezetimibe/simvastatin group was significantly lower than the other groups (p<0.001). Further, after 60 days of follow-up a significant reduction was seen in hsCRP levels in ezetimib/simvastatin group (in ezetimibe/simvastatin group the mean hsCRP was reduced from 38.4±15.0 mg/L to 2.4±1.3 mg/L, in atorvastatin group the mean hsCRP was reduced from 27.3±11.7 mg/L to 4.1±2.4 mg/L and in rosuvastatin group the mean hsCRP was reduced from 22.0±6.9 mg/L to 3.6±1.7 mg/L (F (1.1, 148.2) = 746.9, p<0.01 and the difference between drugs; F (2.2, 148.2) = 32.1, p<0.01). No side effects related to drugs were seen during follow-up in all three treatment groups.This study showed that ezetimibe/simvastatin 10 mg/day combination treatment was superior to atorvastatin 20 mg/day and rosuvastatin 10 mg/day treatment in reducing the inflammatory markers when high dose statins was started in the early period of unstable angina and non ST elevation myocardial infarction." @default.
- W1972667727 created "2016-06-24" @default.
- W1972667727 creator A5000934351 @default.
- W1972667727 creator A5008026621 @default.
- W1972667727 creator A5010753187 @default.
- W1972667727 creator A5031360395 @default.
- W1972667727 creator A5055847200 @default.
- W1972667727 creator A5072544801 @default.
- W1972667727 date "2011-11-01" @default.
- W1972667727 modified "2023-09-26" @default.
- W1972667727 title "Effects of different statins, ezetimibe/simvastatin combination on hsCRP levels in unstable angina pectoris and non-ST elevation myocardial infarction patients: a randomized trial" @default.
- W1972667727 doi "https://doi.org/10.5152/akd.2011.192" @default.
- W1972667727 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22088858" @default.
- W1972667727 hasPublicationYear "2011" @default.
- W1972667727 type Work @default.
- W1972667727 sameAs 1972667727 @default.
- W1972667727 citedByCount "2" @default.
- W1972667727 countsByYear W19726677272016 @default.
- W1972667727 countsByYear W19726677272017 @default.
- W1972667727 crossrefType "journal-article" @default.
- W1972667727 hasAuthorship W1972667727A5000934351 @default.
- W1972667727 hasAuthorship W1972667727A5008026621 @default.
- W1972667727 hasAuthorship W1972667727A5010753187 @default.
- W1972667727 hasAuthorship W1972667727A5031360395 @default.
- W1972667727 hasAuthorship W1972667727A5055847200 @default.
- W1972667727 hasAuthorship W1972667727A5072544801 @default.
- W1972667727 hasBestOaLocation W19726677271 @default.
- W1972667727 hasConcept C102959455 @default.
- W1972667727 hasConcept C105795698 @default.
- W1972667727 hasConcept C126322002 @default.
- W1972667727 hasConcept C164705383 @default.
- W1972667727 hasConcept C168563851 @default.
- W1972667727 hasConcept C204243189 @default.
- W1972667727 hasConcept C2776329913 @default.
- W1972667727 hasConcept C2776839432 @default.
- W1972667727 hasConcept C2776914184 @default.
- W1972667727 hasConcept C2776999253 @default.
- W1972667727 hasConcept C2777482532 @default.
- W1972667727 hasConcept C2777785093 @default.
- W1972667727 hasConcept C2778657065 @default.
- W1972667727 hasConcept C2780499067 @default.
- W1972667727 hasConcept C2781195455 @default.
- W1972667727 hasConcept C33923547 @default.
- W1972667727 hasConcept C500558357 @default.
- W1972667727 hasConcept C71924100 @default.
- W1972667727 hasConcept C90924648 @default.
- W1972667727 hasConceptScore W1972667727C102959455 @default.
- W1972667727 hasConceptScore W1972667727C105795698 @default.
- W1972667727 hasConceptScore W1972667727C126322002 @default.
- W1972667727 hasConceptScore W1972667727C164705383 @default.
- W1972667727 hasConceptScore W1972667727C168563851 @default.
- W1972667727 hasConceptScore W1972667727C204243189 @default.
- W1972667727 hasConceptScore W1972667727C2776329913 @default.
- W1972667727 hasConceptScore W1972667727C2776839432 @default.
- W1972667727 hasConceptScore W1972667727C2776914184 @default.
- W1972667727 hasConceptScore W1972667727C2776999253 @default.
- W1972667727 hasConceptScore W1972667727C2777482532 @default.
- W1972667727 hasConceptScore W1972667727C2777785093 @default.
- W1972667727 hasConceptScore W1972667727C2778657065 @default.
- W1972667727 hasConceptScore W1972667727C2780499067 @default.
- W1972667727 hasConceptScore W1972667727C2781195455 @default.
- W1972667727 hasConceptScore W1972667727C33923547 @default.
- W1972667727 hasConceptScore W1972667727C500558357 @default.
- W1972667727 hasConceptScore W1972667727C71924100 @default.
- W1972667727 hasConceptScore W1972667727C90924648 @default.
- W1972667727 hasLocation W19726677271 @default.
- W1972667727 hasLocation W19726677272 @default.
- W1972667727 hasOpenAccess W1972667727 @default.
- W1972667727 hasPrimaryLocation W19726677271 @default.
- W1972667727 hasRelatedWork W1945607940 @default.
- W1972667727 hasRelatedWork W1972054549 @default.
- W1972667727 hasRelatedWork W1972667727 @default.
- W1972667727 hasRelatedWork W2024710754 @default.
- W1972667727 hasRelatedWork W2132769756 @default.
- W1972667727 hasRelatedWork W2498434420 @default.
- W1972667727 hasRelatedWork W2520240505 @default.
- W1972667727 hasRelatedWork W2606761003 @default.
- W1972667727 hasRelatedWork W2896397587 @default.
- W1972667727 hasRelatedWork W2904558057 @default.
- W1972667727 isParatext "false" @default.
- W1972667727 isRetracted "false" @default.
- W1972667727 magId "1972667727" @default.
- W1972667727 workType "article" @default.