FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972668262> ?p ?o ?g. }

• W1972668262 endingPage "1218" @default.
• W1972668262 startingPage "1195" @default.
• W1972668262 abstract "In squid axons, internally applied ATP potentiates the magnitude of the potassium conductance and slows down its activation kinetics. This effect was characterized using internally dialyzed axons under voltage-clamp conditions. Both amplitude potentiation and kinetic slow-down effects are very selective towards ATP, other nucleotides like GTP and ITP are ineffective in millimolar concentrations. The current potentiation Km for ATP is near 10 microM with no further effects for concentrations greater than 100 microM. ATP effect is most likely produced via a phosphorylative reaction because Mg ion is an obligatory requirement and nonhydrolyzable ATP analogues are without effect. In the presence of ATP, the K current presents more delay, resembling a Cole-Moore effect due to local hyperpolarization of the channel. ATP effect induces a 10-20 mV shift in both activation and inactivation parameters towards more depolarized potentials. As a consequence of this shift, conductance-voltage curves with and without ATP cross at approximately -40 mV. This result is consistent with the hyperpolarization observed with ATP depletion, which is reversed by ATP addition. At potentials around the resting value, addition of ATP removes almost completely K current slow inactivation. It is suggested that a change in the amount of the slow inactivation is responsible for the differences in current amplitude with and without ATP, possibly as a consequence of the additional negative charge carried by the phosphate group. However, a modification of the local potential is not enough to explain completely the differences under the two conditions." @default.
• W1972668262 created "2016-06-24" @default.
• W1972668262 creator A5028939983 @default.
• W1972668262 creator A5074121080 @default.
• W1972668262 creator A5091645168 @default.
• W1972668262 date "1989-06-01" @default.
• W1972668262 modified "2023-09-27" @default.
• W1972668262 title "Modulation of K channels in dialyzed squid axons. ATP-mediated phosphorylation." @default.
• W1972668262 cites W1490696172 @default.
• W1972668262 cites W1984836618 @default.
• W1972668262 cites W1985087389 @default.
• W1972668262 cites W1985770721 @default.
• W1972668262 cites W1985854802 @default.
• W1972668262 cites W1985940938 @default.
• W1972668262 cites W1990076835 @default.
• W1972668262 cites W2000129051 @default.
• W1972668262 cites W2006646833 @default.
• W1972668262 cites W2007399047 @default.
• W1972668262 cites W2010005988 @default.
• W1972668262 cites W2040736033 @default.
• W1972668262 cites W2040811724 @default.
• W1972668262 cites W2043203604 @default.
• W1972668262 cites W2043241280 @default.
• W1972668262 cites W2046414924 @default.
• W1972668262 cites W2051047054 @default.
• W1972668262 cites W2052117744 @default.
• W1972668262 cites W2054707772 @default.
• W1972668262 cites W2054750757 @default.
• W1972668262 cites W2056388241 @default.
• W1972668262 cites W2059542112 @default.
• W1972668262 cites W2059690890 @default.
• W1972668262 cites W2065166902 @default.
• W1972668262 cites W2066082364 @default.
• W1972668262 cites W2071216123 @default.
• W1972668262 cites W2076681662 @default.
• W1972668262 cites W2077196632 @default.
• W1972668262 cites W2078437681 @default.
• W1972668262 cites W2083436541 @default.
• W1972668262 cites W2094590084 @default.
• W1972668262 cites W2119659866 @default.
• W1972668262 cites W2119925335 @default.
• W1972668262 cites W2127849783 @default.
• W1972668262 cites W2136048987 @default.
• W1972668262 cites W2140050141 @default.
• W1972668262 cites W2148824045 @default.
• W1972668262 cites W2154575221 @default.
• W1972668262 cites W2154729040 @default.
• W1972668262 cites W2169198206 @default.
• W1972668262 cites W2171104846 @default.
• W1972668262 cites W2206884908 @default.
• W1972668262 cites W2409870233 @default.
• W1972668262 cites W2418292737 @default.
• W1972668262 doi "https://doi.org/10.1085/jgp.93.6.1195" @default.
• W1972668262 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2216247" @default.
• W1972668262 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2769224" @default.
• W1972668262 hasPublicationYear "1989" @default.
• W1972668262 type Work @default.
• W1972668262 sameAs 1972668262 @default.
• W1972668262 citedByCount "30" @default.
• W1972668262 crossrefType "journal-article" @default.
• W1972668262 hasAuthorship W1972668262A5028939983 @default.
• W1972668262 hasAuthorship W1972668262A5074121080 @default.
• W1972668262 hasAuthorship W1972668262A5091645168 @default.
• W1972668262 hasBestOaLocation W19726682621 @default.
• W1972668262 hasConcept C114614502 @default.
• W1972668262 hasConcept C118716 @default.
• W1972668262 hasConcept C121932024 @default.
• W1972668262 hasConcept C12554922 @default.
• W1972668262 hasConcept C131453863 @default.
• W1972668262 hasConcept C147944092 @default.
• W1972668262 hasConcept C170493617 @default.
• W1972668262 hasConcept C178790620 @default.
• W1972668262 hasConcept C181199279 @default.
• W1972668262 hasConcept C181911157 @default.
• W1972668262 hasConcept C185592680 @default.
• W1972668262 hasConcept C18903297 @default.
• W1972668262 hasConcept C25274449 @default.
• W1972668262 hasConcept C2777743550 @default.
• W1972668262 hasConcept C2778071365 @default.
• W1972668262 hasConcept C2779564974 @default.
• W1972668262 hasConcept C33923547 @default.
• W1972668262 hasConcept C517785266 @default.
• W1972668262 hasConcept C55493867 @default.
• W1972668262 hasConcept C66974803 @default.
• W1972668262 hasConcept C71240020 @default.
• W1972668262 hasConcept C83743174 @default.
• W1972668262 hasConcept C86803240 @default.
• W1972668262 hasConceptScore W1972668262C114614502 @default.
• W1972668262 hasConceptScore W1972668262C118716 @default.
• W1972668262 hasConceptScore W1972668262C121932024 @default.
• W1972668262 hasConceptScore W1972668262C12554922 @default.
• W1972668262 hasConceptScore W1972668262C131453863 @default.
• W1972668262 hasConceptScore W1972668262C147944092 @default.
• W1972668262 hasConceptScore W1972668262C170493617 @default.
• W1972668262 hasConceptScore W1972668262C178790620 @default.
• W1972668262 hasConceptScore W1972668262C181199279 @default.
• W1972668262 hasConceptScore W1972668262C181911157 @default.
• W1972668262 hasConceptScore W1972668262C185592680 @default.

• next