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• W1972705302 startingPage "1781" @default.
• W1972705302 abstract "The structural similarity between the antileukemic alkaloid coralyne and the carcinogenic and antineoplastic hydrocarbon 7,12-dimethylbenz[a]anthracene, as well as the similarity between the antileukemic alkaloid nitidine and the carcinogenic hydrocarbon 5-methyl-chrysene, prompted a mutagenicity evaluation of coralyne sulfoacetate, nitidine chloride, the 8-ethyl homolog of coralyne, nitidine methosulfate, and the tetramethoxy analog of nitidine by the Ames method against the histidine-auxotroph strains of Salmonella typhimurium TA-1537, TA-1538, TA-98, and TA-100; 7,12-dimethylbenz[a] anthracene was used as a reference standard. The mutagenicity of these antileukemic compounds was either completely eliminated or drastically reduced, but the mutagenic response was generally high for 7,12-dimethylbenz[a]an-thracene. The results suggest that the presence of a quaternary nitrogen atom and alkoxy groups could be important in alleviating the mutagenicity of the parent mutagenic and carcinogenic hydrocarbons." @default.
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• W1972705302 date "1977-12-01" @default.
• W1972705302 modified "2023-10-14" @default.
• W1972705302 title "Absence of Mutagenicity of Coralyne and Related Antileukemic Agents: Structural Comparison with the Potent Carcinogen 7,12-Dimethylbenz[a]anthracene" @default.
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• W1972705302 doi "https://doi.org/10.1002/jps.2600661237" @default.
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