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- W1972788058 startingPage "1410" @default.
- W1972788058 abstract "The phenylacetic acid (PA) transport system of Penicillium chrysogenum is induced by PA, 2-hydroxyphenylacetic and 4-phenylbutyric acids but not by benzoic, phenoxyacetic acid and phenylpropionic acids. Substitution in the aromatic moiety (3-hydroxyphenylacetic, 4-hydroxyphenylacetic acids), replacement of the aromatic moiety by other rings (thiophene-2-acetic acid, indole-3-acetic or indole-3-butyric acids) or the presence of an amino group in the alpha-position (2-aminophenylacetic acid) eliminates inducing activity. 2-Phenylbutyric acid dose not induce the PA transport system indicating that fatty acid-beta-oxidation is needed to generate the authentic regulatory molecule (phenylacetyl-CoA) from 4-phenylbutyric acid. Furthermore, the uptake system synthesized in presence of PA, 2-hydroxyphenylacetic or 4-phenylbutyric acids is under carbon catabolic repression control and is also repressed by L-lysine suggesting that the three molecules induce in P. chrysogenum a single mechanism of transport." @default.
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- W1972788058 date "1989-01-01" @default.
- W1972788058 modified "2023-10-18" @default.
- W1972788058 title "II. Phenylacetic acid transport system in Penicillium chrysogenum Wis 54-1255: Molecular specificity of its induction." @default.
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- W1972788058 doi "https://doi.org/10.7164/antibiotics.42.1410" @default.
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