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- W1972719386 endingPage "955" @default.
- W1972719386 startingPage "929" @default.
- W1972719386 abstract "Interleukin-6 (IL-6) is a multifunctional cytokine that plays a central role in host defense due to its wide range of immune and hematopoietic activities and its potent ability to induce the acute phase response. Overexpression of IL-6 has been implicated in the pathology of a number of diseases including multiple myeloma, rheumatoid arthritis, Castleman's disease, psoriasis, and post-menopausal osteoporosis. Hence, selective antagonists of IL-6 action may offer therapeutic benefits. IL-6 is a member of the family of cytokines that includes interleukin-11, leukemia inhibitory factor, oncostatin M, cardiotrophin-1, and ciliary neurotrophic factor. Like the other members of this family, IL-6 induces growth or differentiation via a receptor-system that involves a specific receptor and the use of a shared signaling subunit, gp130. Identification of the regions of IL-6 that are involved in the interactions with the IL-6 receptor, and gp130 is an important first step in the rational manipulation of the effects of this cytokine for therapeutic benefit. In this review, we focus on the sites on IL-6 which interact with its low-affinity specific receptor, the IL-6 receptor, and the high-affinity converter gp130. A tentative model for the IL-6 hexameric receptor ligand complex is presented and discussed with respect to the mechanism of action of the other members of the IL-6 family of cytokines." @default.
- W1972719386 created "2016-06-24" @default.
- W1972719386 creator A5005770280 @default.
- W1972719386 creator A5011373233 @default.
- W1972719386 creator A5025719915 @default.
- W1972719386 creator A5034148285 @default.
- W1972719386 creator A5060396307 @default.
- W1972719386 date "1997-05-01" @default.
- W1972719386 modified "2023-10-12" @default.
- W1972719386 title "Interleukin-6: Structure-function relationships" @default.
- W1972719386 cites W107919769 @default.
- W1972719386 cites W11321320 @default.
- W1972719386 cites W122122989 @default.
- W1972719386 cites W1479791469 @default.
- W1972719386 cites W1483231863 @default.
- W1972719386 cites W1486822318 @default.
- W1972719386 cites W1487898629 @default.
- W1972719386 cites W1488573278 @default.
- W1972719386 cites W1489754199 @default.
- W1972719386 cites W1490191338 @default.
- W1972719386 cites W1491413470 @default.
- W1972719386 cites W1495825435 @default.
- W1972719386 cites W14969070 @default.
- W1972719386 cites W1497311575 @default.
- W1972719386 cites W1499740591 @default.
- W1972719386 cites W1504970855 @default.
- W1972719386 cites W1509482268 @default.
- W1972719386 cites W1510936315 @default.
- W1972719386 cites W1516657748 @default.
- W1972719386 cites W1519760373 @default.
- W1972719386 cites W1537488315 @default.
- W1972719386 cites W1538802759 @default.
- W1972719386 cites W1539584528 @default.
- W1972719386 cites W1546645929 @default.
- W1972719386 cites W1551979974 @default.
- W1972719386 cites W1555431201 @default.
- W1972719386 cites W1556550976 @default.
- W1972719386 cites W1558270545 @default.
- W1972719386 cites W1565454730 @default.
- W1972719386 cites W1566216734 @default.
- W1972719386 cites W1568072008 @default.
- W1972719386 cites W1575122167 @default.
- W1972719386 cites W1576318972 @default.
- W1972719386 cites W1580761697 @default.
- W1972719386 cites W1583209620 @default.
- W1972719386 cites W1594220199 @default.
- W1972719386 cites W1595805439 @default.
- W1972719386 cites W1596383188 @default.
- W1972719386 cites W1597531891 @default.
- W1972719386 cites W1599290645 @default.
- W1972719386 cites W160322612 @default.
- W1972719386 cites W1608821961 @default.
- W1972719386 cites W1621840684 @default.
- W1972719386 cites W1632068222 @default.
- W1972719386 cites W1648936948 @default.
- W1972719386 cites W1650562794 @default.
- W1972719386 cites W1657108383 @default.
- W1972719386 cites W1671275184 @default.
- W1972719386 cites W1740919505 @default.
- W1972719386 cites W1746828832 @default.
- W1972719386 cites W1761563520 @default.
- W1972719386 cites W1776476655 @default.
- W1972719386 cites W1777081626 @default.
- W1972719386 cites W1779773737 @default.
- W1972719386 cites W1836605190 @default.
- W1972719386 cites W1838497045 @default.
- W1972719386 cites W1844501144 @default.
- W1972719386 cites W1903887594 @default.
- W1972719386 cites W1908254726 @default.
- W1972719386 cites W1933007752 @default.
- W1972719386 cites W1937757791 @default.
- W1972719386 cites W1940501985 @default.
- W1972719386 cites W1966212251 @default.
- W1972719386 cites W1966365320 @default.
- W1972719386 cites W1966559114 @default.
- W1972719386 cites W1966796736 @default.
- W1972719386 cites W1967213625 @default.
- W1972719386 cites W1967535509 @default.
- W1972719386 cites W1968814677 @default.
- W1972719386 cites W1969233233 @default.
- W1972719386 cites W1969353460 @default.
- W1972719386 cites W1969408920 @default.
- W1972719386 cites W1971192432 @default.
- W1972719386 cites W1971615288 @default.
- W1972719386 cites W1971623866 @default.
- W1972719386 cites W1971731547 @default.
- W1972719386 cites W1971908211 @default.
- W1972719386 cites W1972155218 @default.
- W1972719386 cites W1973761869 @default.
- W1972719386 cites W1973965625 @default.
- W1972719386 cites W1974019550 @default.
- W1972719386 cites W1974159422 @default.
- W1972719386 cites W1976379940 @default.
- W1972719386 cites W1979114492 @default.
- W1972719386 cites W1979989187 @default.
- W1972719386 cites W1980119013 @default.
- W1972719386 cites W1980143203 @default.
- W1972719386 cites W1980144255 @default.