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- W1972734534 abstract "In the classical tadpole assay employed for Meyer-Overton type correlations, tricaine and benzocaine are 7–8 times more potent than n-alkanols of equivalent lipid solubility. Median anesthetic concentrations for loss of the righting reflex, AC50(RR)s, were 0.165 and 0.103 mM for tricaine and benzocaine, and log Ps (octanol: water) were 1.81 and 1.98, respectively. Tadpoles receiving a half AC50(RR) each of tricaine and ethanol showed less than additive effects, suggesting a substantial difference in their mechanism(s) of action. AC50(RR)s for both tricaine and benzocaine increased two fold coincident with metamorphosis, reflecting a change from an equilibrium to a nonequilibrium steady state." @default.
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- W1972734534 date "1994-01-01" @default.
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- W1972734534 title "Metamorphosis and the steady state anesthetic concentrations of tricaine, benzocaine and ethanol" @default.
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- W1972734534 doi "https://doi.org/10.1016/1367-8280(94)90015-9" @default.
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