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- W1972732013 abstract "AbstractAims: There are currently three agents approved by US-FDA for the pharmacotherapy of alcohol dependence, namely Naltrexone, Disulfiram and Acamprosate. The present study aimed to clinically compare Disulfiram (DSF) and Naltrexone (NTX) and their efficacy in relapse prevention in adolescents in a routine clinical setting.Design: Fifty-two adolescents with alcohol dependence with supportive family members that would ensure medical compliance and follow up were randomized to 6 months of treatment with DSF or NTX. Weekly group psycho-education was also provided. The psychiatrist, patient and family member were not blind to the treatment prescribed. Measurements: Alcohol consumption, craving and adverse events were recorded weekly for 4 months and then fortnightly. Serum gamma glutamyl transferase (GGT) was measured at the start and end of the study.Results: At the end of the study, 46 patients were still in contact. Relapse occurred at a mean of 93 days with DSF compared to 63 days for NTX. 84.61% pat..." @default.
- W1972732013 created "2016-06-24" @default.
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- W1972732013 date "2013-07-23" @default.
- W1972732013 modified "2023-09-25" @default.
- W1972732013 title "A comparative study using Disulfiram and Naltrexone in alcohol-dependent adolescents" @default.
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- W1972732013 doi "https://doi.org/10.3109/14659891.2013.813084" @default.
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