FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972669346> ?p ?o ?g. }

• W1972669346 endingPage "543" @default.
• W1972669346 startingPage "533" @default.
• W1972669346 abstract "Anabolic androgenic steroids are synthetic derivatives of testosterone designed for therapeutic uses, but now taken as drugs of abuse. Potential health risks associated with anabolic androgenic steroid abuse are believed to be higher in adolescents than in adults, but few studies have tested anabolic androgenic steroid effects in adolescent subjects or determined if effects of these steroids differ between females and males. We have studied GABA(A) receptor expression and function in the medial preoptic nucleus of mice chronically treated during adolescence with the anabolic androgenic steroid, 17alpha-methyltestosterone. Three-week treatment did not elicit significant differences the expression of alpha1, alpha2 or alpha5 subunit mRNAs in animals of either sex, although there was a trend toward decreases in all three subunit mRNAs in female mice, which was augmented and attained significance for the alpha2 subunit mRNA in females treated for six weeks. Immunocytochemical analysis revealed that treatment with 17alpha-methyltestosterone for 6 weeks also elicited a significant decrease in the number of alpha2-immunopositive neurons in female subjects. To test if anabolic androgenic steroid treatment also promoted changes in GABA(A) receptor function, spontaneous inhibitory synaptic currents were analyzed in adolescent animals treated for 3-4 weeks. This treatment regimen promoted a significant decrease in spontaneous inhibitory synaptic current frequency in female, but not male mice. Finally, anabolic androgenic steroid treatment was found to have no effect on the numbers of interneurons within the medial preoptic nucleus, as assessed by immunoreactivity for calcium binding proteins, suggesting that the decrease in the frequency of spontaneous inhibitory synaptic currents in female mice does not arise from an anabolic androgenic steroid-induced loss of interneurons. Taken together, our results indicate that chronic exposure to 17alpha-methyltestosterone elicits significant changes in GABAergic transmission in the medial preoptic nucleus of female, but not male, mice effectively enhancing the sexually dimorphic nature of GABAergic transmission in a forebrain region crucial for the expression of aggression and sexual behaviors." @default.
• W1972669346 created "2016-06-24" @default.
• W1972669346 creator A5021672075 @default.
• W1972669346 creator A5030036328 @default.
• W1972669346 creator A5071873861 @default.
• W1972669346 creator A5077648220 @default.
• W1972669346 date "2005-01-01" @default.
• W1972669346 modified "2023-10-16" @default.
• W1972669346 title "Sex-specific effects of chronic anabolic androgenic steroid treatment on GABAA receptor expression and function in adolescent mice" @default.
• W1972669346 cites W1524203275 @default.
• W1972669346 cites W1584834830 @default.
• W1972669346 cites W1789250520 @default.
• W1972669346 cites W1796997407 @default.
• W1972669346 cites W1951315244 @default.
• W1972669346 cites W1965762896 @default.
• W1972669346 cites W1972084420 @default.
• W1972669346 cites W1977663699 @default.
• W1972669346 cites W1981910568 @default.
• W1972669346 cites W1985813433 @default.
• W1972669346 cites W1986657001 @default.
• W1972669346 cites W1990355134 @default.
• W1972669346 cites W1992673078 @default.
• W1972669346 cites W1993836652 @default.
• W1972669346 cites W1998775418 @default.
• W1972669346 cites W2002734921 @default.
• W1972669346 cites W2003550381 @default.
• W1972669346 cites W2006695602 @default.
• W1972669346 cites W2026104991 @default.
• W1972669346 cites W2033702782 @default.
• W1972669346 cites W2039738625 @default.
• W1972669346 cites W2040649843 @default.
• W1972669346 cites W2041413194 @default.
• W1972669346 cites W2041512773 @default.
• W1972669346 cites W2051626926 @default.
• W1972669346 cites W2053533816 @default.
• W1972669346 cites W2054976129 @default.
• W1972669346 cites W2062186332 @default.
• W1972669346 cites W2069808313 @default.
• W1972669346 cites W2086198420 @default.
• W1972669346 cites W2089828703 @default.
• W1972669346 cites W2094078302 @default.
• W1972669346 cites W2096680400 @default.
• W1972669346 cites W2099249565 @default.
• W1972669346 cites W2107277218 @default.
• W1972669346 cites W2108895176 @default.
• W1972669346 cites W2122660499 @default.
• W1972669346 cites W2123247959 @default.
• W1972669346 cites W2125450316 @default.
• W1972669346 cites W2130183336 @default.
• W1972669346 cites W2144727302 @default.
• W1972669346 cites W2146352944 @default.
• W1972669346 cites W2156625231 @default.
• W1972669346 cites W2160958233 @default.
• W1972669346 cites W2170311200 @default.
• W1972669346 cites W2297822668 @default.
• W1972669346 cites W2338465866 @default.
• W1972669346 cites W4239099866 @default.
• W1972669346 cites W4256468807 @default.
• W1972669346 cites W4291712481 @default.
• W1972669346 doi "https://doi.org/10.1016/j.neuroscience.2005.06.041" @default.
• W1972669346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16112473" @default.
• W1972669346 hasPublicationYear "2005" @default.
• W1972669346 type Work @default.
• W1972669346 sameAs 1972669346 @default.
• W1972669346 citedByCount "27" @default.
• W1972669346 countsByYear W19726693462012 @default.
• W1972669346 countsByYear W19726693462013 @default.
• W1972669346 countsByYear W19726693462015 @default.
• W1972669346 countsByYear W19726693462016 @default.
• W1972669346 countsByYear W19726693462021 @default.
• W1972669346 crossrefType "journal-article" @default.
• W1972669346 hasAuthorship W1972669346A5021672075 @default.
• W1972669346 hasAuthorship W1972669346A5030036328 @default.
• W1972669346 hasAuthorship W1972669346A5071873861 @default.
• W1972669346 hasAuthorship W1972669346A5077648220 @default.
• W1972669346 hasConcept C1008401 @default.
• W1972669346 hasConcept C121608353 @default.
• W1972669346 hasConcept C126322002 @default.
• W1972669346 hasConcept C134018914 @default.
• W1972669346 hasConcept C168258287 @default.
• W1972669346 hasConcept C170493617 @default.
• W1972669346 hasConcept C2776166826 @default.
• W1972669346 hasConcept C2777911890 @default.
• W1972669346 hasConcept C2778586440 @default.
• W1972669346 hasConcept C2779279991 @default.
• W1972669346 hasConcept C2779390809 @default.
• W1972669346 hasConcept C2780192828 @default.
• W1972669346 hasConcept C2780902042 @default.
• W1972669346 hasConcept C44796713 @default.
• W1972669346 hasConcept C530470458 @default.
• W1972669346 hasConcept C61367390 @default.
• W1972669346 hasConcept C71315377 @default.
• W1972669346 hasConcept C71924100 @default.
• W1972669346 hasConcept C86803240 @default.
• W1972669346 hasConceptScore W1972669346C1008401 @default.
• W1972669346 hasConceptScore W1972669346C121608353 @default.
• W1972669346 hasConceptScore W1972669346C126322002 @default.
• W1972669346 hasConceptScore W1972669346C134018914 @default.

• next