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- W1972793929 abstract "B lymphopoiesis in senescent mice is typically diminished and characterized by low pre-B cell numbers. The transcription factors E2A, Pax-5, and STAT5 have been implicated in the differentiation, proliferation, and survival of B cell precursors. In this review, we discuss the impairment of B lymphopoiesis during old age in the context of mechanisms at the molecular level responsible for the handling and turnover of these key transcriptional proteins. Alterations in the expression of E2A, Pax-5, and STAT5 may affect multiple stages of B cell development, contribute to reduced B lymphopoiesis, and preface changes in the read-out of the BCR repertoire during murine senescence." @default.
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- W1972793929 date "2005-10-01" @default.
- W1972793929 modified "2023-10-14" @default.
- W1972793929 title "Deficient B lymphopoiesis in murine senescence: potential roles for dysregulation of E2A, Pax-5, and STAT5" @default.
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- W1972793929 doi "https://doi.org/10.1016/j.smim.2005.05.011" @default.
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